Jayadevan Jayashankaran

Synthesis of Novel Ferrocenyl Oxindole and Ferrocene Substituted Dispiroheterocycles Through [3+2]Cycloaddition of Azomethine Ylides

Abstract Synthesis of novel ferrocenyl oxindoles was successfully achieved, and a series of novel dispiroheterocyclic system has been synthesized by the cycloaddition of azomethine ylides generated by the decarboxylative route from secondary amino acids (sarcosine/proline) and isatin/acenaphthequinone/ninhydrin with the newly synthesized ferrocenyl oxindole. All of the cycloaddition reactions gave ferrocenyl substituted pyrrolidine/pyrrolizidine derivatives with very high regio and stereoselectivity in reasonable yiels.

An Easy Access to Spiroisoxazoline [5,31] Flavan-41-one Through 1,3-Dipolar Cycloaddition Reaction of Nitrile Oxide to Unusual Dipolarophiles

Abstract Synthesis of a series of novel spiro[3,4-diaryl-4,5-dihydroisoxazole-5,31-flavan-41-one] has been accomplished in good yields by the regioselective 1,3-dipolar cycloaddition reaction of nitrile oxide to 3-arylmethylidene flavan-4-ones.

A New Access to Dispiro 7-Oxaindazolidines Spiroxindole Derivatives

Abstract Synthesis of dispiro 7-oxaindazolidines has been accomplished by regioselective 1,3-dipoiar cycloaddition reaction of azomethine ylide generated from secondary amine, morpholine, and isatin (via deprotonation route) with arylidene chromanones and arylidene tetralones as dipolarophiles.

Novel Synthesis of N‐Methyl Spiropyrrolidines by 1,3‐Dipolar Cycloaddition Reaction of Azomethine Ylides

Abstract A series of novel N‐methyl spiropyrrolidines have been synthesized in good yield by the cycloaddition reaction of azomethine ylides generated by a decarboxylative route from sarcosine and paraformaldehyde with conformationally locked s‐trans enone functionality present in the (E)‐3‐arylidene‐4‐chromanone as dipolarophiles. The structure of the title compound was established by spectroscopic techniques.

A novel entry into a new class of dispiroheterocycles through azomethine ylides involving unusual dipolarophiles

Abstract The cycloaddition reaction of azomethine ylides towards (E)-3-arylidene-4-chromanone as new dipolarophile has been investigated. High degree of regioselectivity has been observed in the synthesis of a new class of functionalized dispiroheterocyclic pyrrolidines bearing chromanone and acenaphthenequinone framework.