Jason Z. Zhang | Researchain

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Featured researches published by Jason Z. Zhang.

Bioorganic & Medicinal Chemistry | 2007

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: Highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate

Ken-ichi Yoshida; Kiyoshi Nakayama; Masami Ohtsuka; Noriko Kuru; Yoshihiro Yokomizo; Atsunobu Sakamoto; Makoto Takemura; Kazuki Hoshino; Hiroko Kanda; Hironobu Nitanai; Kenji Namba; Kumi Yoshida; Yuichiro Imamura; Jason Z. Zhang; Ving J. Lee; William J. Watkins

Bioorganic & Medicinal Chemistry Letters | 2003

MexAB-OprM-Specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization

Kiyoshi Nakayama; Yohei Ishida; Masami Ohtsuka; Haruko Kawato; Ken-ichi Yoshida; Yoshihiro Yokomizo; Shigeru Hosono; Toshiharu Ohta; Kazuki Hoshino; Hiroko Ishida; Kumi Yoshida; Thomas E. Renau; Roger Leger; Jason Z. Zhang; Ving J. Lee; William J. Watkins

Bioorganic & Medicinal Chemistry Letters | 2003

The relationship between physicochemical properties, in vitro activity and pharmacokinetic profiles of analogues of diamine-containing efflux pump inhibitors.

William J. Watkins; Yakira Landaverry; Roger Leger; Renee Litman; Thomas E. Renau; Nicole Williams; Rose Yen; Jason Z. Zhang; Suzanne Chamberland; Deidre Madsen; David A. Griffith; Vrushali Tembe; Keith Huie; Michael N. Dudley

Bioorganic & Medicinal Chemistry Letters | 2004

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

Kiyoshi Nakayama; Haruko Kawato; Jun Watanabe; Masami Ohtsuka; Ken-ichi Yoshida; Yoshihiro Yokomizo; Atsunobu Sakamoto; Noriko Kuru; Toshiharu Ohta; Kazuki Hoshino; Kumi Yoshida; Hiroko Ishida; Aesop Cho; Monica H. Palme; Jason Z. Zhang; Ving J. Lee; William J. Watkins

Bioorganic & Medicinal Chemistry | 2006

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position

Ken-ichi Yoshida; Kiyoshi Nakayama; Noriko Kuru; Shozo Kobayashi; Masami Ohtsuka; Makoto Takemura; Kazuki Hoshino; Hiroko Kanda; Jason Z. Zhang; Ving J. Lee; William J. Watkins

Bioorganic & Medicinal Chemistry | 2006

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: exploration of aromatic substituents.

Ken-ichi Yoshida; Kiyoshi Nakayama; Yoshihiro Yokomizo; Masami Ohtsuka; Makoto Takemura; Kazuki Hoshino; Hiroko Kanda; Kenji Namba; Hironobu Nitanai; Jason Z. Zhang; Ving J. Lee; William J. Watkins

Bioorganic & Medicinal Chemistry Letters | 2004

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

Kiyoshi Nakayama; Noriko Kuru; Masami Ohtsuka; Yoshihiro Yokomizo; Atsunobu Sakamoto; Haruko Kawato; Ken-ichi Yoshida; Toshiharu Ohta; Kazuki Hoshino; Junko Itoh; Hiroko Ishida; Aesop Cho; Monica H. Palme; Jason Z. Zhang; Ving J. Lee; William J. Watkins

Archive | 2000

Drug discharge pump inhibitors

Yohhei Ishida; Haruko Kawato; Ving J. Lee; Roger Leger; Kiyoshi Nakayama; Toshiharu Ohta; Masami Ohtsuka; Thomas E. Renau; William J. Watkins; Jason Z. Zhang

Archive | 2002