Isabelle Fitton
Netherlands Cancer Institute
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Publication
Featured researches published by Isabelle Fitton.
Radiation Oncology | 2010
Coen R. N. Rasch; Roel J.H.M. Steenbakkers; Isabelle Fitton; J. Duppen; Peter J.C.M. Nowak; Frank A. Pameijer; Avraham Eisbruch; Johannes H.A.M. Kaanders; Frank Paulsen; Marcel van Herk
PurposeTo determine the variation in target delineation of nasopharyngeal carcinoma and the impact of measures to minimize this variation.Materials and methodsFor ten nasopharyngeal cancer patients, ten observers each delineated the Clinical Target Volume (CTV) and the CTV elective. After 3D analysis of the delineated volumes, a second delineation was performed. This implied improved delineation instructions, a combined delineation on CT and co-registered MRI, forced use of sagittal reconstructions, and an on-line anatomical atlas.ResultsBoth for the CTV and the CTV elective delineations, the 3D SD decreased from Phase 1 to Phase 2, from 4.4 to 3.3 mm for the CTV and from 5.9 to 4.9 mm for the elective. There was an increase agreement, where the observers intended to delineate the same structure, from 36 to 64 surface % (p = 0.003) for the CTV and from 17 to 59% (p = 0.004) for the elective. The largest variations were at the caudal border of the delineations but these were smaller when an observer utilized the sagittal window. Hence, the use of sagittal side windows was enforced in the second phase and resulted in a decreased standard deviation for this area from 7.7 to 3.3 mm (p = 0.001) for the CTV and 7.9 to 5.6 mm (p = 0.03) for the CTV elective.DiscussionAttempts to decrease the variation need to be tailored to the specific causes of the variation. Use of delineation instructions multimodality imaging, the use of sagittal windows and an on-line atlas result in a higher agreement on the intended target.
International Journal of Radiation Oncology Biology Physics | 2006
R. Steenbakkers; J. Duppen; Isabelle Fitton; Kirsten E.I. Deurloo; Lambert Zijp; Emile F.I. Comans; Apollonia L.J. Uitterhoeve; Patrick Rodrigus; G.W.P.M. Kramer; Johan Bussink; Katrien De Jaeger; J. Belderbos; Peter J.C.M. Nowak; Marcel van Herk; Coen R. N. Rasch
Radiotherapy and Oncology | 2005
R. Steenbakkers; J. Duppen; Isabelle Fitton; Kirsten E.I. Deurloo; Lambert Zijp; Apollonia L.J. Uitterhoeve; Patrick Rodrigus; G.W.P.M. Kramer; Johan Bussink; Katrien De Jaeger; J. Belderbos; Augustinus A. M. Hart; Peter J.C.M. Nowak; Marcel van Herk; Coen R. N. Rasch
International Journal of Radiation Oncology Biology Physics | 2008
Isabelle Fitton; R. Steenbakkers; K. Gilhuijs; J. Duppen; Peter J.C.M. Nowak; Marcel van Herk; Coen R. N. Rasch
International Journal of Radiation Oncology Biology Physics | 2004
R. Steenbakkers; J. Duppen; Anja Betgen; Heidi Lotz; P. Remeijer; Isabelle Fitton; Peter J.C.M. Nowak; Marcel van Herk; Coen R. N. Rasch
International Journal of Radiation Oncology Biology Physics | 2004
R. Steenbakkers; J. Duppen; Isabelle Fitton; Kirsten E.I. Deurloo; Lambert Zijp; A. Eisbruch; Peter J.C.M. Nowak; M. van Herk; C. Rasch
Radiotherapy and Oncology | 2007
Isabelle Fitton; R. Steenbakkers; Lambert Zijp; J. Duppen; Emile F.I. Comans; S.H. Muller; Peter J.C.M. Nowak; Coen R. N. Rasch; Marcel van Herk
Medical Physics | 2011
Isabelle Fitton; Sandra Cornelissen; J. Duppen; Roel J.H.M. Steenbakkers; Stéphanie Peeters; Frank Hoebers; Johannes H.A.M. Kaanders; Peter J.C.M. Nowak; C. Rasch; M. van Herk
International Journal of Radiation Oncology Biology Physics | 2004
R. Steenbakkers; J. Duppen; Isabelle Fitton; Kirsten E.I. Deurloo; Peter J.C.M. Nowak; M. van Herk; C. Rasch
Physica Medica | 2016
Isabelle Fitton; J. Duppen; Roel J.H.M. Steenbakkers; H. Lotz; Peter J.C.M. Nowak; Coen R. N. Rasch; Marcel van Herk