Issahar Ben-Dov
Sheba Medical Center
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Issahar Ben-Dov.
American Journal of Hypertension | 2000
Issahar Ben-Dov; Ehud Grossman; Ayelet Stein; Dov Shachor; Mark Gaides
Obesity and high blood pressure (BP) often coexist. Weight reduction lowers resting BP but its effect on BP during exercise (a predictor of target organ damage) has not been evaluated. Blood pressure was measured at rest and during cycling, before and after weight reduction induced by gastric restriction. Nineteen subjects (4 male), 41 +/-2 (SEM) years of age and body mass index (BMI) of 43 +/- 0.9 kg/m2, were studied. On each occasion BP was measured at rest, at a steady state of 0 and 25 watts, at peak exercise and 1 min into recovery. Body weight was reduced by 28% +/- 6% and BMI decreased from 43.3 +/- 0.9 to 31.5 +/- 0.7 kg/m2 (P < .01). Both BP and heart rate, at rest and at all exercise intensities, were significantly lower after weight reduction. Resting BP decreased from 133 +/-4/87 +/- 3 mm Hg to 115 +/- 4/77 +/- 2 mm Hg (P < .001), and BP at peak exercise decreased from 181 +/- 8/98 +/- 4 to 162 +/- 6/83 +/- 5 mm Hg (P < .001). The change in resting systolic BP did not correlate with the change in body weight or with the change in heart rate, but it correlated with the baseline systolic BP (R = 0.61; P < .005). It is concluded that marked weight reduction reduces BP at rest and at all exercise intensities. Gastroplasty should be considered as an option in morbidly obese hypertensive patients who are not well controlled with conventional treatment, and who fail to lose or to maintain a reduced weight by calorie restriction alone.
Clinical Endocrinology | 2003
Issahar Ben-Dov; Mark Gaides; Mickey Scheinowitz; Rivka Wagner; Zvi Laron
objective Primary IGF‐I deficiency (Laron syndrome, LS) may decrease exercise capacity as a result of a lack of an IGF‐I effect on heart, peripheral muscle or lung structure and/or function.
Respiration | 2007
Tiberiu Shulimzon; Jehudit Rozenman; Marina Perelman; Eytan Bardan; Issahar Ben-Dov
Extraintestinal involvement, including the chest, is common in the late course of Crohn’s disease. We describe 2 female patients in whom the course of the disease was unique in two aspects: (1) each had a pulmonary mass with granulomatous inflammation and necrosis, and (2) these findings had preceded the colonic involvement by 5 years. This sequence supports some of the theories on the pathogenesis of Crohn’s disease and on its possible relation with sarcoidosis, another idiopathic granulomatous disease.
Archives of Physical Medicine and Rehabilitation | 2009
Issahar Ben-Dov; Rachel Zlobinski; Michael J. Segel; Mark Gaides; Tiberiu Shulimzon; G Zeilig
OBJECTIVE To study the effect of posture on the hypercapnic ventilatory responses (HCVR). DESIGN Nonrandomized controlled study. SETTING Rehabilitation hospital and a pulmonary institute. PARTICIPANTS Patients with neurologically stable C(5-8) tetraplegia (n=12) and healthy control subjects (n=7). INTERVENTIONS Not applicable. MAIN OUTCOME MEASURES Supine and seated forced vital capacity (FVC) and HCVR, and supine and erect blood pressure. RESULTS FVC in the sitting position was reduced in patients with tetraplegia (52+/-13% predicted); supine FVC was 21% higher (P=.0005). In the sitting position, HCVR was lower in patients than in controls (0.8+/-0.4 vs 2.46+/-0.3 L/min/mmHg, P<.001). Supine HCVR was not significantly different between the groups. When HCVR was normalized to FVC, there was still a significant difference between patients and controls in the sitting position. Patients with tetraplegia were orthostatic (mean supine blood pressure 91+/-13 mmHg vs mean erect blood pressure 61+/-13 mmHg, respectively, P<.0001). The magnitude of the orthostatism correlated with that of the postural change in HCVR (r=.93, P<.0001). CONCLUSIONS Respiratory muscle weakness may contribute to the attenuated HCVR in tetraplegia. However, the observation that supine HCVR is still low even when normalized to FVC suggests a central posture-dependent effect on the HCVR, which may be linked to the postural effect on arterial blood pressure.
Respiration | 2000
Issahar Ben-Dov; Natacha Chorney; Mark Gaides; Dov Shachor
Background: Thoracic T2–4 sympathectomy (TS) relieves palmar hyperhidrosis. These same roots innervate the heart and the lung. Thoracoscopic TS minimizes damage to the chest wall so that the effect of sympathectomy itself on these organs can be studied. We attempted to determine whether attenuated sympathetic output affects arm or leg exercise tolerance and lung function in young adults who underwent this operation. Methods: Seven subjects, aged 17–30 years, had lung function tests (water spirometer, Godart, Holland), and leg and arm maximal exercise (CPX, MedGraphics, USA), before and 3–6 months after TS. Results: After TS, resting and exercise heart rate and blood pressure were reduced. Baseline leg and arm peak O2 uptake, 2.08 (0.6) and 1.44 (0.5) liters/min, respectively, were not different from the post-TS values, 2.06 (0.7) and 1.54 (0.5) liters/min (nonsignificant). Post-TS lung functions were not significantly reduced. Conclusion: Thoracoscopic T2–4 sympathectomy does not lead to a clinically important fall in lung function and does not compromise arm or leg exercise capacity. Therefore, TS can be done safely in young subjects with palmar hyperhidrosis.
Chest | 2016
Ilaria Campo; Maurizio Luisetti; Matthias Griese; Bruce C. Trapnell; Francesco Bonella; Jan C. Grutters; Koh Nakata; Coline H.M. van Moorsel; Ulrich Costabel; Vincent Cottin; Toshio Ichiwata; Yoshikazu Inoue; Antonio Braschi; Giacomo Bonizzoni; Giorgio Antonio Iotti; Carmine Tinelli; Giuseppe Rodi; Toru Arai; Andrey Bazhanov; Issahar Ben-Dov; Alicia Casey; Deniz Dogru; Wolfgang Gesierich; Maija Halme; Michael Henry; Felix J.F. Herth; Wang Hui-ying; Julia Ilkovich; Sarosh Irani; Vítězslav Kolek
AFFILIATIONS: From the Department of Pulmonary and Critical Care Medicine, Northwestern University. FINANCIAL/NONFINANCIAL DISCLOSURES: See earlier cited article for author conflicts of interest. CORRESPONDENCE TO: Sean B. Smith, MD, Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, 660 N Westmoreland Rd, Lake Forest, IL 60045; e-mail: [email protected] Copyright 2016 Published by Elsevier Inc under license from the American College of Chest Physicians. DOI: http://dx.doi.org/10.1016/j.chest.2016.04.023]
Journal of the American College of Cardiology | 2014
Elad Maor; Yoni Grossman; Ronen Balmor; Michael J. Segel; Paul Fefer; Sagit Ben-Zekry; Yonatan Buber; Elio Di‐Segni; Issahar Ben-Dov; Amit Segev
Heart failure with preserved ejection fraction can lead to pulmonary hypertension. The aim of the current study was to evaluate the diagnostic role of exercise right heart catheterization in the unmasking of diastolic dysfunction. Between 2004 and 2012 164 symptomatic patients with exertional
Respiration | 2007
Issahar Ben-Dov; Ronen Reuveny; Mark Gaides
Background: Uncertainty arises when physiological findings indicate a cardiovascular limitation but the limiting constituents within the cardiovascular system cannot be identified. Objectives: It was the aim of this study to investigate the value of two-modality exercise testing to assess effort intolerance when the cause remains obscure despite standard exercise testing. Methods: A second modality maximal exercise test to fatigue, using either upper extremity or supine exercise, was performed following a nonconclusive standard sitting ergometry. Six patients (4 males) with a mean age of 56 ± 22 years with severe exercise intolerance were enrolled in the study. Results: In 4 of the patients, arm exercise capacity exceeded leg capacity, indicating peripheral limitation. In 1 of these patients, hemoglobin saturation decreased markedly only during sitting exercise while it remained normal during arm exercise, indicating a unique, iatrogenic abnormality. In another patient, supine leg exercise capacity exceeded sitting capacity, indicating peripheral venous limitation, and in an additional patient, leg capacity exceeded arm capacity pointing towards a central abnormality. In all 6 patients, the second modality test highlighted the correct diagnosis. Conclusions: Arm exercise that is added to a standard leg exercise may distinguish between central circulatory and peripheral vascular lower extremity limitation. Supine posture augments venous return to the heart and is useful when preload may be limiting. These modes of exercise may be added to a standard sitting or upright test in order to differentiate between central cardiovascular versus peripheral vascular (arterial or venous) causes of exercise limitation.
Clinical Rheumatology | 2018
Matthew Koslow; Shaye Kivity; Vicktoria Vishnevskia-Dai; Issahar Ben-Dov
Sjogren’s syndrome is associated with chronic cough, but sicca symptoms are missing from cough evaluation guidelines. We evaluated patients with unexplained cough for undiagnosed Sjogren’s syndrome. Patients referred to our pulmonary clinic (Sheba Medical Center, 2009 to 2012) with unexplained cough and concomitant dry eyes were selected for evaluation. Unexplained cough was defined as chronic cough of unknown etiology despite algorithm-based evaluation and treatment. Patients were evaluated in a dedicated clinic by a pulmonologist, rheumatologist, and ophthalmologist specializing in autoimmune disease. Patients completed the Leicester Cough Questionnaire, spirometry, antibody testing for anti Ro/La, ophthalmologic examination with visual acuity, eyelid, ocular surface fluorescein staining, tear break-up time and Schirmer’s test, full slit lamp, and fundus examinations. Four-year follow-up was conducted by telephone questionnaire. We identified 24 patients among which 22 (21 females) agreed for evaluation. Eight patients (36%), seven initially, and one during follow-up were diagnosed with Sjogren’s syndrome (SS) (six secondary and two primary SS). At 4-year follow-up, cough tended to persist and improve in only 37% with SS. These include 2 (Scl and RA) who received rituximab and 1 (stage 1 sarcoidosis) with spontaneous improvement. In contrast, cough improved in most (64%) patients without SS; the majority (eight/nine) report intensified disease-specific treatment (five allergic and three GERD). We describe patients in whom unexplained chronic cough was associated with dry eyes. Focused workup revealed undiagnosed Sjogren’s syndrome in 36%. Dry eyes, with or without SS, is under-recognized and should be added to diagnostic algorithms for unexplained cough.
international conference on virtual rehabilitation | 2015
G Zeilig; H. Weingarden; A. Obuchov; A. Bloch; Mark Gaides; R. Reuveny; Issahar Ben-Dov
Walking on the Lokomat, a motorized robotic gait orthosis (MRGO), was assessed as a method of increasing metabolic activity in individuals with high spinal cord injury. We assessed 11 participants, comparing sessions of robotic walking to passive pedaling, measuring oxygen consumption and carbon dioxide production. The robotic walking did increase the metabolic markers, while the passive pedaling did not.