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Featured researches published by Troels Koch.


Archive | 2008

Chapter 5:Locked Nucleic Acid: Properties and Therapeutic Aspects

Troels Koch; Christoph Rosenbohm; Henrik Frydenlund Hansen; Bo Hansen; Ellen Marie Straarup; Sakari Kauppinen

In 1978 Zamecnik and Stephenson1 showed for the first time that messenger RNA (mRNA) repression could be achieved by single-stranded oligonucleotides (ONs). This mechanistic approach for gene inhibition was later called the antisense (AS) principle. The simplicity of this new principle captivated ma...


Archive | 1989

Photolabeling Reagent Design

Ole Buchardt; Ulla Henriksen; Troels Koch; Peter E. Nielsen

Photolabeling reagents are composed of some or all of the following ligands: Photoprobes, thermal probes, labels, linkers, and cleavable sites. The design and function of such ligands are discussed on the basis of our own attempts to design and test novel ligands and reagents. Novel ligands include diazocyclopentadienylcarbonyloxy photoprobes, biotinyl labels and selenium containing linkers which can be cleaved by very mild oxidation.


Journal of Peptide Science | 1995

Solid-phase synthesis of peptide nucleic acids.

Leif Christensen; Richard Fitzpatrick; Brian D. Gildea; Kenneth H. Petersen; Henrik Hansen; Troels Koch; Michael Egholm; Ole Buchardt; Peter E. Nielsen; James M. Coull; Rolf H. Berg


BioTechniques | 1995

Sequence-specific purification of nucleic acids by PNA-controlled hybrid selection.

Henrik Ørum; Peter E. Nielsen; Jørgensen M; Larsson C; Christopher John Stanley; Troels Koch


Archive | 2002

Therapeutic uses of LNA-modified oligonucleotides in infectious diseases

Margit Wissenbach; Troels Koch; Henrik Ørum; Bo Hansen


Archive | 2000

Therapeutic uses of lna-modified oligonucleotides

Henrik Ørum; Troels Koch; Jan Skouv; Mogens Havsteen Jakobsen


Archive | 1997

Method of analysis using signal amplification

Henrik .O slashed.rum; Troels Koch; Martin Borre; Henrik Frydenlund Hansen


Archive | 1998

2- or 3-dimensional geometric structures

Hans-Georg Dr Rer Nat Batz; Troels Koch; Henrik Frydenlund Hansen


Archive | 2002

Synthesis of allofuranose

Troels Koch; Henrik Frydenlund Hansen


Archive | 2015

Oligonucléotides de type gapmères de lna comprenant des liaisons phosphorothioate chirales

Nanna Albæk; Henrik Frydenlund Hansen; Troels Koch; Christoph Rosenbohm; Peter Hagedorn; Sabine Sewing; Annie Moisan

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