J. Proska

Short pulse laser interaction with micro-structured targets: simulations of laser absorption and ion acceleration

The interaction of an ultrashort intense laser pulse with thin foil targets is accompanied by the acceleration of ions from the target surface. To make this ion source suitable for application, it is of particular importance to increase the efficiency of laser energy transformation into accelerated ions and the maximum ion energy. This can be achieved by using a thin foil target with a microscopic structure on the front, laser-irradiated surface. The influence of the microscopic structure on the target surface on the laser target interaction and subsequent ion acceleration is studied here using numerical simulations. The influence of the shape and size of the microstructure, the density profile and the laser pulse incidence angle is also studied. Based on the simulation results, we propose to construct the target for ion acceleration experiments by depositing a monolayer of polystyrene microspheres of a size similar to the laser wavelength on the front surface of a thin foil.

Evidence of resonant surface-wave excitation in the relativistic regime through measurements of proton acceleration from grating targets.

The interaction of laser pulses with thin grating targets, having a periodic groove at the irradiated surface, is experimentally investigated. Ultrahigh contrast (~10(12)) pulses allow us to demonstrate an enhanced laser-target coupling for the first time in the relativistic regime of ultrahigh intensity >10(19) W/cm(2). A maximum increase by a factor of 2.5 of the cutoff energy of protons produced by target normal sheath acceleration is observed with respect to plane targets, around the incidence angle expected for the resonant excitation of surface waves. A significant enhancement is also observed for small angles of incidence, out of resonance.

Interaction of Nerve Agent Antidotes with Cholinergic Systems

The poisoning with organophosphorus compounds represents a life threatening danger especially in the time of terroristic menace. No universal antidote has been developed yet and other therapeutic approaches not related to reactivation of acetylcholinesterase are being investigated. This review describes the main features of the cholinergic system, cholinergic receptors, cholinesterases and their inhibitors. It also focuses on the organophosphorus nerve agents, their properties, effects and a large part describes various possibilities in treatments, mainly traditional oxime therapies based on reactivation of AChE. Furthermore, non-cholinesterase coupled antidotal effects of the oximes are thoroughly discussed. These antidotal effects principally include oxime interactions with muscarinic and nicotinic receptors.

Novel acetylcholinesterase reactivator K112 and its cholinergic properties

The oxime reactivator K112 is a member of the new group of xylene linker-containing AChE reactivators. Its cholinergic properties could be of importance at OP poisoning and are not related to the AChE reactivation that has been studied. It has been found that, despite of reactivating potency, this compound has additional effects. These cholinergic effects include a weak inhibition of AChE (IC(50)=43.8 ± 4.88 μM), inhibition of binding to the porcine muscarinic M2 receptor (IC(50)=4.36 μM) and finally, the inhibition of HACU (68.4 ± 9.9%), a key regulatory step in the synthesis of ACh. The inhibition of the binding of (3H)-HC-3 (64.7 ± 4.7%) and the influence on the membrane fluidity have also been observed. Blocking properties of K112 on the muscarinic receptors have been revealed in the in vitro experiment (rat urinary bladder) and in the in vivo experiment (rat heart BPM) as well. All these cholinergic properties could significantly contribute to the antidotal effect of K112 at the poisoning by the organophosphates.

The effect of oxime reactivators on muscarinic receptors: Functional and binding examinations

The antidotal treatment of organophosphorus poisoning is still a problematic issue since no versatile antidote has been developed yet. In our study, we focused on an interesting property, which does not relate to the reactivation of inhibited acetylcholinesterase (AChE) of some oximes, but refers to their anti-muscarinic effects which may contribute considerably to their treatment efficacy. One standard reactivator (HI-6) and two new compounds (K027 and K203) have been investigated for their antimuscarinic properties. Anti-muscarinic effects were studies by means of an in vitro stimulated atrium preparation (functional test), the [(3)H]-QNB binding assay and G-protein coupled receptor assay (GPCR, beta-Arrestin Assay). Based on the functional data HI-6 demonstrates the highest anti-muscarinic effect. However, only when comparing [(3)H]-QNB binding results and GPCR data, K203 shows a very promising compound with regard to anti-muscarinic potency. The therapeutic impact of these findings has been discussed.

In Situ WetSTEM Observation of Gold Nanorod Self-Assembly Dynamics in a Drying Colloidal Droplet

Direct in situ visualization of nanoparticles in a liquid is an important challenge of modern electron microscopy. The increasing significance of bottom-up methods in nanotechnology requires a direct method to observe nanoparticle interactions in a liquid as the counterpart to the ex situ electron microscopy and indirect scattering and spectroscopy methods. Especially, the self-assembly of anisometric nanoparticles represents a difficult task, and the requirement to trace the route and orientation of an individual nanoparticle is of highest importance. In our approach we utilize scanning transmission electron microscopy under environmental conditions to visualize the mobility and self-assembly of cetyltrimethylammonium bromide (CTAB)-capped gold nanorods (AuNRs) in an aqueous colloidal solution. We directly observed the drying-mediated AuNR self-assembly in situ during rapid evaporation of a colloidal droplet at 4°C and pressure of about 900 Pa. Several types of final AuNR packing were documented including side-by-side oriented chains, tip-to-tip loosely arranged nanorods, and domains of vertically aligned AuNR arrays. The effect of local heating by electron beam is used to qualitatively asses the visco-elastic properties of the formed AuNR/CTAB/water membrane. Local heating induces the dehydration and contraction of a formed membrane indicated either by its rupture and/or by movement of the embedded AuNRs.

Laser ion acceleration: from present to intensities achievable at ELI-Beamlines

Simulation studies of laser-induced ion acceleration are extended from the present intensities up to ~1022 W/cm2 that will be achieved soon at the ELI-Beamlines facility in Prague. Numerical simulations of target normal sheath acceleration (TNSA) enhancement by micro-structures on the front and rear sides of thin foils will be extended to higher laser intensities together with a brief description of target preparation techniques. Computational study of the impact of laser polarization, laser incidence angle, foil thickness and material is presented for PW laser beam of intensity of the order 1022 W/cm2. Acceleration regime that combines TNSA with radiation pressure acceleration (RPA) is identified.

Enhanced electron acceleration via ultra-intense laser interaction with structured targets

The generation of energetic electrons by the interaction of a short laser pulse with solid “grating” targets, having a periodic groove on the irradiated surface, has been investigated in a regime of ultrahigh contrast (1012) and relativistically strong intensity (> 1019W/cm2). A strong enhancement of both the energy and number of electrons emitted from the target, with respect to at targets, has been observed for incidence angles close to the resonant condition for surface wave excitation. In particular we identified bunches of electrons with energies exceeding 10 MeV which are emitted in a direction close to the target surface. The experimental results are well reproduced by a three-dimensional particle-in-cell simulation, which confirms the dominant role of the surface wave in accelerating the electrons. These results are a step forward the development of high field plasmonics for a number of applications.

Enhanced TNSA acceleration with 0.1-1 PW lasers

The enhancement of laser-driven proton acceleration mechanism in TNSA regime has been demonstrated through the use of advanced nanostructured thin foils. The presence of a monolayer of polystyrene nanospheres on the target frontside has drastically enhanced the absorption of the incident laser beam, leading to a consequent increase in the maximum proton beam energy and total laser conversion efficiency. The experimental measurements have been carried out at the 100 TW and 1 PW laser systems available at the APRI-GIST facility. Experimental results and comparison with particle-in-cell numerical simulations are presented and discussed.

Opal-based photonic crystals: modeling and realization

Photonic crystals (PhC) are very interesting periodic material entities with many attractive physical properties. Moreover opaline-based PhC represent very simple way of realization of these PhC. In this contribution, we present our recent studies on both modeling and realization of these opaline based PhC (primarily based on SiO2). Presented opals were prepared by self-assembly method based on the modification of a simple sedimentation technique. This alternation represented the spatial restriction of space region where the opal was constructed. Even more interesting properties, including the presence of the band gap, can be revealed via infiltrated and / or inverse opals. We have chosen photoconductive poly(9-vinylcarbazole) (PVK) as the material for infiltration and final inversion procedure. We have produced highly regular opals and stable inverse opals. Numerical modeling of these opaline structures has been carried out with the use of both MPB (simulations of simple and infiltrated PhC) and Meep tools (simulations of PhC in inverse configuration with the dispersion of PVK taken in account).