Ja Leendertz

Radar-Based Breast Cancer Detection Using a Hemispherical Antenna Array—Experimental Results

In this contribution, an ultrawideband (UWB) microwave system for breast cancer detection is presented. The system is based on a novel hemispherical real-aperture antenna array, which is employed in a multi-static radar-based detection system. The array consists of 16 UWB aperture-coupled stacked-patch antennas located on a section of a hemisphere. The radar system is designed to be used with realistic three-dimensional (3D) breast phantoms, which have been developed, as well as with real breast cancer patients during initial clinical trials. Images are formed using two different beamforming algorithms and the performance of these algorithms is firstly compared through numerical simulation. Experimental results for the same beamforming techniques are then presented, demonstrating the successful detection of 4 and 6 mm diameter spherical tumors in the curved breast phantom.

The significance of glucocorticoid pulsatility.

Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species that have been studied. In the rat there is an approximately hourly rhythm of corticosterone secretion, which appears to be regulated by alternating activation and inhibition of the HPA axis. At the level of signal transduction, the response to these pulses of corticosterone is determined by its dynamic interaction with the two transcription factors--the glucocorticoid and mineralocorticoid receptors. While the mineralocorticoid receptor remains activated throughout the ultradian cycle, the glucocorticoid receptor shows a phasic response to each individual pulse of corticosterone. This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor.

Microwave Radar-Based Differential Breast Cancer Imaging: Imaging in Homogeneous Breast Phantoms and Low Contrast Scenarios

This paper presents an improved antenna array for radar-based breast cancer imaging. The improvement was achieved by increasing the number of antennas in the array to 31 elements, as well as by improving the antenna design itself. Using an experimental setup, with homogeneous curved breast phantoms, we have demonstrated substantial imaging improvement with the new antenna array. The new system is also able to detect 7 mm-diameter tumor phantoms in any location within the breast, even as close as 4 mm from the skin layer. Additionally, we have shown good imaging results in low-contrast scenarios, where the dielectric contrast between tumor and normal tissue was reduced to 2:1. Presented results clearly demonstrate the large impact of antennas characteristics on imaging performance.

A Comparison of a Wide-Slot and a Stacked Patch Antenna for the Purpose of Breast Cancer Detection

A wide-slot UWB antenna is presented for intended use in the detection scheme being developed at the University of Bristol, based on the principle of synthetically focused UWB radar using a fully populated static array. The antennas measured and simulated, input and radiation characteristics are presented and compared to an existing, stacked patch antenna that has been designed for the same purpose. The results of this study show that the wide-slot antenna has excellent performance across the required frequency range. Compared to the stacked-patch antenna used in our previous array, the wide-slot antenna can be 3 times smaller (in terms of front surface). The compact nature of the slot antenna means that the detection array can be densely populated. Additionally, this new antenna offers better radiation coverage of the breast. For angles up to 60° away from bore-sight radiated pulses are almost identical (fidelity >95%), whereas for the patch antenna fidelity falls to 58% at the angular extremes. This uniform radiation into the breast should result in focused images with low levels of clutter.

Microwave Radar-Based Breast Cancer Detection: Imaging in Inhomogeneous Breast Phantoms

This letter presents, for the first time, experimental work on microwave breast cancer imaging using inhomogeneous breast phantoms. A recently designed 31-antenna array is used in imaging experiments. The imaging system operates in the full ultrawideband frequency range, between 3 and 10 GHz. To verify imaging performance of our system, new breast phantoms with inhomogeneous interior were developed. For three different breast phantoms presented in this work, the contrast between spherical phantom tumors and surrounding materials ranges from 5:1 to 1.6:1. Our results show that the biggest challenge in radar microwave imaging is the inhomogeneity of the volume being sensed, and not the contrast itself. In addition to experimental results, we also present the new image formation algorithm, which is a modified version of the delay-and-sum (DAS) algorithm. The new algorithm makes use of a new weighting factor, the coherence factor. The new algorithm is effective in reducing clutter, providing better images. For the most demanding imaging example presented herein, the new algorithm improves the peak clutter-to-target energy ratio by 3.1 dB.

Experimental and clinical results of breast cancer detection using UWB microwave radar

This paper presented the clinical results of breast cancer detection using a radar-based UWB microwave system developed at the University of Bristol. Additionally, the system overview and some experimental laboratory results are presented as well. For the clinical result shown in this contribution, we compare images obtained using the standard X-ray mammography and the radar-based microwave system. The developed microwave system has apparently successfully detected the tumor in correct position, as confirmed on the X-ray image, although the compression suffered by the breast during X-ray makes a precise positional determination impossible.

Rapid Glucocorticoid Receptor-Mediated Inhibition of Hypothalamic-Pituitary-Adrenal Ultradian Activity in Healthy Males

A complex dynamic ultradian rhythm underlies the hypothalamic–pituitary–adrenal (HPA) circadian rhythm. We have investigated in normal human male subjects the importance, site of action, and receptor-mediated processes involved in rapid basal corticosteroid feedback and its interaction with corticotrophin releasing hormone (CRH) drive. Pro-opiomelanocortin (POMC), ACTH, and cortisol were measured every 10 min from healthy males during the awakening period or late afternoon using an automated blood sampling system. Mathematical modeling into discrete pulses of activity revealed that intravenous infusion of the synthetic mixed glucocorticoid/mineralocorticoid agonist prednisolone produced rapid inhibition of ACTH and cortisol pulsatility within 30 min in the morning and afternoon. Any pulse that had commenced at the time of injection was unaffected, and subsequent pulsatility was inhibited. Prednisolone also inhibited ACTH and cortisol secretion in response to exogenous CRH stimulation, inferring rapid feedback inhibition at the anterior pituitary. Circulating POMC peptide concentrations were unaffected, suggesting that the rapid corticosteroid inhibitory effect specifically targeted ACTH secretion from pituitary corticotrophs. Prednisolone fast feedback was only reduced by glucocorticoid receptor antagonist pretreatment and not by mineralocorticoid receptor antagonism, suggesting a glucocorticoid receptor-mediated pathway. The intravenous prednisolone suppression test provides a powerful new tool to investigate HPA abnormalities underlying metabolic and psychiatric disease states.

Improved delay-and-sum beamforming algorithm for breast cancer detection

We have evaluated a modified delay-and-sum (DAS) beamforming algorithm for breast cancer detection with a microwave radar-based system. The improved DAS algorithm uses an additional weight factor calculated at each focal point to improve image quality. These weights essentially represent the quality of preprocessing and coherent radar operation. Using a multistatic UWB radar system based on a hemispherical antenna array, we present experimental detection of 7 mm and 10 mm phantom tumours. We show that the new proposed DAS algorithm improves signal-to-clutter ratio in focused images by 2.65 dB for 10 mm tumour, and by 4.4 dB for 7 mm tumour.

Development of an automated blood sampling system for use in humans

Many hormones are released in a pulsatile or burst-like pattern resulting in fluctuating blood levels that can undergo rapid modulation by physiological and pathological signals. To accurately measure these changes in hormone concentration requires frequent blood sampling, often over extended periods as the overall rhythmicity may vary over 24 hours. The aim of this study was to develop a computerized, automated blood sampling system which allows repeated stress-free blood sample collection from humans over an extended period under basal or test conditions. The system incorporates a peristaltic pump, fraction collector and standard infusion pump together with a custom built electronic control unit linked to a personal computer. Disposable tubing prevents cross-contamination between study participants. The computer programme is modifiable to adjust for the number of specimen tubes and volume of blood collected per sampling cycle. Patency of the collecting line is maintained with 0.9% saline, without the need for heparinization. To validate the system, 10-minute samples for cortisol were collected over 24 hours from five healthy volunteers, of whom two had additional concomitant ACTH sampling. Deconvolution analysis revealed an expected number of hormone secretory episodes and a non-pathological degree of orderliness within the data. There was high concordance between ACTH and cortisol secretory events. The ability of the system to allow multiple measurements and of the software program to link with other physiological monitoring equipment provides a powerful tool to study physiologic/pathophysiologic change in relation to blood hormone and other biomarker levels.

Clinical trials of a multistatic UWB radar for breast imaging

This paper presents the development of a 60-element Ultra-WideBand (UWB) radar system for breast cancer detection and its use in clinical trials. The new system operates in the frequency range of 4–8GHz and is an improvement of the teams previous designs both in terms of the number of measurements made (which is increased by a factor of approximately 4) and in terms of acquisition speed. The 60-antenna radar system has undergone an extensive Clinical Trial in the Breast Care Centre at Frenchay Hospital, Bristol. The rapid data acquisition has improved the accuracy of images while also providing a clinical experience that is more convenient and acceptable to patients.