Rathna Durga R.S. Manian

Synthesis and antibacterial property of quinolines with potent DNA gyrase activity.

Synthesis of a series of novel tetrahydroquinoline annulated heterocycles has been accomplished by intramolecular imino and bisimino Diels-Alder reaction. These compounds were evaluated for their antibacterial activity. All the synthetic compounds, exhibited good antibacterial activity against microorganisms of which one of them 7 was found to be as active as the antibiotic ciplofloxacin and is found to have MIC value of 2.5 mg/mL against Escherichia coli.

Synthesis of Novel Ferrocenyl Oxindole and Ferrocene Substituted Dispiroheterocycles Through [3+2]Cycloaddition of Azomethine Ylides

Abstract Synthesis of novel ferrocenyl oxindoles was successfully achieved, and a series of novel dispiroheterocyclic system has been synthesized by the cycloaddition of azomethine ylides generated by the decarboxylative route from secondary amino acids (sarcosine/proline) and isatin/acenaphthequinone/ninhydrin with the newly synthesized ferrocenyl oxindole. All of the cycloaddition reactions gave ferrocenyl substituted pyrrolidine/pyrrolizidine derivatives with very high regio and stereoselectivity in reasonable yiels.

A New Access to Dispiro 7-Oxaindazolidines Spiroxindole Derivatives

Abstract Synthesis of dispiro 7-oxaindazolidines has been accomplished by regioselective 1,3-dipoiar cycloaddition reaction of azomethine ylide generated from secondary amine, morpholine, and isatin (via deprotonation route) with arylidene chromanones and arylidene tetralones as dipolarophiles.