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Dive into the research topics where Janne Mannila is active.

Publication


Featured researches published by Janne Mannila.


International Journal of Pharmaceutics | 2009

Cyclodextrins and chitosan derivatives in sublingual delivery of low solubility peptides: A study using cyclosporin A, α-cyclodextrin and quaternary chitosan N-betainate

Janne Mannila; Kristiina Järvinen; Jukka Holappa; Laura Matilainen; Seppo Auriola; Pekka Jarho

Systemic drug delivery through intraoral membranes may offer a promising administration route for lipophilic peptide drugs. The aim of the present study was to investigate the effect of alpha-cyclodextrin (alpha-CD) and a novel chitosan derivative, chitosan N-betainate (CH), on sublingual absorption of a hydrophobic model peptide cyclosporin A (CsA), and the effect of temperature on the complexation of CsA with alpha-CD. Complexation of CsA with alpha-CD was studied using the phase-solubility method. Sublingual absorption of CsA was studied by administration of solid CsA/alpha-CD complex (with and without CH solution), solid CsA/alpha-CD/CH formulation and solid plain CsA to rabbits. The solubility of CsA in aqueous alpha-CD solution (14%) increased with decreasing temperature; the solubility of CsA at room temperature, +5 and +1 degrees C was 1.2, 12 and 19mg/ml, respectively. The bioavailability of CsA after administration of plain CsA, solid CsA/alpha-CD and solid CsA/alpha-CD/CH (0.6+/-0.5, 1.4+/-0.7 and 1.7+/-0.8%, respectively; mean+/-S.D.) was further increased when solid CsA/alpha-CD was administered together with CH solution (3.2+/-2.2%). The present study shows that decreased temperature can be effectively utilized to produce CsA/alpha-CD complexes. It was also shown that alpha-CD and CH may be advantageous in sublingual delivery of lipophilic peptides, although the absolute bioavailability remains low.


Journal of Pharmacy and Pharmacology | 2011

Fast‐dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits

Elina Turunen; Janne Mannila; Riikka Laitinen; Joakim Riikonen; Vesa-Pekka Lehto; Tomi Järvinen; Jarkko Ketolainen; Kristiina Järvinen; Pekka Jarho

Objectives  The sublingual administration route as well as solid dispersion formation with macrogol 8000 and complexation with β‐cyclodextrin (β‐CyD) were investigated as ways for improving the absorption of perphenazine, a poorly water‐soluble drug subjected to substantial first‐pass metabolism.


European Journal of Pharmaceutical Sciences | 2005

Effects of RM-β-CD on sublingual bioavailability of Δ9-tetrahydrocannabinol in rabbits

Janne Mannila; Tomi Järvinen; Kristiina Järvinen; Maarit Tarvainen; Pekka Jarho


Life Sciences | 2006

Sublingual administration of Δ9-tetrahydrocannabinol /β -cyclodextrin complex increases the bioavailability of Δ9-tetrahydrocannabinol in rabbits

Janne Mannila; Tomi Järvinen; Kristiina Järvinen; Jussi Tervonen; Pekka Jarho


Journal of Pharmaceutical Sciences | 2007

Precipitation complexation method produces cannabidiol/β-cyclodextrin inclusion complex suitable for sublingual administration of cannabidiol

Janne Mannila; Tomi Järvinen; Kristiina Järvinen; Pekka Jarho


Journal of Chromatography B | 2004

Determination of Δ9-tetrahydrocannabinol from rabbit plasma by gas chromatography–mass spectrometry using two ionization techniques

Janne Mannila; Marko Lehtonen; Tomi Järvinen; Pekka Jarho


Archive | 2003

Novel methylated cyclodextrin complexes

Tomi Järvinen; Janne Mannila; Pekka Jarho


Archive | 2003

Novel natural cyclodextrin complexes

Pekka Jarho; Janne Mannila; Tomi Järvinen


Archive | 2003

Methylated cyclodextrin complexes

Tomi Järvinen; Janne Mannila; Pekka Jarho


Archive | 2003

Natural cyclodextrin complexes

Pekka Jarho; Janne Mannila; Tomi Järvinen

Collaboration


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Pekka Jarho

University of Eastern Finland

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Tomi Järvinen

University of Eastern Finland

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Kristiina Järvinen

University of Eastern Finland

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Tomi Järvinen

University of Eastern Finland

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Elina Turunen

University of Eastern Finland

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Jarkko Ketolainen

University of Eastern Finland

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Joakim Riikonen

University of Eastern Finland

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Marko Lehtonen

University of Eastern Finland

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Riikka Laitinen

University of Eastern Finland

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Seppo Auriola

University of Eastern Finland

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