Jan Skouv
University of Copenhagen
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Publication
Featured researches published by Jan Skouv.
Nucleosides, Nucleotides & Nucleic Acids | 1999
Jesper Wengel; Alexei A. Koshkin; Sanjay K. Singh; Poul Nielsen; Michael Meldgaard; Vivek K. Rajwanshi; Ravindra Kumar; Jan Skouv; Christina B. Nielsen; Jens Peter Jacobsen; Nana Jacobsen; Carl Erik Olsen
Abstract LNA (Locked Nucleic Acid) forms duplexes with complementary DNA, RNA or LNA with unprecedented thermal affinities. CD spectra show that duplexes involving fully modified LNA (especially LNA:RNA) structurally resemble an A-form RNA:RNA duplex. NMR examination of an LNA:DNA duplex confirm the 3′-endo conformation of an LNA monomer. Recognition of double-stranded DNA is demonstrated suggesting strand invasion by LNA. Lipofectin-mediated efficient delivery of LNA into living human breast cancer cells has been accomplished.
Proceedings of the National Academy of Sciences of the United States of America | 2000
Claes Wahlestedt; Peter Salmi; Liam Good; Johanna Kela; Thomas Johnsson; Tomas Hökfelt; Christian Broberger; Frank Porreca; Josephine Lai; Kunkun Ren; Michael H. Ossipov; Alexei A. Koshkin; Nana Jakobsen; Jan Skouv; Henrik Oerum; Mogens Havsteen Jacobsen; Jesper Wengel
Archive | 2000
Jan Skouv; Mogens Fenger; Mogens Havsteen Jacobsen
Nucleic Acids Research | 2002
Nana Jacobsen; Joan Bentzen; Michael Meldgaard; Mogens Havsteen Jakobsen; Mogens Fenger; Sakari Kauppinen; Jan Skouv
Archive | 2000
Henrik Ørum; Troels Koch; Jan Skouv; Mogens Havsteen Jakobsen
Clinical Chemistry | 2002
Nana Jacobsen; Mogens Fenger; Joan Bentzen; Søren Lind Rasmussen; Mogens Havsteen Jakobsen; Jef Fenstholt; Jan Skouv
Archive | 2002
Nana Jacobsen; Mogens Havsteen Jakobsen; Jan Skouv
Archive | 2002
Nana Jacobsen; Mogens Havsteen Jakobsen; Jan Skouv
Archive | 2002
Nana Jacobsen; Mogens Havsteen Jakobsen; Jan Skouv
Archive | 2000
Henrik Ørum; Troels Koch; Jan Skouv; Mogens Havsteen Jakobsen
