Issei Ohtsuka
Eisai
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Publication
Featured researches published by Issei Ohtsuka.
Analytical Biochemistry | 1986
Hiromitsu Yokohama; Issei Ohtsuka; Hiroyuki Shiojiri; Kouich Katayama; Seiji Ishikawa
Abstract A high-performance liquid chromatographic method has been developed for the measurement of cholesterol 7α-hydroxylase activity in liver microsomes. 7α-Hydroxycholesterol generated from endogenous choleserol was derivatized with anthroyl 1-carbonitrile, chromatographed on a reversephase column, and detected fluorometrically. The detection limit of 7α-hydroxycholesterol was 1 ng/tube. The cholesterol 7α-hydroxylase activity in rat liver microsomes was assayed by this method, and the effects of some detergents and of the addition of exogenous cholesterol together with detergents on the enzyme activity were investigated. The endogenous 7α- and 7β-hydroxy-cholesterol could be also measured by this method.
Journal of Lipid Research | 2000
Hironobu Hiyoshi; Mamoru Yanagimachi; Masashi Ito; Issei Ohtsuka; Ichiro Yoshida; Takao Saeki; Hiroshi Tanaka
Archive | 1994
Ichirou Yoshida; Hironori Ikuta; Yoshio Fukuda; Yoshihito Eguchi; Makoto Kaino; Katsuya Tagami; Naoki Kobayashi; Kenji Hayashi; Hironobu Hiyoshi; Issei Ohtsuka; Makoto Nakagawa; Shinya Abe; Shigeru Souda
Atherosclerosis | 1994
Hiroshi Tanaka; Issei Ohtsuka; Motoji Kogushi; Teiji Kimura; Tohru Fujimori; Takao Saeki; Kenji Hayashi; Hiroko Kobayashi; Toshie Yamada; Hironobu Hiyoshi; Isao Saito
Archive | 1991
Teiji Kimura; Nobuhisa Watanabe; Yasutaka Takase; Kenji Hayashi; Makoto Matsui; Hironori Ikuta; Youji Yamagishi; Kozo Akasaka; Hiroshi Tanaka; Issei Ohtsuka; Takao Saeki; Motoji Kogushi; Tohru Fujimori; Isao Saito
Archive | 1983
Kouichiro Ueda; Satoru Tanaka; Toshinobu Kunii; Kengo Kagei; Tadashi Sato; Ono Hideki; Issei Ohtsuka; Mayumi Kawase; Toshiharu Ohgoh; Tsuneo Wakabayashi
Atherosclerosis | 1996
Motoji Kogushi; Hiroshi Tanaka; Issei Ohtsuka; Toshie Yamada; Hiroko Kobayashi; Takao Saeki; Masahiro Takada; Hironobu Hiyoshi; Mamoru Yanagimachi; Teiji Kimura; Shinji Yoshitake; Isao Saito
Japanese Journal of Pharmacology | 1995
Motoji Kogushi; Hiroshi Tanaka; Hiroko Kobayashi; Toshie Yamada; Issei Ohtsuka; Teiji Kimura; Isao Saito
Archive | 1992
Katsuya Tagami; Ichiro Yoshida; Naoki Kobayashi; Yoshio Fukuda; Yoshihito Eguchi; Makoto Nakagawa; Hironobu Hiyoshi; Hironori Ikuta; Makoto Kaino; Kenji Hayashi; Issei Ohtsuka; Shinya Abe; Shigeru Souda
Archive | 1987
Kouichiro Ueda; Satoru Tanaka; Toshinobu Kunii; Kengo Kagei; Tadashi Sato; Hideki Ono; Issei Ohtsuka; Mayumi Kawase; Toshiharu Ohgoh; Tsuneo Wakabayashi
