Jean-Adolphe Rondal

Current perspectives on developmental dysphasias

Abstract The paper documents the major difficulties observed in the oral language development of individuals with mental retardation of genetic origin. The extent of inter- and within-syndrome variability is evaluated. More specifically, a comparative analysis of typical language phenotypes in several genetic syndromes is attempted and the possible brain underpinnings of the observed differences are envisaged. Recent cases of favorable language development in individuals with mental retardation are summarized and explanatory variables are discussed.

Neurocognitive rehabilitation of Down syndrome : the early years

Preface Part I. Definition, History, Methodology, and Assessment: 1. Early intervention: definition, objectives, models and challenges Juan Perera 2. The history of rehabilitative intervention for infants and young children with Down syndrome and their families: where have we been and where are we going? Donna Spiker 3. Advances in clinical endpoints for neurocognitive rehabilitation in Down syndrome Jamie Edgin, Goffredina Spano and Lynne Nadel Part II. Genetics, Brain and Animal Models: 4. New perspectives on molecular and genetic therapies in Down syndrome Jean-Maurice Delabar 5. Brain plasticity and environmental enrichment in Ts65Dn mice, an animal model for Down syndrome Adam Golabek, Katarzyna Jarzabek, Sonia Palminiello, Marius Walus, Ausma Rabe, Giorgio Albertini and Elizabeth Kida 6. Development of the brain and metabolism David Patterson Part III. Pharmacological and Medical Management and Treatment: 7. Pharmacotherapy for children with Down syndrome George Capone 8. Early medical caretaking and follow-up Alberto Rasore-Quartino 9. Evaluation and management of cardiovascular diseases in Down syndrome Guy Dembour and Stephane Moniotte Part IV. Early Development and Intervention: 10. Developmental models as frameworks for early intervention with children with Down syndrome Katie Cohene, Heidi Flores and Jacob Burack 11. Aspects of motor development in Down syndrome Naznin Virji-Babul, Anne Jobling, Digby Elliot and Daniel Weeks 12. Memory development and learning Stefano Vicari and Deny Menghini 13. Prelinguistic and early development, stimulation and training in children with Down syndrome Jean-Adolphe Rondal 14. Speech perception, stimulation and phonological development Michele Pettinato 15. Goal-directedness as a target for early intervention in Down syndrome Deborah Fidler, Susan L. Hepburn and Diane Osaki 16. The role of parents of children with Down syndrome and other disabilities in early intervention Gerald Mahoney and Frida Perales Part V. Therapeutic Perspectives: 17. Perspectives of hybrid therapeutic strategies in intellectual disabilities and Down syndrome Jean-Adolphe Rondal and Juan Perera Conclusions Index.

La morfosintaxis de los enunciados: ¿categorías lingüísticas de la profundidad a la superficie o regulaciones en línea sobre base pragmático-semántica?

Resumen Una idea muy extendida en la psicologia del lenguaje considera que las categorias formales y funcionales utilizadas en linguistica estructural para describir los hechos de lengua tienen realidad psicologica para la organizacion de los enunciados. A continuacion demostramos que esta creencia no es sostenible. Una orientacion teorica alternativa preve una traduccion directa de las relaciones de significado, proporcionadas por una matriz semantica que interviene dentro de un marco pragmatico, en secuencias lexicas de superficie; y los registros productivos se constituyen a traves de analogias sustitutivas aprendidas de forma implicita. Esta afirmacion, mucho mas cerca de la opinion de los partidarios de las neurociencias cognitivas, tiene importantes implicaciones para la terapia de rehabilitacion en logopedia de la morfosintaxis.

Especificidad neuroconductual en el síndrome de Down

Resumen La identificacion de un numero cada vez mayor de sindromes geneticos que causan una incapacidad intelectual grave —gracias a nuevos progresos realizados en el campo de la genetica molecular— nos lleva a analizar las similaridades y las disimilaridades existentes entre los distintos sindromes. Este estudio sugiere un alto grado de especificidad neuroconductual asociada al sindrome de Down, el sindrome del retraso mental mas conocido actualmente. Tener en cuenta tal especificidad es de gran importancia tanto para la investigacion neurocognitiva como para la practica clinica. En los ultimos anos se han identificado centenares de sindromes geneticos que llevan a un importante grado de incapacidad intelectual ( Dykens, 1995 ; Shprintzen, 1997 ). Las incapacidades intelectuales de origen genetico representan alrededor del 30% de los casos de retraso mental moderado o grave. Dados nuestros conocimientos (cada vez mayores) sobre un numero de sindromes geneticos del retraso mental (v. Dykens, Hodapp y Finucane, 2000; Rondal, Hodapp, Soresi, Dykens y Nota, 2004), es pertinente preguntarse hasta que punto dichos sindromes presentan caracteristicas identicas o especificas. La especificidad, es decir la propiedad de una cosa de tener caracteristicas particulares o unicas, puede definirse bajo dos niveles distintos ( Rondal, 1995a ): 1. El nivel de los sintomas o de las caracteristicas aisladas. 2. Un nivel mas global, sistemico o sindromico, que no se centra tanto en los sintomas aislados sino en los perfiles anatomofisiologicos de ciertas fuerzas y debilidades que caracterizan las entidades patologicas. Todavia existe otro nivel en el cual, a partir de los perfiles especificos, se comparan las vias de desarrollo entre dos sindromes distintos, es decir el modo en que los ritmos de desarrollo y los perfiles de determinadas fuerzas y debilidades pueden variar de un periodo de desarrollo a otro (p. ej., se ha sugerido que en el sindrome del cromosoma X fragil, una patologia ligada al cromosoma X, tendria lugar una ralentizacion significativa del desarrollo en el periodo de la adolescencia [Hodapp, Dykens, Hagerman, Schreiner, Lachiewicz y Leckman, 1990]).

Aspectos morfosintácticos avanzados del lenguaje de niños y adolescentes con retraso mental leve y moderado

Resumen Se expone el caso de una nina de tres anos de edad que acude a consulta a un centro de psiquiatria y psicologia infantil por ausencia de lenguaje. A traves de las primeras entrevistas y de la exploracion se detectan dificultades tanto a nivel de la expresion oral como en los aspectos de relacion y emocionales. Se inicia un tratamiento que estimule ambas areas conjuntamente. Se describe la evolucion de la paciente durante el primer ano de terapia haciendo especial mencion de como la maduracion psiquica y la capacidad de expresarse a nivel verbal de una forma progresivamente mas adecuada a su entorno, caminan muy relacionadas y de como una y otra son, en este caso, absolutamente interdependientes.

Morphosyntactical Difficulties and Rehabilitation in Persons with Down Syndrome

Abstract Morphosyntactical limitations are noteworthy in persons with Down syndrome but no comprehensive explanation has been proposed yet. We summarize the work conducted over several decades of research and propose an explanation grounded in procedural implicit learning and implicit memory. It is argued that the morphosyntactical limitations of persons with Down syndrome stem from an underdevelopment of particular brain regions with predictable learning consequences. A specific rehabilitation strategy is defined with the aim of enhancing grammatical functioning in these persons.

Neurocognitive Rehabilitation of Down Syndrome: Index

Preface Part I. Definition, History, Methodology, and Assessment: 1. Early intervention: definition, objectives, models and challenges Juan Perera 2. The history of rehabilitative intervention for infants and young children with Down syndrome and their families: where have we been and where are we going? Donna Spiker 3. Advances in clinical endpoints for neurocognitive rehabilitation in Down syndrome Jamie Edgin, Goffredina Spano and Lynne Nadel Part II. Genetics, Brain and Animal Models: 4. New perspectives on molecular and genetic therapies in Down syndrome Jean-Maurice Delabar 5. Brain plasticity and environmental enrichment in Ts65Dn mice, an animal model for Down syndrome Adam Golabek, Katarzyna Jarzabek, Sonia Palminiello, Marius Walus, Ausma Rabe, Giorgio Albertini and Elizabeth Kida 6. Development of the brain and metabolism David Patterson Part III. Pharmacological and Medical Management and Treatment: 7. Pharmacotherapy for children with Down syndrome George Capone 8. Early medical caretaking and follow-up Alberto Rasore-Quartino 9. Evaluation and management of cardiovascular diseases in Down syndrome Guy Dembour and Stephane Moniotte Part IV. Early Development and Intervention: 10. Developmental models as frameworks for early intervention with children with Down syndrome Katie Cohene, Heidi Flores and Jacob Burack 11. Aspects of motor development in Down syndrome Naznin Virji-Babul, Anne Jobling, Digby Elliot and Daniel Weeks 12. Memory development and learning Stefano Vicari and Deny Menghini 13. Prelinguistic and early development, stimulation and training in children with Down syndrome Jean-Adolphe Rondal 14. Speech perception, stimulation and phonological development Michele Pettinato 15. Goal-directedness as a target for early intervention in Down syndrome Deborah Fidler, Susan L. Hepburn and Diane Osaki 16. The role of parents of children with Down syndrome and other disabilities in early intervention Gerald Mahoney and Frida Perales Part V. Therapeutic Perspectives: 17. Perspectives of hybrid therapeutic strategies in intellectual disabilities and Down syndrome Jean-Adolphe Rondal and Juan Perera Conclusions Index.

Neurocognitive Rehabilitation of Down Syndrome: Contents

Preface Part I. Definition, History, Methodology, and Assessment: 1. Early intervention: definition, objectives, models and challenges Juan Perera 2. The history of rehabilitative intervention for infants and young children with Down syndrome and their families: where have we been and where are we going? Donna Spiker 3. Advances in clinical endpoints for neurocognitive rehabilitation in Down syndrome Jamie Edgin, Goffredina Spano and Lynne Nadel Part II. Genetics, Brain and Animal Models: 4. New perspectives on molecular and genetic therapies in Down syndrome Jean-Maurice Delabar 5. Brain plasticity and environmental enrichment in Ts65Dn mice, an animal model for Down syndrome Adam Golabek, Katarzyna Jarzabek, Sonia Palminiello, Marius Walus, Ausma Rabe, Giorgio Albertini and Elizabeth Kida 6. Development of the brain and metabolism David Patterson Part III. Pharmacological and Medical Management and Treatment: 7. Pharmacotherapy for children with Down syndrome George Capone 8. Early medical caretaking and follow-up Alberto Rasore-Quartino 9. Evaluation and management of cardiovascular diseases in Down syndrome Guy Dembour and Stephane Moniotte Part IV. Early Development and Intervention: 10. Developmental models as frameworks for early intervention with children with Down syndrome Katie Cohene, Heidi Flores and Jacob Burack 11. Aspects of motor development in Down syndrome Naznin Virji-Babul, Anne Jobling, Digby Elliot and Daniel Weeks 12. Memory development and learning Stefano Vicari and Deny Menghini 13. Prelinguistic and early development, stimulation and training in children with Down syndrome Jean-Adolphe Rondal 14. Speech perception, stimulation and phonological development Michele Pettinato 15. Goal-directedness as a target for early intervention in Down syndrome Deborah Fidler, Susan L. Hepburn and Diane Osaki 16. The role of parents of children with Down syndrome and other disabilities in early intervention Gerald Mahoney and Frida Perales Part V. Therapeutic Perspectives: 17. Perspectives of hybrid therapeutic strategies in intellectual disabilities and Down syndrome Jean-Adolphe Rondal and Juan Perera Conclusions Index.

Neurocognitive Rehabilitation of Down Syndrome: Frontmatter

Preface Part I. Definition, History, Methodology, and Assessment: 1. Early intervention: definition, objectives, models and challenges Juan Perera 2. The history of rehabilitative intervention for infants and young children with Down syndrome and their families: where have we been and where are we going? Donna Spiker 3. Advances in clinical endpoints for neurocognitive rehabilitation in Down syndrome Jamie Edgin, Goffredina Spano and Lynne Nadel Part II. Genetics, Brain and Animal Models: 4. New perspectives on molecular and genetic therapies in Down syndrome Jean-Maurice Delabar 5. Brain plasticity and environmental enrichment in Ts65Dn mice, an animal model for Down syndrome Adam Golabek, Katarzyna Jarzabek, Sonia Palminiello, Marius Walus, Ausma Rabe, Giorgio Albertini and Elizabeth Kida 6. Development of the brain and metabolism David Patterson Part III. Pharmacological and Medical Management and Treatment: 7. Pharmacotherapy for children with Down syndrome George Capone 8. Early medical caretaking and follow-up Alberto Rasore-Quartino 9. Evaluation and management of cardiovascular diseases in Down syndrome Guy Dembour and Stephane Moniotte Part IV. Early Development and Intervention: 10. Developmental models as frameworks for early intervention with children with Down syndrome Katie Cohene, Heidi Flores and Jacob Burack 11. Aspects of motor development in Down syndrome Naznin Virji-Babul, Anne Jobling, Digby Elliot and Daniel Weeks 12. Memory development and learning Stefano Vicari and Deny Menghini 13. Prelinguistic and early development, stimulation and training in children with Down syndrome Jean-Adolphe Rondal 14. Speech perception, stimulation and phonological development Michele Pettinato 15. Goal-directedness as a target for early intervention in Down syndrome Deborah Fidler, Susan L. Hepburn and Diane Osaki 16. The role of parents of children with Down syndrome and other disabilities in early intervention Gerald Mahoney and Frida Perales Part V. Therapeutic Perspectives: 17. Perspectives of hybrid therapeutic strategies in intellectual disabilities and Down syndrome Jean-Adolphe Rondal and Juan Perera Conclusions Index.

Neurocognitive Rehabilitation of Down Syndrome: Acknowledgments

Preface Part I. Definition, History, Methodology, and Assessment: 1. Early intervention: definition, objectives, models and challenges Juan Perera 2. The history of rehabilitative intervention for infants and young children with Down syndrome and their families: where have we been and where are we going? Donna Spiker 3. Advances in clinical endpoints for neurocognitive rehabilitation in Down syndrome Jamie Edgin, Goffredina Spano and Lynne Nadel Part II. Genetics, Brain and Animal Models: 4. New perspectives on molecular and genetic therapies in Down syndrome Jean-Maurice Delabar 5. Brain plasticity and environmental enrichment in Ts65Dn mice, an animal model for Down syndrome Adam Golabek, Katarzyna Jarzabek, Sonia Palminiello, Marius Walus, Ausma Rabe, Giorgio Albertini and Elizabeth Kida 6. Development of the brain and metabolism David Patterson Part III. Pharmacological and Medical Management and Treatment: 7. Pharmacotherapy for children with Down syndrome George Capone 8. Early medical caretaking and follow-up Alberto Rasore-Quartino 9. Evaluation and management of cardiovascular diseases in Down syndrome Guy Dembour and Stephane Moniotte Part IV. Early Development and Intervention: 10. Developmental models as frameworks for early intervention with children with Down syndrome Katie Cohene, Heidi Flores and Jacob Burack 11. Aspects of motor development in Down syndrome Naznin Virji-Babul, Anne Jobling, Digby Elliot and Daniel Weeks 12. Memory development and learning Stefano Vicari and Deny Menghini 13. Prelinguistic and early development, stimulation and training in children with Down syndrome Jean-Adolphe Rondal 14. Speech perception, stimulation and phonological development Michele Pettinato 15. Goal-directedness as a target for early intervention in Down syndrome Deborah Fidler, Susan L. Hepburn and Diane Osaki 16. The role of parents of children with Down syndrome and other disabilities in early intervention Gerald Mahoney and Frida Perales Part V. Therapeutic Perspectives: 17. Perspectives of hybrid therapeutic strategies in intellectual disabilities and Down syndrome Jean-Adolphe Rondal and Juan Perera Conclusions Index.