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Dive into the research topics where James M. Stattel is active.

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Featured researches published by James M. Stattel.


Proceedings of the National Academy of Sciences of the United States of America | 2008

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn

Adam R. Mezo; Kevin McDonnell; Cristina A. Tan Hehir; Susan C. Low; Vito J. Palombella; James M. Stattel; George D. Kamphaus; Cara Fraley; Yixia Zhang; Jennifer A. Dumont; Alan J. Bitonti

The neonatal Fc receptor FcRn provides IgG molecules with their characteristically long half-lives in vivo by protecting them from intracellular catabolism and then returning them to the extracellular space. Other investigators have demonstrated that mice lacking FcRn are protected from induction of various autoimmune diseases, presumably because of the accelerated catabolism of pathogenic IgGs in the animals. Therefore, targeting FcRn with a specific inhibitor may represent a unique approach for the treatment of autoimmune disease or other diseases where the reduction of pathogenic IgG will have a therapeutic benefit. Using phage display peptide libraries, we screened for ligands that bound to human FcRn (hFcRn) and discovered a consensus peptide sequence that binds to hFcRn and inhibits the binding of human IgG (hIgG) in vitro. Chemical optimization of the phage-identified sequences yielded the 26-amino acid peptide dimer SYN1436, which is capable of potent in vitro inhibition of the hIgG–hFcRn interaction. Administration of SYN1436 to mice transgenic for hFcRn induced an increase in the rate of catabolism of hIgG in a dose-dependent manner. Treatment of cynomolgus monkeys with SYN1436 led to a reduction of IgG by up to 80% without reducing serum albumin levels that also binds to FcRn. SYN1436 and related peptides thus represent a previously uncharacterized family of potential therapeutic agents for the treatment of humorally mediated autoimmune and other diseases.


Proceedings of the National Academy of Sciences of the United States of America | 2004

Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway

Alan J. Bitonti; Jennifer A. Dumont; Susan C. Low; Robert T. Peters; Keith Kropp; Vito J. Palombella; James M. Stattel; Yichun Lu; Cristina A. Tan; Jeffrey J. Song; Ana Maria Garcia; Neil E. Simister; Gerburg M. Spiekermann; Wayne I. Lencer; Richard S. Blumberg


Archive | 2004

Immunoglobulin chimeric monomer-dimer hybrids

Robert T. Peters; Adam R. Mezo; Daniel S Rivera; Alan J. Bitonti; James M. Stattel; Susan C. Low


Archive | 2004

Fc chimeric proteins with anti-hiv drugs

Cristina Tan A. Hehir; Adam R. Mezo; Robert T. Peters; James M. Stattel; Vito J. Palombella; Alan R. Bitonti


Archive | 2012

Fc receptor binding proteins

Christopher Tenhoor; Arumugam Muruganandam; Robert Charles Ladner; Clive R. Wood; Alan J. Bitonti; James M. Stattel; Kevin McDonnell; Liming Liu; Jennifer A. Dumont; Aaron K. Sato


Archive | 2004

Inhibition of drug binding to serum albumin

Alan J. Bitonti; Vito J. Palombella; James M. Stattel; Robert T. Peters


Archive | 2009

ANTIBODIES AGAINST FCRN AND USE THEREOF

Christopher Tenhoor; Arumugam Muruganandam; Robert Charles Ladner; Clive R. Wood; Alan J. Bitonti; James M. Stattel; Kevin McDonnell; Liming Liu; Jennifer A. Dumont; Aaron K. Sato


Hepatology | 2003

249 FCRN-mediated pulmonary delivery of interferon alpha FC-fusion protein in non-human primates

Vito J. Palombella; Danielle Boudreau; Ana M. García; Keith Kropp; Susan Low; Yichun Lu; Kelly Morris; Robert T. Peters; James M. Stattel; Jennifer A. Dumont; Alan J. Bitonti


Archive | 2017

ANTIBODY AGAINST FCRN AND USE THEREOF

Christopher Tenhoor; Arumugam Muruganandam; Ladner Robert Charles; Clive R. Wood; Alan J. Bitonti; James M. Stattel; Kevin McDonnell; Liu Limin; Jennifer A. Dumont; Aaron K. Sato


Archive | 2009

Protéines de liaison au récepteur fc

Christopher Tenhoor; Arumugam Muruganandam; Robert Charles Ladner; Clive R. Wood; Alan J. Bitonti; James M. Stattel; Kevin McDonnell; Liming Liu; Jennifer A. Dumont; Aaron K. Sato

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Alan J. Bitonti

Michigan State University

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