Jeannette E. Brown

Anticoccidial riboflavine antagonists.

4 types of riboflavine antagonists have broad-spectrum activity in poultry coccidiosis. 5-Deazariboflavine is most effective. 10-Benzyl analogs of riboflavine control intestinal species of coccidia.

Structure-activity relationships of the non-peptidyl growth hormone secretagogue L-692,429

Abstract Systematic investigation of the amino acid sidechain of L-692,429, the prototype of a novel class of benzolactam growth hormone (GH) secretagogues, has led to the preparation of L-692,585, a 2(R)-hydroxypropyl amino analog, which is twenty times more potent in vitro than L-692,429. Additional amino modifications reported here further define the structure-activity profile for L-692,429.

Aliphatic replacements of the biphenyl moiety of the nonpeptidyl growth hormone secretagogues L-692,429 and L-692,585

Abstract Replacement of the central phenyl ring of the biphenyl moiety in the novel growth hormone (GH) secretagogues L-692,429 and L-692,585 with partially or completely saturated surrogates has been investigated. The cyclohexenyl analogue 37 displayed GH releasing activity comparable to L-692,585, indicating that the aromaticity of this central ring is not critical for bioactivity and that this ring may serve primarily to orient the benzolactam and phenyltetrazole pharmacophores.