Jan Eirik Ellingsen

Bio-Implant Interface : Improving Biomaterials and Tissue Reactions

The progression of dentistry beyond restorative care to include regenerative therapy has been promoted by successes involving tooth root replacement using endosseous dental implants. This success of commercially pure (c.p.) titanium endosseous implants in support of dental prostheses is now well documented. There is growing consensus that uncoated, threaded c.p. titanium implants can provide survival rates greater than 95% when used to support anterior single tooth restorations1 or mandibular prostheses supported by four to five parasymphyseal implants.2 Clinical successes notwithstanding, we confront the absence of significant data to guide future efforts to apply endosseous implant use in the more challenging environments of low density bone and high stress situations such as single implant replacements for molar teeth.SUCCESS AND FAILURE FOR BONE-IMPLANT ATTACHMENTS: AN EVIDENCE-BASED APPROACH The Role of Implant Surface Properties on the Clinical Outcome of Osseointegrated Oral Implant Therapy, M. Esposito, H.V. Worhington, P. Coulthard, A. Wennerberg, P. Thomsen CAN THE IMPLANT MACRO DESIGN AND MICRO TEXTURING IMPROVE BONE RESPONSE? Toward an Optimized Dental Implant Design, S. Hansson Implant Surface Design for Development and Maintenance of Osseointegration, R. Pilliar Bone Response to Surface Roughness Measurement and Results, Experiment and Clinical Studies, A. Wennerberg, T. Albrektsson From Microroughness to Resorbable Bioactive Coatings, S. Szmukler-Moncler, P. Zeggel, D. Perrin, J-P Bernard, H-G Neumann CELL AND TISSUE REACTIONS TO BIOMATERIALS Improving the Bio-Implant Interface by Controlling Cell Behavior Using Surface Topography, D. Brunette, A. Khakbaznejad, M. Takekawa, M. Shimonishi, H. Murakami, M. Wieland, B. Chehroudi, J. Glass-Brudzinski, M. Textor Osteoblast Response to Pure Titanium and Titanium Alloy, M. Paine, J.C. Wong Biomedical Implant Surface Topography and its Effects on Osteoblast Differentiation in vitro, C. Stanford, G. Schneider, H. Perinpanayagam, J.C. Keller, R. Midura Cellular Interactions at Commercially Pure Titanium Implants, L.F. Cooper A Selection of Oral Implant Materials Based on Experimental Studies, P. Thomsen, C.B. Johansson Possibilities to Improving Implants and Regenerating Dentoalveolar Tissues by Tissue Engineering Using Stem Cells and Growth Factors, I. Thesleff, M. Tummers Critical Issues in Endosseous Peri-Implant Wound Healing, J.E. Davies, J.Y. Park THE EXTRACELLULAR MATRIX BIOLOGY AND BIOMINERALIZATION IN BONE FORMATION AND IMPLANT INTEGRATION Initiation and Modulation of Crystal Growth in the Skeletal Tissues: Role of the Extracellular Matrix, C. Robinson, R.C. Shore, S.R. Wood, S.J. Brookes, D. Alistair Smith, J. Kirkham Use of a Matrix Scaffold for Tissue Engineering and Bone Regeneration, M. Bartold, Y. Xiao Inducing Bone Growth Using Extracellular Matrix Proteins, S.P. Lyngstadaas, J.E. Ellingsen, A. Spahr, I. Slaby SURFACE CHEMISTRY, BIOCHEMISTRY, AND MOLECULES: HOW DO THEY INTERACT WITH BIOLOGICAL ENVIRONMENT? How Surfaces Interact with the Biological Environment, P. Tengvall Osteocapacities of Calcium Phosphate Ceramics, J. Jansen, P.J. Rugge, E. van der Wal, A.M. Vredenberg, J.G.C. Wolke Increasing Biocompatibility by Chemical Modification of Titanium Surfaces, J.E. Ellingsen, S.P. Lyngstadaas Use of Molecular Assembly Techniques for Tailoring Chemical Properties of Smooth and Rough Titanium Surfaces, M. Textor, S. Tosatti, M Wieland, D.M. Brunette DEVELOPMENT AND APPLICATION OF SCIENTIFIC DATA: REGULATORY AND COMMERCIAL ASPECTS Development and Application of Scientific Data: Do Industry and Academia Have Different Scientific Perspectives? B. Delin Medical Devices--Regulatory Perspectives and Aspects of Regulatory Risk Management, S. Gestrelius, A. Hensten-Pettersen INVENTIVE FORWARD LOOKS-WHERE DO WE GO FROM HERE? Self-Assembling and Bimimetic Biomaterials, S. Stupp, E. Beniash, J.D. Hartgerink, E.D. Sone The Inert-Bioactivity Conundrum, D.F. Williams Enhancing the Process of Discovery and Innovation for Optimal Host Response at the Implant Surfaces, M.L. Snead