James Coull

Diamine catalyzed hemicyanine dye formation from nonfluorescent precursors through DNA programmed chemistry.

A hemicyanine fluorescent dye was generated by a diamine-catalyzed, DNA-templated, aldol-type condensation from nonfluorescent precursors. Studies of reaction rate and yield as a function of catalyst structure indicated the diamine catalyst operates in a concerted mechanism on both reaction components. Our findings expand the scope of reactions that can be performed by DPC and demonstrate that de novo chemical synthesis of labels can be coupled to biological recognition events in a homogeneous format with essentially no background.

An in numero study of glucose-insulin interaction.

A mathematical model has been developed to simulate the glucose-insulin interaction following a glucose load such as occurs in an IVGTT. This model differs from earlier models in that the insulin response to glucose loading is a recurring all or none threshold response. The model has been simulated on a digital computer using the digital analog simulation language CSMP.

Digital Analog Simulation of Pharmacokinetic Models: II. CSMP

IN THE PREVIOUS PAPER OF THIS SERIES WE PRESENTED a computer simulation technique called MIDAS (Modified Integration Digital Analog Simulator). In this paper we present another computer simulation technique, namely CSMP (Continuous Systems Modeling Program). The latter is an IBM System/360 program for the simulation of continuous systems. Like MIDAS, CSMP was developed in order to allow one to solve on a digital computer problems which are typically structured for an analog computer.

Digital Analog Simulation of Pharmacokinetic Models: I. Midas:

mathematical models to describe the absorption, distribution and elimination of drugs. In particular we cite the recent series of ten articles on Pharmacokinetics by Wagner, which appeared in DRUG INTELLIGENCE between February 1968 and September 1969. The present series of two articles is designed to supplement Wagners work by presenting two computer simulation techniques which greatly facilitate the use of mathematical models for extensive study of biological systems.