James C. Duchamp

Encapsulation of a Radiolabeled Cluster Inside a Fullerene Cage, 177LuxLu(3−x)N@C80: An Interleukin-13-Conjugated Radiolabeled Metallofullerene Platform

In this communication, we describe the successful encapsulation of (177)Lu into the endohedral metallofullerene (177)Lu(x)Lu(3-x)N@C(80) (x = 1-3) starting with (177)LuCl(3) in a modified quartz Kraschmer-Huffman electric generator. We demonstrate that the (177)Lu (beta-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.

An isomer of the endohedral metallofullerene Sc3N@C80 with D5h symmetry

Abstract The discovery of a new isomer of the endohedral metallofullerene Sc3N@C80 is reported. 13C labeled (∼9%) Sc3N@C80 has been synthesized and has been characterized by HPLC, mass spectroscopy and 13C NMR data. The 13C NMR spectrum shows six peaks with a 1:2:2:1:1:1 ratio that are assigned to the D5h isomer. The results of theoretical calculations are also reported for the Ih and D5h isomers of Sc3N@C80.

The Encapsulation of Trimetallic Nitride Clusters in Fullerene Cages

The Kratschmer-Huffman electric-arc generator typically produces endohedral metallofullerenes in low yields with a wide array of different products, but the introduction of nitrogen leads to a new family of encapsulates. A family of endohedral metallofullerenes AnB3−nN@C2n (n=0–3, x=34, 39, and 40) where A and B are Group III and rare-earth metals is formed by a trimetallic nitride template (TNT) process in relatively high yields. The archetypal representative of this new class is the stable endohedral metallofullerene, Sc3N@C80 containing a triscandium nitride cluster encapsulated in an icosahedron (Ih), C80 cage. The Sc3N@C80 is formed in yields even exceeding empty-cage C84. Other prominent scandium TNT members are Sc3N@C68 and Sc3N@C78. The former Sc3N@C68 molecule represents an exception to the well known isolated pentagon rule (IPR). These new molecules were purified by chromatography with corresponding characterization by various spectroscopic approaches. In this paper we focus on the characterizat...

1D and 2D Solid State NMR of Homonuclear Systems using Magic Angle Spinning

Homonuclear two dimensional NMR techniques for liquids are one of the most important developments of the last two decades. However, many of these useful techniques have not been routinely applied to solids. The majority of homonuclear two dimensional NMR experiments depend on the presence of resolvable scalar couplings. In solids the non-commutativity of the dipolar coupling with the chemical shift for pairs of homonuclear spins has been shown to lead to severe broadening of the NMR lineshape even under MAS. In spite of these problems it can be shown that MAS spectra with resolved J couplings can be observed even when the differences in the anisotropic chemical shifts of coupled pairs of spins are the same order of magnitude as their dipolar coupling. To demonstrate that in many cases it is possible to perform two dimensional NMR experiments in the solid state on strongly coupled homonuclear spin systems, several compounds containing coupled pairs of 31P nuclei have been investigated.