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Jean-Claude Arnould

AstraZeneca

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Publication

Featured researches published by Jean-Claude Arnould.

Bioorganic & Medicinal Chemistry Letters | 2012

Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: part 1.

Benedicte Delouvrie; Katherine Al-Kadhimi; Jean-Claude Arnould; Simon T. Barry; Darren Cross; Myriam Didelot; Paul R. Gavine; Hervé Germain; Craig S. Harris; Adina Hughes; David Jude; Jane Kendrew; Christine Lambert-van der Brempt; Jean-Jacques Marcel Lohmann; Morgan Ménard; Andrew Austen Mortlock; Martin Pass; Claire Rooney; Michel Vautier; Jennifer L. Vincent; Nicolas Warin

Potent antagonists of the integrin α(5)β(1), which are RGD mimetics built from tyrosine are described. This paper describes the optimization of in vitro potency obtained by variation of two parts of the molecule, the central aromatic core and the amide moiety.

Archive | 1999

Colchinol derivatives as vascular damaging agents

Peter David Davis; Jean-Claude Arnould; Francis Thomas Boyle

Archive | 2001

Indole derivatives with vascular damaging activity

Jean-Claude Arnould; Thomas Geoffrey Colerick Bird; Francis Thomas Boyle; David Charles Blakey

Archive | 2005

5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors

Malena Bengtsson; Joakim Larsson; Grigorios Nikitidis; Peter Storm; John Peter Bailey; Edward Jolyon Griffen; Jean-Claude Arnould; Thomas Geoffrey Colerick Bird

Archive | 1998

Imidazole derivatives and their use as farnesyl protein transferase inhibitors

Jean-Claude Arnould

Archive | 2007

THIAZOLE DERIVATIVES AND THEIR USE AS ANTI-TUMOUR AGENTS

Jean-Claude Arnould; Kevin Michael Foote; Edward Jolyon Griffen

Archive | 1998

Imidazolyl compounds as inhibitors of farnesyl-protein tranferase

Francis Thomas Boyle; Gareth M. Davies; James Michael Wardleworth; Jean-Claude Arnould

Archive | 2007

N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl]-l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors

Jean-Claude Arnould; Benedicte Delouvrie; Richard Ducray; Der Brempt Christine Marie Paul Lambert-Van

Tetrahedron | 2009

Fischer synthesis of isomeric thienopyrrole LHRH antagonists

David M. Andrews; Jean-Claude Arnould; Pascal Boutron; Benedicte Delouvrie; Christian Delvare; Kevin Michael Foote; Annie Hamon; Craig S. Harris; Christine Lambert-van der Brempt; Maryannick Lamorlette; Zbegniew M. Matusiak

Archive | 2005

3,4-disubstituted maleimides for use as vascular damaging agents

Jean-Claude Arnould; Craig S. Harris; Francis Thomas Boyle; Keith Hopkinson Gibson

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Collaboration

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Benedicte Delouvrie

AstraZeneca

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Thomas Geoffrey Colerick Bird

AstraZeneca

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Craig S. Harris

AstraZeneca

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Edward Jolyon Griffen

AstraZeneca

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Francis Thomas Boyle

Imperial Chemical Industries

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Grigorios Nikitidis

AstraZeneca

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Joakim Larsson

AstraZeneca

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John Peter Bailey

AstraZeneca

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Malena Bengtsson

AstraZeneca

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Peter Storm

AstraZeneca

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