J. de Pascual Teresa

New natural diterpene acids from Juniperus communis

Abstract Three new diterpene acids have been isolated from the leaves of Juniperus communis and their structures, elucidated by spectroscopic methods, were identified as 7-oxo-13-epi- pimara-8,15-dien-18-oic acid, 7α-hydroxysandaracopimaric acid and (14 S)-14,15-dihydroxylabda- 8(17),13(16)-dien-19-oic acid. Biflavonyls, fatty acids and diterpenoids with known structures were also isolated.

Tetracyclic triterpenes and nerolidol derivatives from Santolina oblongifolia

Abstract Three new dammarane type triterpenes, six polyoxygenated nerolidol derivatives and one tricyclic sesquiterpene, named oblongifolidiol, were isolated from the hexane extract of Santolina oblongifolia. The assigned structures were based on their spectral properties and/or chemical correlations.

A diterpene alcohol from Halimium viscosum

Abstract A hexane extract of Halimium viscosum collected at La Fregeneda (Salamanca, Spain) yielded a new diterpene alcohol, tormesol. Its structure was determined by chemical transformations and NMR spectroscopy with 1 H 1 H (COSY), 13 C 13 C (2D-inadequate) and 1 H 13 C (one bond and long range correlations) two-dimensional experiments.

Acetophenones and terpenoids from Senecio Gallicus

Abstract Six new compounds isolated from the aerial part of Senecio gallicus were: 7,11,15-trimethyl-3-methylene hexadecan-1,2-diol diacetate; 7,11,15-trimethyl-3-methylenehexadecan-1,2-diol; 3,5-bis(3-methyl-2-butenyl)-4-acetoxyacetophenone; 3-(2-hydroxy-3-methyl-3-butenyl)-5-(3-methyl-2-butenyl)4-hydroxacetophenone; 3-(2,3-dihydroxy-3-methyl-butyl)-5-(3-methyl-2-butenyl)-4-hydroxyacetophenone and 1,10-epoxy-8α-hydroxy eremophilenolide.

Ent-isolariciresinol in Reseda suffruticosa

Abstract A new lignan, ent-isolariciresinol, has been isolated from the ethanolic extract of the aerial parts of Reseda suffruticosa together with sitosterol glucoside.

Functionalization at C-12 in labdanic diterpenes: synthesis of the natural diterpenic lactones isolated from Cistus ladaniferus L.

Abstract Oxidative cyclization of Labdanediol (XII) and methyl Labdanolate (Ib) with Pb(OAc)4, and subsequent oxidation with reagents as RuO4, O3, CrO3, or (But)2 CrO4 affords, in excellent yield, the natural diterpenic lactones II, III, VII, VIII, XI and XIII, isolated from Cistus ladaniferus L.

Monoterpene derivatives from the essential oil of Aristolochia longa

Abstract Two new pinane monoterpenes, pin-2-en-8-ol and its acetyl derivative, and also β-caryophyllene, caryophyllene oxide, linalool and bornyl acetate were isolated from the essential oil of the aerial parts of Aristolochia longa. From the volatile fraction of the underground part of the plant only the tricyclic sesquiterpenes calarene, maaliol and 1(10)-aristolen-2-one were isolated.

Saccharinic acid lactone from Astragalus Lusitanicus lam. (−)-2-c-methyl-d-erythrono-1,4-lactone☆☆☆

Abstract (−)-2-C-methyl-D-erythrono-1,4-lactone has been isolated from A. lusitanicus , its structure being established by spectroscopic methods and synthesis. This is the first report of a natural saccharinic acid lactone.

Sesquiterpenic acids from Leucanthemopsis pulverulenta

Abstract From Leucanthemopsis pulverulenta (Compositae) ten new sesquiterpenic acids have been isolated. Their structures and absolute stereochemistry were assigned by spectral and chemical evidence; they are the first carboxylic acid members of the cadinane and munrolane series to be found in a natural source.

A rearranged labdane: salmantic acid from Cistus laurifolius

Abstract Salmantic acid, its methyl ester and its diol, salmantidiol, all of which have a new rearranged ent-labdane skeleton, Δ5(10), and a shift of the C-10 methyl group to C-9 were isolated as minor components from Cistus laurifolius.