J. Smisterova
University of Groningen
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Publication
Featured researches published by J. Smisterova.
European Journal of Organic Chemistry | 2000
Arthur A. P. Meekel; Anno Wagenaar; J. Smisterova; Jessica E. Kroeze; Peter Haadsma; Bouke Bosgraaf; Marc C. A. Stuart; Alain Brisson; Marcel Herman Jozef Ruiters; Dick Hoekstra; Jan B. F. N. Engberts
Pyridinium amphiphiles have found practical use for the delivery of DNA into cells. Starting from 4-methylpyridine, a general synthesis has been devised for the production of pyridinium amphiphiles which allows variation in both the hydrophobic part and in the headgroup area of the compounds. By means of differential scanning microcalorimetry, zeta potential, particle size measurements and cryo electron microscopy, some characteristics of the pyridinium amphiphile/ DNA complexes have been determined.
European Journal of Organic Chemistry | 2002
Astrid Roosjen; J. Smisterova; Cecile Driessen; Joachim T. Anders; Anno Wagenaar; Dick Hoekstra; Ron Hulst; Jan B. F. N. Engberts
Pyridinium amphiphiles have found practical application for the delivery of DNA into eukaryotic cells. A general synthetic method starting from (iso)nicotinoyl chloride has been devised for the preparation of pyridinium amphiphiles based on (bio)degradable esters, allowing structural variation both in the hydrophobic part and in the headgroup area. By means of differential scanning calorimetry, transmission electron microscopy and UV measurements, some characteristics, including hydrolytic behaviour, have been determined. In vitro transfection ability and toxicity have been determined using the eukaryotic COS-7 cell line.
Journal of Biological Chemistry | 2001
J. Smisterova; Anno Wagenaar; Marc C. A. Stuart; Evgeny Polushkin; Gerrit ten Brinke; Ron Hulst; Jan B. F. N. Engberts; Dirk Hoekstra
European Journal of Organic Chemistry | 2003
D Pijper; E Bulten; J Smisterova; Anka Wagenaar; Dick Hoekstra; Jan B. F. N. Engberts; Ron Hulst; J. Smisterova
Journal of the American Chemical Society | 2005
Marco Scarzello; J. Smisterova; Anno Wagenaar; Marc C. A. Stuart; Dick Hoekstra; Jan B. F. N. Engberts; Ron Hulst
European Journal of Organic Chemistry | 2004
Ron Hulst; Inouk Muizebelt; P. Oosting; C. van der Pol; Anno Wagenaar; J. Smisterova; E. Bulten; C. Driessen; Dirk Hoekstra; Jan B. F. N. Engberts
10th Meeting of the NATO-Advanced-Studies-Institute on Targeting of Drugs: Strategies for Gene Constructs and Delivery | 2000
Volker Oberle; Inge S. Zuhorn; Sandrine Audouy; Udo Bakowsky; J. Smisterova; Jan B. F. N. Engberts; Dick Hoekstra
10th Meeting of the NATO-Advanced-Studies-Institute on Targeting of Drugs: Strategies for Gene Constructs and Delivery | 2000
Volker Oberle; Inge S. Zuhorn; Sandrine Audouy; Udo Bakowsky; J. Smisterova; Jan B. F. N. Engberts; Dick Hoekstra
Journal of Controlled Release | 2005
M Haas; Sandrine Audouy; Inouk Muizebelt; J. Smisterova; Jan B. F. N. Engberts; Dick Hoekstra; G Storm; Ron Hulst
229th National Meeting of the American-Chemical-Society | 2005
Marco Scarzello; J. Smisterova; Marc C. A. Stuart; Dirk Hoekstra; Jan B. F. N. Engberts; Ron Hulst
