J. E. García Sánchez
University of Salamanca
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Featured researches published by J. E. García Sánchez.
Antimicrobial Agents and Chemotherapy | 1991
José Ángel García-Rodríguez; J. E. García Sánchez; I. Trujillano
The in vitro activities of six fluoroquinolones against 43 Brucella spp. were compared by testing three different inocula at two medium pH values. The influence of the test conditions was moderate. The activities of all quinolones were lower at pH 5 and with a high inoculum size. Results indicate the lack of effective bactericidal activity of quinolones against most strains of Brucella spp., particularly B. abortus.
Diagnostic Microbiology and Infectious Disease | 1991
José Ángel García-Rodríguez; J. E. García Sánchez; M. I. García García; E. García Sánchez; J. L. Mufioz Bellido
Abstract The susceptibility of 42 strains of Xanthomonas (Pseudomonas) maltophilia to 37 antibiotics (mainly β-lactams, aminoglycosides, and fluorinated quinolones) was tested. Xanthomonas maltophilia was resistant to most β-lactams, with ceftazidime, moxalactam, and ICI-194008 being the most active ones. Aminoglycosides had a very modest activity, with quinolones showing only moderate activity against this species. Trimethoprim/sufamethoxazole was effective against all strains tested. We also tested the synergy of several β-lactam/β-lactamase inhibitors against X. maltophilia . Only aztreonam/clavulanic acid at 3:1, 1:1 and, mainly, 2:1 combinations had synergistic activity, decreasing the rate of resistance from 92.8% for aztreonam alone to 32.4% for aztreonam-clavulanic acid at 1:1 and 0% for aztreonam-clavulanic acid at 2:1.
Antimicrobial Agents and Chemotherapy | 1991
José Ángel García-Rodríguez; J. E. García Sánchez; J.L. Muñoz Bellido; T Nebreda Mayoral; E. García Sánchez; I. García García
Corynebacterium group D2 (CGD2) is involved in urinary tract infections in patients with underlying predisposing factors. This microorganism is highly resistant to a number of antimicrobial agents. We tested the activities of 79 antimicrobial agents against CGD2. beta-Lactams, aminoglycosides, and macrolides were ineffective. Fluorinated quinolones showed irregular activities, ofloxacin being the most active one. Doxycycline, rifampin, and mainly glycopeptides (vancomycin and teicoplanin) were the most active antibiotics against CGD2.
Antimicrobial Agents and Chemotherapy | 1989
José Ángel García-Rodríguez; J. E. García Sánchez; M. I. García García; E. García Sánchez; J.L. Muñoz Bellido
The in vitro activities of amoxicillin, cefuroxime, ceftetrame, cefetamet, cefixime, tigemonam, erythromycin, roxithromycin, and dirithromycin against 30 clinical isolates of Campylobacter pylori were determined by an agar dilution technique. Roxithromycin and amoxicillin (MICs for 90% of isolates tested, 0.01 and 0.06 micrograms/ml, respectively) were the most active antibiotics tested, but all strains were susceptible to all antimicrobial agents tested.
Antimicrobial Agents and Chemotherapy | 1995
J. A. García-Rodríguez; J. E. García Sánchez; I. Trujillano; E. García Sánchez; M. I. García García; M. J. Fresnadillo
The susceptibilities of 120 clinical isolates of Brucella melitensis and 3 reference strains of the same species to six fluoroquinolones (clinafloxacin, PD 117596, PD 131628, PD 138312, PD 140248, and ciprofloxacin) were examined by agar dilution MIC methodology. Clinafloxacin was the most active compound tested (MIC at which 50% of strains tested were inhibited [MIC50] and MIC90 of 0.06 micrograms/ml). Its level of activity was slightly higher than that of PD 117596 (MIC50 and MIC90 of 0.12 micrograms/ml). PD 131628 and ciprofloxacin were less active than clinafloxacin, with MIC50s ranging from 0.12 to 0.25 micrograms/ml and MIC90s of between 0.25 and 0.5 micrograms/ml for the two compounds. The activity levels of PD 138312 and PD 140248, with MIC50s ranging from 1 to 2 micrograms/ml and MIC90s of 4 to 8 micrograms/ml, were lower than those of the other fluoroquinolones tested.
International Journal of Antimicrobial Agents | 1995
J. A. García-Rodríguez; J.L. Muñoz Bellido; J. E. García Sánchez
Oral cephalosporins had been, for years, a small group of compounds belonging to the first or second-generation cephalosporins, with a limited antimicrobial spectrum. New oral first-generation cephalosporins include cefprozil and loracarbef, similar to cefadroxil and cefaclor, respectively, with activity similar to cefaclor but with pharmacokinetic improvements. Second-generation oral cephalosporins are esters of already available cephalosporins, and third-generation oral cephalosporins include a number of drugs whose activity is similar to available parenteral drugs, showing pharmacokinetic advantages and, some of them, better resistance to hydrolysis mediated by extended wide-spectrum beta-lactamases. They may be a good alternative against mild to moderate ENT infections, UTIs, STDs, lower respiratory tract and skin and soft tissue infections, mainly in the outpatient setting.
European Journal of Epidemiology | 1989
José Ángel García-Rodríguez; J. E. García Sánchez; A. C. Gomez Garcia; J.L. Muñoz Bellido
Pulmonary tuberculosis in Europe has been decreasing over the last decades. This study evaluates the current importance of extrapulmonary tuberculosis and its trend over the last 10 years. In a University Hospital in Spain, 20% of all bacteriologically confirmed tuberculosis cases were extrapulmonary. The most frequent site was the urinary tract (73.5%). Ziehl-Neelsen staining was positive in 50.6% of the cases. Lowenstein-Jensen cultures became positive, on average, after 4.6 ± 1.4 weeks. The proportion of extrapulmonary tuberculosis among the total number of tuberculosis cases has steadily increased trend over the period of observation.
Journal of Chemotherapy | 1991
José Ángel García-Rodríguez; J. E. García Sánchez; J.L. Muñoz Bellido; E. García Sánchez; M. I. García García
The activity of meropenem, a new carbapenem, as well as imipenem, ceftazidime, aztreonam, tobramycin, amikacin and ciprofloxacin against 18 strains of Xanthomonas maltophilia and 23 strains of Pseudomonas aeruginosa resistant to imipenem was tested. All strains of X. maltophilia were resistant to both penems. Ceftazidime, tobramycin and ciprofloxacin were the most active antimicrobial agents against this specie. 17% of imipenem-resistant strains of P. aeruginosa were sensitive to meropenem. Ciprofloxacin, amikacin and aztreonam were the most effective agents against these strains.
Drugs | 1993
José Ángel García-Rodríguez; A. del Cañizo; J. E. García Sánchez; Mª.I. García García; I. Miguel de Martinez; J.L. Muñoz Bellido; E. García Sánchez; A. Asensio Ramos
Oral ciprofloxacin is very active against the microorganisms usually isolated from ear infections, and it has been shown to provide effective therapy for acute ear infections. However, chronic ear infections show lower response rates with oral ciprofloxacin, and some studies have demonstrated the usefulness of local ciprofloxacin in these infections (Esposito et ai. 1990). We studied the efficacy of 2 regimens of local ciprofloxacin in the treatment of ear infections in adults.
Antimicrobial Agents and Chemotherapy | 1990
José Ángel García-Rodríguez; J. E. García Sánchez; J.L. Muñoz Bellido; I. Trujillano
Irloxacin and E-3846 are two new fluorinated quinolones. We evaluated the activities of these antimicrobial agents, ciprofloxacin, ofloxacin, enoxacin, pefloxacin, norfloxacin, and nalidixic acid against 1,161 bacterial strains. Ciprofloxacin was the most active quinolone. Irloxacin did not show great activity. The activity of E-3846 against gram-negative bacteria was similar to those of ofloxacin and pefloxacin, and E-3846 was the most active quinolone against gram-positive bacteria and anaerobes.