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Dive into the research topics where Iván Sosa is active.

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Featured researches published by Iván Sosa.


Neurosurgery | 2011

Neurological recovery across a 12-cm-long ulnar nerve gap repaired 3.25 years post trauma: case report.

Damien P. Kuffler; Onix Reyes; Iván Sosa; Jose Santiago-Figueroa

BACKGROUND AND IMPORTANCE The standard clinical technique for repairing peripheral nerve gaps is the use of autologous sensory nerve grafts. The present study tested whether a collagen tube filled with autologous platelet-rich fibrin could induce sensory and motor recovery across a 12-cm nerve gap repaired 3.25 years post trauma, and reduce or eliminate neuropathic pain. CLINICAL PRESENTATION Two years postrepair, good ring and small finger motor function had developed that could generate 1 kg of force, and topographically correct 2-point discrimination and sensitivity to vibration in the small and ring finger and proximal but not distal wrist had developed. The patients excruciating neuropathic pain was reduced to tolerable, and he avoided the indicated extremity amputation. The 12-cm-long nerve gap was bridged with a collagen tube filled with autologous platelet-rich fibrin. CONCLUSION We demonstrate that a conduit filled with platelet-rich fibrin can induce limited, but appropriate, sensory and motor recovery across a 12-cm nerve gap repaired 3.25 years post trauma, without sacrificing a sensory nerve, can reduce existing excruciating neuropathic pain to tolerable, and allow avoidance of an indicated upper-extremity amputation. We believe the technique can be improved to induce more extensive and reliable neurological recovery.


Neurosurgery | 1998

Isolation and long-term survival of adult human sensory neurons in vitro.

Iván Sosa; Onix Reyes; Jaime Inserni; Damien P. Kuffler

OBJECTIVE To determine whether adult human dorsal root ganglion neurons can be isolated and maintained in long-term tissue culture, where they would extend processes. METHODS Dorsal root ganglia were removed from adult human organ donors within 2 hours of clamping the aorta. They were then treated with enzymes for one hour, triturated to dissociate the neurons and their satellite cells, and the individual neurons were then plated in tissue culture dishes in medium containing serum. RESULTS Isolated adult human dorsal root ganglion neurons survive in vitro for more than 2 1/2 months, in the absence of exogenously supplied neurotrophins. where they remain electrically excitable and extend processes, CONCLUSIONS Isolated adult human dorsal root ganglion neurons survive in culture for more than 2 1/2 months, extend processes, and remain electrically excitable, without exogenous neurotrophins. These results suggest that, adult human sensory neurons do not require exogenous neurotrophins for survival and process outgrowth, or that sufficient factors were provided by the small number of satellite cells in the cultures. In addition, the neurons survive well in spite of an initial period of up to 14 hours of hypoxia, between the time the aorta was clamped and when the plated neurons were placed in an incubator with the appropriate O2/CO2 environment.


Journal of pediatric rehabilitation medicine | 2011

Fibrotendinous band causing neurogenic Thoracic Outlet Syndrome in adolescent with bilateral cervical ribs

Alexandra Rivera-Vega; Larissa Peguero; Edgar Colon; Fanor M. Saavedra; Iván Sosa; Edwardo Ramos

Thoracic Outlet Syndrome (TOS) describes a variety of symptoms caused by the compression of the neurovascular structures in the cervicoaxillary region as they leave the thorax toward the upper limbs. Causes of TOS are vascular and neurogenic, with neurogenic symptoms being the most common presentation (95% of patients). Symptoms related to neurogenic TOS include intrinsic hand muscle and thenar region atrophy and weakness, as well as medial hand and forearm numbness, which are all suggestive of lower trunk involvement. This condition is very rare in the pediatric population. We are reporting a case of true neurogenic TOS caused by a fibrotendinous band in an adolescent with bilateral cervical ribs who was submitted for surgical treatment at the right side.


Puerto Rico Health Sciences Journal | 2005

Promoting Neurological Recovery following A Traumatic Peripheral Nerve Injury

Onix Reyes; Iván Sosa; Damien P. Kuffler


Journal of Neuroscience Research | 2009

Schwann cell chondroitin sulfate proteoglycan inhibits dorsal root ganglion neuron neurite outgrowth and substrate specificity via a soma and not a growth cone mechanism.

Damien P. Kuffler; Iván Sosa; Onix Reyes


Puerto Rico Health Sciences Journal | 2003

Neuroprotection of spinal neurons against blunt trauma and ischemia.

Onix Reyes; Iván Sosa; Damien P. Kuffler


Puerto Rico Health Sciences Journal | 2007

A novel technique leading to complete sensory and motor recovery across a long peripheral nerve gap.

Onix Reyes; Iván Sosa; José Santiago; Damien P. Kuffler


Puerto Rico Health Sciences Journal | 2011

Vagus Nerve stimulation for intractable seizures in Children: the University of puerto rico experience

Emil A. Pastrana; Samuel Estronza; Iván Sosa


Puerto Rico Health Sciences Journal | 2006

Neuroprotection of Adult Human Neurons Against Ischemia by Hypothermia and Alkalinization

Onix Reyes; Iván Sosa; Damien P. Kuffler


Puerto Rico Health Sciences Journal | 2008

Elimination of a pressure ulcer with electrical stimulation - a case study

Iván Sosa; Onix Reyes; Damien P. Kuffler

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Onix Reyes

University of Puerto Rico

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Juan Vigo

University of Puerto Rico

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Caleb Feliciano

University of Puerto Rico

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Jaime Inserni

University of Puerto Rico

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