James H. Boehmler

Independent Risk Factors for Infection in Tissue Expander Breast Reconstruction

Background: Postoperative infection in tissue expander breast reconstruction causes increased morbidity, cost, and suboptimal patient outcomes. To improve outcomes, it is important to preoperatively identify factors that might predispose to infection and minimize them when possible. It is hypothesized that certain patient characteristics are associated with an increased infection rate. Methods: A retrospective, 6-year, single-institution review of patient records was performed from 413 tissue expanders placed in 300 women for postmastectomy breast reconstruction. Infection was defined as any case where antibiotics were given in response to clinical signs of infection. Fourteen potential risk factors were analyzed. A generalized estimation equations approach was used to perform univariable and multivariable analyses. Results: Antibiotics were given to treat clinical infection in 68 of 413 expanders (16.5 percent), with a median time to diagnosis of 6.5 weeks (range, 1 to 52 weeks). Univariable analysis showed significant association with breast size larger than C cup (p < 0.001), previous irradiation (p = 0.007), repeated implant (p = 0.008), and delayed reconstruction (p = 0.04). All variables except delayed reconstruction remained significant (p < 0.002 for all) in a multivariable model. Additional significant covariates in this model included one surgical oncologist (p = 0.003) and contralateral surgery (p = 0.046). Given infection, one surgical oncologist was associated with an increased rate of mastectomy flap necrosis (p = 0.01). Conclusions: Certain patient characteristics are associated with increased infection in tissue expansion breast reconstruction. Understanding how these predispose to infection requires additional study. Patients identified with these characteristics should be educated about these risks and other reconstructive options to optimize the success of their breast reconstruction.

Analysis of Factors Contributing to Severity of Breast Cancer Related Lymphedema

BackgroundUpper extremity lymphedema is a well-described complication of breast cancer treatment. Risk factors for lymphedema development include axillary lymph node dissection (ALND), obesity, increasing age, radiation, and postoperative complications. In this study, we seek to evaluate a cohort of patients who have either self-referred or been referred to the Department of Physical Therapy for lymphedema treatment. Our goal is to evaluate specific risk factors associated with the severity of lymphedema in this patient population. MethodsAll patients who presented to the Wexner Medical Center at the Ohio State University between January 1, 2009, and December 31, 2010, with a chief complaint of upper extremity lymphedema after breast cancer treatment were reviewed retrospectively. Upper extremity lymphedema index (UELI) was used as a severity indicator and patient factors including demographics and breast cancer treatments were evaluated. Univariate and multivariate statistical analyses were performed. ResultsFifty (4.5%) patients presented for upper extremity lymphedema treatment after breast cancer treatment (total of 1106 patients treated surgically for breast cancer). Greater UELIs were found in patients 50 years and older, those with ALND, radiation, chemotherapy, pathologic stage greater than 3, and an International Society of Lymphology lymphedema stage II (P < 0.05). The multivariate model showed age older than 50 years and pathologic stage greater than 3 were significant predictors of higher UELI (P < 0.05). ConclusionsIn this study, we report that in patients who present for lymphedema treatment, increased UELI is significantly related to ALND, radiation therapy, chemotherapy, age, and pathologic stage. An improved understanding of the patient population referred for lymphedema treatment will allow for the identification of patients who may be candidates for therapeutic intervention.

Decreased Narcotic Use With an Implantable Local Anesthetic Catheter After Deep Inferior Epigastric Perforator Flap Breast Reconstruction

This study evaluated narcotic use after deep inferior epigastric perforator flap breast reconstruction when a local anesthetic catheter was used. A retrospective analysis was performed comparing 40 consecutive control patients (no catheter) to 40 consecutive study patients who had received a pain pump catheter. The catheter was left in the abdomen for 72 hours. Using an equianalgesic table, all narcotic doses (oral and intravenous) were converted to intravenous morphine equivalents. Initial average 24-hour morphine requirement for the control group was 42 mg compared with 33 mg for the study group (P = 0.04). Total hospitalization average morphine requirement for the control group was 71 mg compared with 55 mg for the catheter group (P = 0.03). The use of an implantable local anesthetic catheter placed in the abdomen can decrease narcotic use in the postoperative period after deep inferior epigastric perforator flap breast reconstruction.

Outcomes Analysis of the Role of Plastic Surgery in Extremity Sarcoma Treatment

Over the past 5 years we have developed a multidisciplinary service for the treatment of extremity sarcoma. This service includes orthopedic oncology, neurosurgery, medical and radiation oncology, and plastic surgery. Prior to 2007, the role of plastic surgery in this multidisciplinary team was limited. After 2007, plastic surgery at our institution played an increasingly integral role in multidisciplinary care. Based on the development of the plastic surgery service at our institution, we were able to evaluate the role of plastic surgery in the outcomes following extremity reconstruction after sarcoma resection. We hypothesize that plastic surgery involvement would reduce the amputation rate without altering recurrence rates. We found a decrease in lower-extremity amputation of approximately 20% without any significant change in recurrence rates. The incidence of infectious complications requiring IV antibiotics decreased by about 20%. The incidence of skin graft loss decreased by 75%. We do report a significant increase in partial flap necrosis. Overall, plastic surgery is an essential component of the multidisciplinary team in the care of extremity sarcoma.

Repairing esophageal perforations with a transverse cervical musculofascial flap

Objectives/Hypothesis:Although rare, perforations of the esophagus following spinal surgery via an anterior approach are serious life-threatening problems. Complications include abscess formation, mediastinitis, sepsis, and fistula that can carry a mortality rate of 20%–50%. Early diagnosis and treatment are imperative. A common method of repair is isolation and primary repair of the defect in the esophagus, with interpositional muscle coverage. A transverse cervical myofascial artery flap is described here as a potential reconstructive option. Study Design/Methods:Retrospective review was performed on 3 patients who had repair of esophageal perforations following spinal surgery with an anterior approach. Results:In all 3 cases, hardware was found to be eroding through the esophagus. The hardware was removed at the time of repair and flap coverage in 2 patients, and each went on to an oral diet within 10 days without complication, with follow-up exceeding 6 months. A third patient with recurrent erosions could not have the hardware removed and subsequently suffered with another erosion through the muscle flap. A secondary surgery with pectoralis flap coverage was successful but required revision surgeries for flap debulking. No patients had limitation of shoulder movement after flap reconstruction, and all went on to a normal diet without dysphagia. Conclusions:The transverse cervical artery musculofascial flap can be an ideal method for repair of small cervical esophageal perforations, although spinal hardware should be removed if felt to be the etiology of the perforation.

Reconstruction of an external hemipelvectomy defect with a two-stage fillet of leg-free flap.

The defect created by external hemipelvectomy for bone and soft tissue tumor resection is a challenge to reconstruct because of the exposure of bone, neurovascular structures, and peritoneal contents, particularly in the setting of previous radiotherapy. In a nonsalvageable limb with extensive tumor involvement and radiation damage, a free fillet of leg flap can be used to provide the necessary large volume of tissue for reconstruction without donor site morbidity. Because of the lengthy operative time for the hemipelvectomy procedure, the fillet of leg flap may be subject to long ischemia time and a subsequently compromised outcome. A two-stage fillet of leg flap for a hemipelvectomy defect was performed with two goals: to decrease ischemia time and to allow the necessary resuscitation of the patient between operative stages. Stage one was dissection of a lower fillet of leg flap, transfer and anastomosis to the contralateral femoral vessels, and temporary inset in the groin. The patient and flap were observed in the intensive care unit for several days. The patient returned to the operating room 3 days later for staged external hemipelvectomy and inset of the viable fillet of leg flap. Throughout follow-up, the reconstructive results and functional outcome were excellent.

Aesthetic outcomes in women undergoing breast-conserving therapy followed by mastectomy and microsurgical reconstruction

In women with early‐stage breast cancer, breast‐conserving therapy (BCT) provides comparable survival to mastectomy. BCT has the advantage of preserving most of the breast, its skin envelope and the nipple–areola complex. However, deformity may result from the excision of significant amounts of breast tissue, as well as radiation therapy. Several studies have compared patients who underwent BCT to different patients who underwent mastectomy and reconstruction, and found superior aesthetic outcomes in the latter group. Our goal in this study was to compare the aesthetic outcomes in the same women who underwent BCT followed by mastectomy and reconstruction.

Rotationplasty: a final alternative for active adults with infected total knee arthoplasty

T he Van Nes rotationplasty is a procedure involving osteotomy above and below the knee with attachment of the distal tibia, ankle, and foot to the proximal stump of the femur with 1801 of rotation. This essentially makes the ankle the knee joint, the idea being to make the functional outcome of an above knee amputation (AKA) more similar to a below knee amputation (BKA). The main advantages include less work for ambulation, lower incidence of phantom limb pain, and overall better functional outcome. Rotationplasty is a relatively rare procedure that has primarily been performed in the pediatric population for resection of oncologic disease about the knee. Historically, rotationplasty has not been routinely performed in adults because of the potential increased vascular complications (vessels are less compliant) and an opinion that adults have more difficulty compensating for their foot being in a reversed position in terms of muscle control and range of motion. In our review of the literature, we have found one case report from Switzerland in which rotationplasty was performed for an infected total knee in a 62-year-old lowdemand patient. We report the case of a 38-year-old man with an infected total knee that failed multiple surgical attempts to control infection, including two-stage exchange. Based on our search of the literature, this is the first report of a rotationplasty performed in the United States for a total knee infection as a salvage procedure in an otherwise healthy, active adult. The patient provided informed consent for the details of his treatment to be published.