Jaya Sharma

Retraction Note: Development and In Vitro-In Vivo Characterization of Chronomodulated Pulsatile Delivery Formulation of Terbutaline Sulphate by Box-Behnken Statistical Design

This article has been retracted by the journal because the editors have clear evidence that the scientific findings in this article are unreliable.

Preparation and Characterisation of Telmisartan Solid Dispersions Prepared by Solvent Evaporation Method

Enhancement of the solubility and dissolution of Telmisartan using solid dispersion (SD) with PVP K-90, PVP K-30 and Eudragit RS-100 by a solvent evaporation technique. In this method, SDs were prepared by the solvent evaporation method using minimum quantity of ethanol. Infrared (IR) spectroscopy was performed to identify physio-chemical interaction between the drug and the polymers, and differential scanning calorimetry (DSC) was performed to identify the melting point of SDs and their effect on dissolution behaviour. Morphology of the SDs was studied using scanning electron microscopy (SEM) and powdered X-ray diffractometry (PXRD). A comparative evaluation of the dissolution of Telmisartan SDs, pure drug and marketed formulation (tablet) was carried out. In the Results section, dissolution of Telmisartan significantly improved in SDs as compared to the pure drug. Telmisartan exhibited better aqueous solubility in the presence of all the polymers used. IR spectroscopy and DSC showed no change in the crystal structure of Telmisartan. It was concluded that SD prepared by the solvent evaporation method can be successfully used for the improvement of dissolution of Telmisartan.

Formulation and ex vivo–in vivo evaluation of pH-triggered brimonidine tartrate in situ gel for the glaucoma treatment using application of 32 factorial design

Abstract Context: Short residence time, poor bioavailability and poor permeability are the major problems for conventional eye drops treatment. Objective: The aim of this article is to develop, optimize and ex vivo–in vivo investigation of brimonidine tartrate in situ gel as compared to marketed eye drops for the treatment of glaucoma. Materials and methods: The effect of independent variables, namely concentrations of polymers, on various dependent variables like viscosity at physiological pH and in vitro drug release were studied by using 32 factorial design. Further the optimized formulation was characterized for ex vivo and in vivo study. Results and discussion: Experimental data demonstrated that optimized in situ gel formulation (F8) showed in vitro–ex vivo sustained release profile with polymer composites carbopol 974P and HPMC K4M. After 5 h of ex vivo transcorneal permeation study, the amount recovered from the corneal surface on the donor chamber 12.40% (124 ug) and the amount collected from the receptor chamber 76.8% (760 ug) of the initial dose 1 mg. The total amount recovered from the permeation experiment was 89.2%. Bioadhesive carbopol 974P and viscosity HPMC K4M composites optimized formulation (F 8) produce greater influence on the duration of drug action and improved intraocular pressure reduction activity as compared to marketed eye drop solution in in vivo study. Conclusion: The developed in situ gelling system as a promising ophthalmic formulation to prolong the drug lowering effect on the intraocular pressure.

Health Booster – Herbal Teas

Theres nothing better than a soothing cup of herbal tea on a cold midwinters day. But besides being a tasty, warming, caffeine-free pick-me-up, herbal tea has lots of wonderful health benefits. From soothing a troubled tummy to easing insomnia and calming a troubled mind, herbs have all sorts of healing powers. Drinking herbal tea can also be a great source of vitamins and minerals. Herbal tea is not really made from tea which is a specific kind of plant. The French use the word tisane, which is a little more accurate, as herbal tea is really just an infusion of leaves, seeds, roots or bark, extracted in hot water. By drinking a well-steeped herbal tea, all the plants benefit in an easily digestible form. When it comes to choosing an herbal tea it is important to look for a well-sourced product made from high-quality ingredients. The tea, for the medicinal benefits, definitely steers clear of products that add things like essential oils or flavours. To really get the full benefits from drinking herbal tea, Dixon says “If you drink tea every day, you can make all sorts of significant changes to your mood, your skin, your sense of well-being make sure you steep your loose tea or tea bags long enough – in some cases, as long as 10 to 15 min – to really bring out all the healthful properties.” There are so many wonderful herbal teas to choose from Peppermint tea, Ginger tea, Chamomile tea, Rooibos tea, Lemon tea, Milk thistle and dandelion tea and Rosehip tea. Each herbal tea is designed for a specific medical or therapeutic benefit. General benefits achieved by consuming herbal tea are, relaxation of mind, supports the health of the heart, help in digestion, cleansing properties of the body, promote overall health and wellness, nourishes the nervous system, immunity is built, relieves stress, immunity against colds, stimulates the internal organs and induces proper sleep during the night.