Jae-Won Kim
Chung-Ang University
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Publication
Featured researches published by Jae-Won Kim.
International Journal of Biological Macromolecules | 2017
Eun-Hye Kim; Ga-Dug Han; Jae-Won Kim; Seung-Hyun Noh; Jae-Gwan Lee; Yoshihiro Ito; Tae-Il Son
Chitosan, which has many biocompatible properties, is used widely in medical field like wound healing, drug delivery and so on. Chitosan could be used as a biomaterial to immobilize protein-drug. There are many methods to immobilize protein-drug, but they have some drawbacks such as low efficiency and denaturation of protein. Therefore, photo-immobilization method is suggested to immobilize protein-drug. Photo-immobilization method is simple-reaction and also needs no additional crosslinking reagent. There has been some effort to modify chitosan to have an ability of photo-immobilization. Generally, visible and UV light reactive chitosan derivatives were prepared. Various types of photo-curable chitosan derivatives showed possibility for application to medical field. For example, they showed ability for protein-immobilization and some of them showed wound-healing effect, anti-adhesive effect, or property to interact directly with titanium surface. In this study, we introduce many types of photo-curable chitosan derivative and their possibility of medical application.
International Journal of Biological Macromolecules | 2019
Seung-Hyun Noh; Shin-Woong Kim; Jae-Won Kim; Taehoon Lee; Jae-Woon Nah; Young-Gi Lee; Mi-Kyung Kim; Yoshihiro Ito; Tae-Il Son
This study demonstrated the anti-adhesion and wound healing effect of a visible light curable anti-adhesion agent using an alginate derivative modified with a furfuryl moiety. Visible light-curable furfuryl alginate (F-Alg) was prepared in conjugation with alginate and furfurylamine by an amide coupling reaction, and the conjugated F-Alg was characterized by 1H NMR analysis. The cytotoxicity, cell adhesion, and cell permeability of the F-Alg were evaluated for use in anti-adhesion applications. Drug immobilization and protein release were assessed to verify whether the alginate derivatives and drugs were photo-immobilized. In in vivo anti-adhesion testing, the new anti-adhesion agent prepared in this study acted as a physical protective layer by forming a biofilm on the surgical site. Additionally, along with gradual decomposition of the photo-crosslinked alginate derivative, the immobilized drug was released, and additional effects such as accelerated wound healing are expected. Thus, visible light-curable F-Alg has good application potential as an anti-adhesion agent.
International Journal of Biological Macromolecules | 2018
Eun-Hye Kim; Jae-Won Kim; Ga-Dug Han; Seung-Hyun Noh; Jae-Hee Choi; Changsun Choi; Mi-Kyung Kim; Jae-Woon Nah; Tae-Yeon Kim; Yoshihiro Ito; Tae-Il Son
Recently, many of studies have been attempted to determine how to decrease adhesion. To effectively prevent adhesion, decrease in unnecessary surgical procedures, prevention of contact with other tissue, and drug treatment for inflammation are required. However, current anti-adhesion materials have disadvantages. To solve current problems, we prepared a biocompatible drug-loaded anti-adhesion barrier using a visible-light curable furfuryl gelatin derivative. We used riboflavin as a photo-initiator in the photo-curing process. The biocompatibility of riboflavin was estimated compared with that of Rose Bengal. In addition, the curing ratio was measured to determine whether riboflavin initiated photo-curing. We also evaluated the curing ratio of riboflavin according to the concentration of F-gelatin and the photo-irradiation time. A drug used to decrease inflammation that causes adhesion should not disappear from the surgical site and should also be released consistently. For this, we observed the release profiles of photo-immobilized ibuprofen with different concentrations of F-gelatin. Because an anti-adhesion barrier should protect from bacterial infection we evaluated the protective ability of a barrier formed by F-gelatin. In conclusion, a drug-loaded anti-adhesion barrier was prepared using a visible-light curable furfuryl gelatin derivative, with riboflavin as a photo-initiator. We expect that this drug-loaded anti-adhesion barrier effectively decrease adhesion formation.
Korean Journal of Otorhinolaryngology-head and Neck Surgery | 2005
Jae-Won Kim; Dae-Hyung Kim; Kyung-Tae Kim; Tae-Youn Kim; Kook-Jin Ko; Jeong-Seok Choi; Young-Mo Kim
Journal of Industrial and Engineering Chemistry | 2017
Eun-Hye Kim; Ga-Dug Han; Seung-Hyun Noh; Jae-Won Kim; Jae-Gwan Lee; Yoshihiro Ito; Tae-Il Son
Korean Journal of Otorhinolaryngology-head and Neck Surgery | 2008
Jae-Won Kim; Yoon-Gun Jung; Chang-Hyo Kim; Bo-Mook Kim; Dong-Youl Lee; Yoon-Suk Oh; Young-Mo Kim
Polymer-korea | 2018
Jae-Won Kim; Eun-Hye Kim; Ga-Dug Han; Seung-Hyun Noh; Shin-Woong Kim; Changsun Choi; Jae-Woon Nah; Tae-Yeon Kim; Tae-Il Son
Journal of Chitin and Chitosan | 2017
Jae-Won Kim; Eun-Hye Kim; Ga-Deuk Han; Seung-Hyun Noh; Hyun-Chul Goo; Ju-Young Yun; Jae-Woon Nah; Tae-Il Son
Korean Journal of Otorhinolaryngology-head and Neck Surgery | 2005
Jae-Won Kim; Yong-Sun Jeon; Kook-Jin Ko; Kyeng-Tae Kim; Jung-Suk Choi; Young-Mo Kim
Journal of Industrial and Engineering Chemistry | 2018
Shin-Woong Kim; Jae-Won Kim; Seung-Hyun Noh; Eun-Hye Kim; Yoshihiro Ito; Jae-Woon Nah; Tae-Il Son