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Dive into the research topics where Jayne Franklyn is active.

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Featured researches published by Jayne Franklyn.


Society for Endocrinology BES 2014 | 2014

Inhibition of radioiodine uptake by PBF in breast cells is consistent with sodium-iodide symporter repression in the thyroid

Vikki Poole; Martin Read; Rachel Watkins; Bhavika Modasia; Gavin Ryan; Kristien Boelaert; Jayne Franklyn; Vicki Smith; Christopher McCabe

Previous studies in thyroid cells have shown that pituitary tumor-transforming gene (PTTG) binding factor (PBF), is capable of altering the subcellular localisation of NIS and sequestering it in cytoplasmic vesicles (2). This interaction can be abrogated by inhibiting the phosphorylation of PBF at tyrosine residue 174 using the Src inhibitor PP1. Mutants of PBF without this key residue are also unable to bind and sequester NIS (3).


Archive | 1988

Clinical endocrinology and diabetes

M. C. Sheppard; Jayne Franklyn


Society for Endocrinology BES 2012 | 2012

PBF interacts with cortactin and thyroglobulin in thyroid cells

Neil Sharma; Vicki Smith; Rob Seed; Martin Read; Gregory Lewy; Gavin Ryan; Jim Fong; Perkin Kwan; John Watkinson; Ashley Martin; Kristien Boelaert; Jayne Franklyn; Christopher McCabe


Society for Endocrinology BES 2008 | 2008

Propylthiouracil (PTU) induced agranulocytosis in pregnancy

Ateeq Syed; Srinivasa Rangan; Jayne Franklyn


Society for Endocrinology BES 2008 | 2008

Expression of thyroid hormone transporters in human placenta and changes with intrauterine growth restriction (IUGR)

Shiao Chan; Laurence Loubiere; Elisavet Vasilopoulou; Christopher McCabe; Jayne Franklyn; Mark D. Kilby


Society for Endocrinology BES | 2007

Using an increased fixed dose of 131 I (600MBq) leads to improved outcome in patients with hyperthyroidism

Kristien Boelaert; N. Manji; M. C. Sheppard; S. C. L. Gough; Jayne Franklyn


Archive | 2017

The restoration of serum TSH to within the reference range should be the goal of replacement therapy

Mark Vanderpump; Jayne Franklyn


Endocrine Abstracts | 2016

Post-Radioiodine Graves' Management: The Pragma-Study

Petros Perros; Colin Mark Dayan; Bijay Vaidya; Graham R. Williams; John H. Lazarus; Janis Hickey; Debbie Willis; Natasha Archer; Jayne Franklyn; Ansu Basu


Society for Endocrinology BES 2014 | 2014

ATR kinase function is modulated by the proto-oncogene PBF

Hui Fan; Teresa Gagliano; Martin Read; Jayne Franklyn; Kristien Boelaert; Andrew Turnell; Christofer J McCabe


Society for Endocrinology BES 2014 | 2014

PBF is a component of the molecular signalling pathways that drive hyperplastic and neoplastic thyroid growth

Vicki Smith; Martin Read; Rachel Watkins; Vikki Poole; Bhavika Modasia; Waraporn Imruetaicharoenchoke; Kristien Boelaert; Jayne Franklyn; Christopher McCabe

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Vicki Smith

University of Birmingham

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Martin Read

University of Birmingham

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Gavin Ryan

University of Birmingham

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Neil Sharma

University of Birmingham

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Robert Seed

University of Birmingham

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Jim Fong

University of Birmingham

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Perkin Kwan

University of Birmingham

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Gregory Lewy

University of Birmingham

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