Jane Swanson

Third Example of a Human “D‐like” Antibody or Anti‐LW

The third example of human “D‐like” (LW) antibody is reported. The serum from an rr (cde) patient (VW) agglutinates D positive cells strongly but D negative cells to a lesser degree. The antibody does not react with the patients own cells or with those of her R1r (CDe/cde) sister. When VWs serum is absorbed by ordinary rr (cde) cells, the antibody is removed for D positive and D negative cells and the eluate from the cells contains “D‐like” (LW) antibody. When VWs (“anti‐D‐like”) serum is absorbed by “D‐like” (LW) negative cells, antibody for D positive and D negative cells is not removed and the eluate from these cells contains no antibody.

A New Public Antigenic Determinant Gya (Gregory)

An antibody found in the sera of two sisters defines a new public antigenic determinant Gya (Gregory). The Gy(a—) individuals are the product of a consanguinous mating and are presumably homozygous for a rare gene, Gy, inherited from a common ancestor. Anti‐Gya is an IgG antibody that was stimulated by pregnancy.

Studies on the Distribution of the Blood Group Antigen Doa (Dombrock) and the Characteristics of Anti‐Doa

An antibody developing in Mrs. Dombrock following transfusion, defines a new blood group system. The antigen Doa, present in 64 per cent of Caucasians, has a lower frequency in Indians and Negroes. The immune characteristics of this antibody have been demonstrated by reactions in vitro and in vivo. It is to be expected that if Dombrock proves to be a two allele system, the antigen Dob will occur in 84 per cent of Caucasians.

Mta, A “New” Antigen in the MNSs System

1 An antibody has been found which identifies a “new” antigen belonging to the MNSs system. 2 The “new” blood antigen is inherited as a dominant character and is probably of rare occurrence. 3 The notation Mta is proposed for the “new” blood antigen for Martin, the name of the family in which it was found. 4 The chromosome responsible for the Mta antigen in this family also produces both antigens N and s. 5 The exact place of Mta in the MNSs system is not demonstrable with these data from a single family.