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Zenan Li

Princeton University

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Publication

Featured researches published by Zenan Li.

Bioorganic & Medicinal Chemistry Letters | 2000

Synthesis and PTP1B Inhibition of Novel 4-Aryl-1-Oxa-9-Thiacyclopenta[b]fluorenes

Jay Wrobel; Zenan Li; Janet Sredy; Diane R. Sawicki; Laura Seestaller; Donald Sullivan

Novel 4-aryl-1-oxa-9-thiacyclopenta[b]fluorenes were designed, synthesized, and evaluated as inhibitors of the protein tyrosine phosphatase, PTP1B. Compounds 3 (IC50 = 284 nM) and 4 (IC50 = 74 nM), showed nanomolar potency against PTP1B (TRDI(P)YETD(P)Y(P)YRK as substrate). Compound 4 also lowered insulin in the diabetic ob/ob mouse at a dose of 10 mg/kg/day, p.o.

Journal of Medicinal Chemistry | 1999

PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3- d]thiophenes

Jay E. Wrobel; Janet Sredy; Christopher Moxham; Arlene Dietrich; Zenan Li; Diane R. Sawicki; Laura Seestaller; Li Wu; Alan H. Katz; Donald Sullivan; Cesario Tio; Zhong Yin Zhang

Archive | 1999

11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia

Jay E. Wrobel; Arlene Dietrich; Zenan Li

Journal of Medicinal Chemistry | 1998

Novel 5-(3-aryl-2-propynyl)-5-(arylsulfonyl)thiazolidine-2,4-diones as antihyperglycemic agents.

Jay Wrobel; Zenan Li; Arlene Dietrich; Michael L. McCaleb; Brenda Mihan; Janet Sredy; Donald Sullivan

Archive | 2000

4-aryl-1-oxa-9-thia-cyclopenta (b) fluorenes

Jay E. Wrobel; Zenan Li

Archive | 2002

Azolidines as beta-3 adrenergic receptor agonists

Michael Sotirios Malamas; Elwood E. Largis; Iwan Gunawan; Zenan Li

Archive | 1999

1-aryl-dibenzothiophenes

Jay E. Wrobel; Arlene Dietrich; Zenan Li

Archive | 1995

Certain-[3-aryl-prop-2-ynyl]-5-(arylsulfonyl) thiazolidine -2,4-dione derivatives

Jay E. Wrobel; Zenan Li; Arlene Dietrich

Archive | 1995

Anti-hyperglycemic agents

Jay E. Wrobel; Zenan Li; Arlene Dietrich

Archive | 1995

Thiazolidinedione derivatives as anti-hyperglycemic agents

Jay E. Wrobel; Zenan Li; Arlene Dietrich

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Collaboration

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Arlene Dietrich

Princeton University

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Jay E. Wrobel

Cornell University

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Donald Sullivan

Princeton University

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Iwan Gunawan

Princeton University

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Janet Sredy

Princeton University

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Diane R. Sawicki

Princeton University

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Elwood E. Largis

University of North Dakota

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Jay Wrobel

Princeton University

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Laura Seestaller

Princeton University

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Alan H. Katz

Princeton University

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