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Jay E. Wrobel

Cornell University

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Tetrahedron Letters | 1981

A general, highly stereoselective synthesis of amines

Jay E. Wrobel; Bruce Ganem

Abstract The stereochemical course of cycloalkanone imine reductions by a variety of boron hydride reagents is described; very high stereoselectivity with substituted alkali metal borohydrides is reported.

Journal of the American Chemical Society | 1984

Mechanism and synthetic utility of boron trifluoride etherate promoted organolithium additions

Michael J. Eis; Jay E. Wrobel; Bruce Ganem

Journal of Medicinal Chemistry | 1999

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3- d]thiophenes

Jay E. Wrobel; Janet Sredy; Christopher Moxham; Arlene Dietrich; Zenan Li; Diane R. Sawicki; Laura Seestaller; Li Wu; Alan H. Katz; Donald Sullivan; Cesario Tio; Zhong Yin Zhang

Journal of Medicinal Chemistry | 1992

Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents

Jay E. Wrobel; Arlene Dietrich; Shiela A. Woolson; Jane Millen; Michael L. McCaleb; Maria C. Harrison; Thomas C. Hohman; Janet Sredy; Donald Sullivan

Archive | 1999

Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin-resistance and hyperglycemia

Jay E. Wrobel; Arlene Dietrich; Madelene Miyoko Antane

Journal of Organic Chemistry | 1983

Total synthesis of (−)-vertinolide. A general approach to chiral tetronic acids and butenolides from allylic alcohols

Jay E. Wrobel; Bruce Ganem

Archive | 1999

11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia

Jay E. Wrobel; Arlene Dietrich; Zenan Li

Archive | 1999

Naphtho[2,3-b]heteroar-4-yl derivatives

Paul Jeffrey Dollings; Arlene Dietrich; Jay E. Wrobel

Journal of Organic Chemistry | 1990

Conformationally rigid analogs of aldose reductase inhibitor, tolrestat. Novel syntheses of naphthalene-fused .gamma.-, .delta.-, and .epsilon.-lactams

Jay E. Wrobel; Arlene Dietrich; Beverly J. Gorham; Kazimir Sestanj

Archive | 1988

N-acyl-N-naphthoylglycines as aldose reductase inhibitors

Kazimir Sestanj; Jay E. Wrobel; Joseph M. Kelly

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Arlene Dietrich

Princeton University

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Zenan Li

Princeton University

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Bruce Ganem

Cornell University

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Donald Sullivan

Princeton University

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Janet Sredy

Princeton University

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Paul Jeffrey Dollings

Princeton University

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Alan H. Katz

Princeton University

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Diane R. Sawicki

Princeton University

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Iwan Gunawan

Princeton University

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Jane Millen

Princeton University

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