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James P. Beck

Wilmington University

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Publication

Featured researches published by James P. Beck.

Bioorganic & Medicinal Chemistry Letters | 1999

Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists.

James P. Beck; Matt A. Curry; Robert J. Chorvat; Larry W. Fitzgerald; Paul J. Gilligan; Robert Zaczek; George L. Trainor

A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants.

Bioorganic & Medicinal Chemistry Letters | 1999

Purin-8-ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

James P. Beck; Argyrios G. Arvanitis; Matt A. Curry; Joseph T. Rescinito; Larry W. Fitzgerald; Paul J. Gilligan; Robert Zaczek; George L. Trainor

A series of purin-8-ones was prepared and discovered to have excellent binding affinity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation. Thus, the highly potent purin-8-ones show promise as a new class of potential anxiolytics and/or antidepressants.

Journal of Medicinal Chemistry | 2003

Human β-Secretase (BACE) and BACE Inhibitors

Varghese John; James P. Beck; Michael J. Bienkowski; Sukanto Sinha; Robert L. Heinrikson

Archive | 2002

N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives

Varghese John; Michel Maillard; Barbara Jagodzinska; James P. Beck; Andrea Gailunas; John Freskos; John Mickelson; Lakshman Samala; Jennifer Sealy; Ruth E. Tenbrink; Lawrence Fang

Archive | 2002

Macrocycles useful in the treatment of alzheimer's disease

Shon R. Pulley; James P. Beck; Ruth E. Tenbrink; Jon S. Jacobs

Journal of Medicinal Chemistry | 1999

Non-Peptide Corticotropin-Releasing Hormone Antagonists: Syntheses and Structure−Activity Relationships of 2-Anilinopyrimidines and -triazines

Argyrios G. Arvanitis; Paul J. Gilligan; Robert J. Chorvat; Robert Scott Cheeseman; Thomas E. Christos; Rajagopal Bakthavatchalam; James P. Beck; Anthony J. Cocuzza; Frank W. Hobbs; Richard Gerald Wilde; Charles R. Arnold; Dennis R. Chidester; Matthew A. Curry; Liqi He; Andrea Hollis; John D. Klaczkiewicz; Paul Krenitsky; Joseph P. Rescinito; Everett Latham Scholfield; Steven Culp; Errol B. De Souza; Lawrence W. Fitzgerald; Dimitri E. Grigoriadis; S. William Tam; Y.Nancy Wong; Shiew-Mei Huang,✗,◊ and; Helen L. Shen

Journal of Medicinal Chemistry | 1999

Synthesis, Corticotropin-Releasing Factor Receptor Binding Affinity, and Pharmacokinetic Properties of Triazolo-, Imidazo-, and Pyrrolopyrimidines and -pyridines

Robert J. Chorvat; Rajagopal Bakthavatchalam; James P. Beck; Paul J. Gilligan; Richard Gerald Wilde; Anthony J. Cocuzza; Frank W. Hobbs; Robert Scott Cheeseman; Matthew A. Curry; Joseph P. Rescinito; Paul Krenitsky; Dennis R. Chidester; Yarem Ja; John D. Klaczkiewicz; Hodge Cn; Aldrich Pe; Wasserman Zr; Fernandez Ch; Zaczek R; Lawrence W. Fitzgerald; Huang Sm; Shen Hl; Wong Yn; Chien Bm; Argyrios G. Arvanitis

Archive | 1998

Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists

Anthony J. Cocuzza; Frank W. Hobbs; James P. Beck; Paul J. Gilligan

Archive | 1999

THIAZOLO 4,5-d]PYRIMIDINES AND PYRIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS

James P. Beck

Archive | 1998

NITROGEN SUBSTITUTED IMIDAZO 4,5-c]PYRAZOLES AS CORTICOTROPIN RELEASING HORMONE ANTAGONISTS

James P. Beck; Paul J. Gilligan

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Ruth E. Tenbrink

Upjohn

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Shon R. Pulley

Upjohn

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Varghese John

Eli Lilly and Company

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Andrea Gailunas

Upjohn

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Barbara Jagodzinska

Buck Institute for Research on Aging

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Mark A. Smith

DuPont

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Michel Maillard

Institut de Chimie des Substances Naturelles

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Anthony J. Cocuzza

DuPont

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Frank W. Hobbs

DuPont

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John Mickelson

Upjohn

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