James Hulsizer
AstraZeneca
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Publication
Featured researches published by James Hulsizer.
Bioorganic & Medicinal Chemistry Letters | 2012
John Mccauley; Cathy Dantzman; Megan M. King; Glen Ernst; Xia Wang; Kelly Brush; William E. Palmer; William Frietze; Donald W. Andisik; Valerie Hoesch; Kenneth Doring; James Hulsizer; Khanh Bui; Jay Liu; Thomas J. Hudzik; Steven Wesolowski
A novel series of piperazine derivatives exhibits sub-nanomolar binding and enhanced subtype selectivity as δ-opioid agonists. The synthesis and SAR are described as well as the application of computational models to improve in vitro ADME and safety properties suitable for CNS indications, specifically microsomal clearance, permeability, and hERG channel inhibition.
Journal of Medicinal Chemistry | 1997
Chris Allan Veale; Peter R. Bernstein; Claudia M. Bohnert; Frederick Jeffrey Brown; Craig Bryant; James R. Damewood; Roger Earley; Scott W. Feeney; Philip Duke Edwards; Bruce Gomes; James Hulsizer; Ben J. Kosmider; Robert D. Krell; Gary Moore; Theodora W. Salcedo; Andrew Shaw; David S. Silberstein; Gary Steelman; Mark Morris Stein; Anne M. Strimpler; Roy M. Thomas; Edward P. Vacek; Joseph C. Williams; Donald John Wolanin; Sheila Woolson
Journal of Medicinal Chemistry | 1996
Cyrus John Ohnmacht; Keith Russell; James Roy Empfield; C.A. Frank; Keith Hopkinson Gibson; Daniel Ray Mayhugh; Frances M. Mclaren; Howard S. Shapiro; Frederick Jeffrey Brown; Diane Amy Trainor; Christopher Ceccarelli; Margaret M. Lin; Brian B. Masek; Janet Marie Forst; Robert Joseph Harris; James Hulsizer; Joseph James Lewis; Stuart M. Silverman; Reed W. Smith; Paul James Warwick; Sen T. Kau; Alexa L. Chun; Thomas L. Grant; Burton B. Howe; Jack H. Li; Shephali Trivedi; Tracy J. Halterman; Christopher Yochim; Martin C. Dyroff; M. Kirkland
Tetrahedron Letters | 2010
Jeffrey G. Varnes; G. Scott Lehr; Gary Moore; James Hulsizer; Jeffrey S. Albert
Archive | 2009
Dean G. Brown; James R. Damewood; Phil Edwards; James Hulsizer; James Campbell Muir; M. Edward Pierson; Ashokkumar Bhikkappa Shenvi; Steven Wesolowski; Dan Widzowski; Michael W. Wood
Archive | 1995
John Edward Warawa; Cyrus John Ohnmacht; Diane Amy Trainor; James Hulsizer
Archive | 2011
Dean G. Brown; James R. Damewood; Phil Edwards; James Hulsizer; James Campbell Muir; M. Edward Pierson; Askokkumar Bhikkappa Shenvi; Steven Wesolowski; Dan Widzowski; Michael W. Wood
Archive | 2010
William C Iii Blackwell; James Hulsizer; Jian Wei Liu; Gary Steelman; Rebecca Urbanek; Dan Widzowski; Ye Wu
Archive | 2009
Dean G. Brown; James R. Damewood; Phil Edwards; James Hulsizer; James Campbell Muir; Jr. M. Edward Pierson; Ashokkumar Bhikkappa Shenvi; Steven Wesolowski; Dan Widzowski; Michael W. Wood
Archive | 2009
William Blackwell; James Hulsizer; Jianwei Liu; Gary Steelman; Rebecca Urbanek; Dan Widzowski; Ye Wu
