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Archives of Dermatological Research | 2006

Anti-inflammatory efficacy of licochalcone a : correlation of clinical potency and in vitro effects

Ludger Kolbe; Jeannine Immeyer; Jan Batzer; Ursula Wensorra; Karen Torn Dieck; Claudia Mundt; Rainer Wolber; Franz Stäb; Uwe Dr. Schönrock; Roger I. Ceilley; Horst Wenck

Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, has recently been reported to have anti-inflammatory as well as anti-microbial effects. These anti-inflammatory properties might be exploited for topical applications of LicA. We conducted prospective randomized vehicle-controlled clinical trials to assess the anti-irritative efficacy of cosmetic formulations containing LicA in a post-shaving skin irritation model and on UV-induced erythema formation. The clinical trials were accompanied by a series of in vitro experiments to characterize anti-inflammatory properties of LicA on several dermatologically relevant cell types. Topical LicA causes a highly significant reduction in erythema relative to the vehicle control in both the shave- and UV-induced erythema tests, demonstrating the anti-irritative properties of LicA. Furthermore, LicA is a potent inhibitor of pro-inflammatory in vitro responses, including N-formyl-MET-LEU-PHE (fMLP)- or zymosan-induced oxidative burst of granulocytes, UVB-induced PGE2 release by keratinocytes, lipopolysaccharide (LPS)-induced PGE2 release by adult dermal fibroblasts, fMLP-induced LTB4 release by granulocytes, and LPS-induced IL-6/TNF-α secretion by monocyte-derived dendritic cells. The reported data suggest therapeutic skin care benefits from LicA when applied to sensitive or irritated skin.


Archive | 2001

Cosmetic or dermatological compositions useful for treating inflammatory skin conditions and dry skin comprise a Pongamia pinnata extract

Christopher Mummert; Claudia Mundt; Thomas Blatt; Ludger Kolbe; Jeannine Immeyer; Uwe Schoenrock; Timo Rode; Franz Staeb


Archive | 2005

Topical use of bis-arylimidazo[1,2-a]thiolane derivatives

Ludger Kolbe; Uwe Pfannenbecker; Inge Kruse; Tobias Sokolowski; Jeannine Immeyer; Karen Tom Dieck; Gerd Dannhardt


Archive | 2011

Use of honokiol and magnolol or Magnolia bark extract containing honokiol and magnolol, for the preparation of topical formulation to increase microcirculation of skin and/or angiogenic effect of topical preparation

Gitta Neufang; Nils Peters; Torsten Schläger; Ludger Kolbe; Jeannine Immeyer; Julia Eckert; Thomas Raschke


Archive | 2011

Verwendung von 4-n Butylresorcin zur Herstellung einer kosmetischen oder dermatologischen Zubereitung zur Prophylaxe oder Behandlung von Augenringen die durch eine gestörte Durchblutung der Haut im Augenbereich hervorgerufen werden

Gitta Neufang; Ludger Kolbe; Cathrin Scherner; Jeannine Immeyer


Archive | 2006

Cosmetic formulations for improving the appearance of the skin

Thomas Raschke; Christopher Mummert; Ludger Kolbe; Jeannine Immeyer; Julia Eckert; Gitta Neufang


Archive | 2003

Use of honeysuckle extracts for producing cosmetic or dermatological preparations for the prophylaxis and treatment of inflammatory skin conditions and/or for protecting sensitive skin

Stefan Gallinat; Jeannine Immeyer; Ludger Kolbe; Christopher Mummert; Claudia Mundt; Uwe Schoenrock; Kirsten Venzke


Archive | 2011

USE OF 4-N-BUTYLRESORCINOL TO PRODUCE A COSMETIC OR DERMATOLOGICAL PREPARATION FOR PREVENTING OR TREATING UNDER-EYE CIRCLES THAT ARE CAUSED BY DISRUPTED BLOOD FLOW THROUGH THE SKIN IN THE EYE AREA

Ludger Kolbe; Gitta Neufang; Jeannine Immeyer; Cathrin Scherner


Archive | 2010

Kosmetische Zubereitung mit einem Gehalt an Magnolienrindenextrakt zur Steigerung der Mikrozirkulation der haut sowie die Verwendung von Magolienrindenextrakt zur Herstellung topischer Zubereitungen zur Steigerung der Mikrozirkulation der Haut und/oder angiogenetisch wirksamer topischer Zubereitungen

Julia Eckert; Jeannine Immeyer; Kolbe Ludger; Neufang Gitta; Peters Nils; Thomas Raschke; Schläger Torsten


Archive | 2009

Verwendung von 4-n Butylresorcin zur Herstellung einer kosmetischen oder dermatologischen Zubereitung zur Prophylaxe oder Behandlung von Augenringen die durch eine gestörte Durchblutung der Haut im Augenbereich hervorgerufen werden Use caused by an impaired blood supply to the skin around the eyes of 4-n butylresorcinol for the preparation of a cosmetic or dermatological preparation for the prophylaxis or treatment of dark circles

Jeannine Immeyer; Ludger Kolbe; Gitta Neufang; Cathrin Scherner

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