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Joakim Larsson

AstraZeneca

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Publication

Featured researches published by Joakim Larsson.

Bioorganic & Medicinal Chemistry Letters | 2010

4-Anilino-6-phenyl-quinoline inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK2).

Henric Olsson; Peter Sjö; Oguz Ersoy; Anna Kristoffersson; Joakim Larsson; Bo Nordén

A class of inhibitors of mitogen activated protein kinase-activated kinase 2 (MK2) was discovered via high-throughput screening. This compound class demonstrates activity against the enzyme with sub-microM IC(50) values, and suppresses LPS-induced TNFalpha levels in THP-1 cells. MK2 inhibition kinetic measurements indicated mixed binding approaching non-ATP competitive inhibition.

Archive | 2005

5-Heteroaryl Thiazoles And Their Use As PI3K Inhibitors

Malena Bengtsson; Joakim Larsson; Grigorios Nikitidis; Peter Storm; John Peter Bailey; Edward Jolyon Griffen; Jean-Claude Arnould; Thomas Geoffrey Colerick Bird

Archive | 2002

Novel 4-anilinoquinoline-3-carboxamides

Joakim Larsson; Peter Sjö

Archive | 2003

2-pyridone derivatives as inhibitors of neutrophile elastase

Håkan Bladh; Tomas Klingstedt; Joakim Larsson; Karolina Lawitz; Matti Lepistö; Hans Lönn; Grigorios Nikitidis

Archive | 2004

Quinoxaline derivatives as neutrophil elastase inhibitors and their use

Haakan Bladh; Joakim Larsson

Archive | 2003

2-PYRIDONDERIVATE ALS INHIBITOREN VON NEUTROPHILER ELASTASE

Håkan Bladh; Tomas Klingstedt; Joakim Larsson; Karolina Lawitz; Matti Lepistö; Hans Lönn; Grigorios Nikitidis

Archive | 2002

4-anilinoquinoline-3-carboxamides

Joakim Larsson; Peter Sjö

Archive | 2005

DERIVADOS DE 2-PIRIDONA COMO INHIBIDORES DE LA ELASTASA DE LOS NEUTROFILOS.

Håkan Bladh; Tomas Klingstedt; Joakim Larsson; Karolina Lawitz; Matti Lepistoe; Hans Loenn; Grigorios Nikitidis

Archive | 2005

5-heteroarylthiazole and their use as PI3K inhibitors

Malena Bengtsson; Joakim Larsson; Grigorios Nikitidis; Peter Storm; John Peter Bailey; Edward Jolyon Griffen; Jean-Claude Arnould; Thomas Geoffrey Colerick Bird

Archive | 2005

5-heteroarylthiazole und deren verwendung als pi3k-inhibitoren 5-heteroarylthiazole and their use as PI3K inhibitors

Malena Bengtsson; Joakim Larsson; Grigorios Nikitidis; Peter Storm; John Peter Bailey; Edward Jolyon Griffen; Jean-Claude Arnould; Thomas Geoffrey Colerick Bird

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Collaboration

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Grigorios Nikitidis

AstraZeneca

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Håkan Bladh

AstraZeneca

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Edward Jolyon Griffen

AstraZeneca

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Jean-Claude Arnould

AstraZeneca

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John Peter Bailey

AstraZeneca

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Karolina Lawitz

AstraZeneca

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Malena Bengtsson

AstraZeneca

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Peter Storm

AstraZeneca

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Thomas Geoffrey Colerick Bird

AstraZeneca

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Tomas Klingstedt

AstraZeneca

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