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Dive into the research topics where J.A. Shizuru is active.

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Featured researches published by J.A. Shizuru.


Immunological Reviews | 1997

From stem cells to lymphocytes; biology and transplantation

Hector L. Aguila; Koichi Akashi; Jos Domen; Kimberly L. Gandy; Eric Lagasse; Reina E. Mebius; Sean J. Morrison; J.A. Shizuru; Samuel Strober; Nobuko Uchida; Douglas E. Wright; Irving L. Weissman

Summary: We review the development of the hematopoietic system, focusing on the transition from hematopoietic stem cells (HSCs) to T cell This includes the isolation of HSCs, and recent progress in understanding their ontogeny, homing properties, and differentiation. HSC transplantation is reviewed, including the kinetics of reconstitution, engraftment across histocompatibility barriers, the facilitation of allogeneic engraftment, and the mechanisms of graft rejection. We describe progress in understanding T‐cell development in the bone marrow and thymus as well as the establishment of lymph nodes. Finally, the role of bcl‐2 in regulating homeostasis in the hematopoietic system is discussed.


American Journal of Respiratory and Critical Care Medicine | 2010

Strategic Plan for Lung Vascular Research: An NHLBI-ORDR Workshop Report

Serpil C. Erzurum; Sharon Rounds; Troy Stevens; Micheala A. Aldred; Jason M. Aliotta; Stephen L. Archer; Kewal Asosingh; Robert S. Balaban; Natalie N. Bauer; Jahar Bhattacharya; Harm J. Bogaard; Gaurav Choudhary; Gerald W. Dorn; Raed A. Dweik; Karen A. Fagan; Michael B. Fallon; Toren Finkel; Mark W. Geraci; Mark T. Gladwin; Paul M. Hassoun; Marc Humbert; Naftali Kaminski; Steven M. Kawut; Joseph Loscalzo; Donald M. McDonald; Ivan F. McMurtry; John H. Newman; Mark R. Nicolls; Marlene Rabinovitch; J.A. Shizuru

The Division of Lung Diseases of the National Heart, Lung, and Blood Institute, with the Office of Rare Diseases Research, held a workshop to identify priority areas and strategic goals to enhance and accelerate research that will result in improved understanding of the lung vasculature, translational research needs, and ultimately the care of patients with pulmonary vascular diseases. Multidisciplinary experts with diverse experience in laboratory, translational, and clinical studies identified seven priority areas and discussed limitations in our current knowledge, technologies, and approaches. The focus for future research efforts include the following: (1) better characterizing vascular genotype-phenotype relationships and incorporating systems biology approaches when appropriate; (2) advancing our understanding of pulmonary vascular metabolic regulatory signaling in health and disease; (3) expanding our knowledge of the biologic relationships between the lung circulation and circulating elements, systemic vascular function, and right heart function and disease; (4) improving translational research for identifying disease-modifying therapies for the pulmonary hypertensive diseases; (5) establishing an appropriate and effective platform for advancing translational findings into clinical studies testing; and (6) developing the specific technologies and tools that will be enabling for these goals, such as question-guided imaging techniques and lung vascular investigator training programs. Recommendations from this workshop will be used within the Lung Vascular Biology and Disease Extramural Research Program for planning and strategic implementation purposes.


Biology of Blood and Marrow Transplantation | 2007

283: Rituximab infusion two months after total lymphoid irradiation-antithymocyte globulin (TLI-ATG) nonmyeloablative transplantation maintains B-cell disease control with minimal GVHD

Sally Arai; Bita Sahaf; Carol Jones; James L. Zehnder; Robert Lowsky; Samuel Strober; J.A. Shizuru; R. Negrin; Laura J. Johnston; Ginna G. Laport; Keith Goldstein; J. Brown; Linda Elder; Kathryn Tierney; Phillip W. Lavori; David B. Miklos


Biology of Blood and Marrow Transplantation | 2006

Treatment for acute myelogenous leukemia by low dose Total Body Irradiation (TBI) based conditioning and hematopoietic cell transplantation from related and unrelated donors

Georg-Nikolaus Franke; Ute Hegenbart; Dietger Niederwieser; Michael B. Maris; J.A. Shizuru; Monic J. Stuart; Hildegard Greinix; Catherine Cordonnier; Bernard Rio; Alois Gratwohl; Thoralf Lange; W. Poenisch; L. Grommisch; Haifa-Kathrin Al-Ali; Barry E. Storer; David G. Maloney; Effie W. Petersdorf; Peter A. McSweeney; T. Chauncey; Edward Agura; Elliot M. Epner; Richard T. Maziarz; Finn Bo Petersen; Benedetto Bruno; Rainer Storb


Biology of Blood and Marrow Transplantation | 2012

Infusion of Syngeneic Apoptotic Cells Prior to Bone Marrow Transplantation Decreases Tcell Proliferation and Increases Survival

Mareike Florek; Emanuela Sega; A.M.S. Mueller; Dennis B. Leveson-Gower; J.A. Shizuru; Robert S. Negrin


Biology of Blood and Marrow Transplantation | 2012

Space and Tolerance Are Critical for Engraftment of Hematopoietic Allografts in Recipients Conditioned with Total Lymphoid Irradiation Plus ATG

A.M.S. Mueller; Jessica Poyser; Natascha J Kuepper; Cassandra E. Burnett; Holbrook Kohrt; Mareike Florek; Pei Zhang; Rose M. Ko; J.A. Shizuru


Journal of Immunology | 2011

Changes in T cell subsets in 12 patients enrolled in a tolerance induction protocol with combined kidney and hematopoietic cell transplantation

Sussan Dejbakhsh-Jones; Kazuhiro Takahashi; Kent P. Jensen; Stephan Busque; John D. Scandling; J.A. Shizuru; Robert Lowsky; Edgar G. Engleman; Samuel Strober


Biology of Blood and Marrow Transplantation | 2011

Donor CD4 Cells Induce Host Microenvironment Inflammation After Nonmyeloablative Hematopoietic Cell Transplantation Which Suppresses Hematopoiesis and Contributes to Graft Rejection

A.M.S. Mueller; Mareike Florek; Husein Hadeiba; J.A. Shizuru


Biology of Blood and Marrow Transplantation | 2011

The Role of AMD3100 as a Preparative Regimen in Allogeneic Hematopoietic Cell Transplantation

R.M. Ko; K. Logronio; A. Czechowicz; J.A. Shizuru


Biology of Blood and Marrow Transplantation | 2011

Long-Term Follow-Up of Metastatic Breast Cancer Patients Receiving Highly Purified Autologous CD34+Thy-1+ Hematopoietic Stem Cells After High-Dose Chemotherapy

A.M.S. Mueller; Holbrook Kohrt; Ginna G. Laport; Robert S. Negrin; Steven Cha; Irving L. Weissman; J.A. Shizuru

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Barry E. Storer

Fred Hutchinson Cancer Research Center

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David G. Maloney

Fred Hutchinson Cancer Research Center

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Edward Agura

Baylor University Medical Center

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