Jee-Ho Choi

Cutaneous side effects in non-small cell lung cancer patients treated with Iressa (ZD1839), an inhibitor of epidermal growth factor.

We report the cutaneous side effects of Iressa (ZD1839), a new anti-cancer agent that acts by inhibiting epidermal growth factor receptor signal transduction. The most common cutaneous adverse effect was the development of an acneiform eruption on the face, anterior trunk and back (39%). The second most common side effect was xerosis or desquamation of the face, body or distal parts of the fingers or toes (36%). Additional cutaneous side effects included multiple ingrown paronychial inflammation of the toes and fingers (6%), small ulcers of the oral mucosa or nasal mucosa, and urticaria. The cutaneous adverse effects of Iressa are similar to those of other epidermal growth factor receptor-targeted agents and result from direct interference with the functions of epidermal growth factor receptor signalling in the skin. Iressa-induced acne may be related to excessive follicular hyperkeratosis, follicular plugging, obstructions of the follicular ostium and alteration of hair cycle progression, which lead to an inflammatory response. Xerosis or desquamation reflects a disturbance of the equilibrium between proliferation and differentiation of epidermis. The mechanism by which Iressa leads to the development of paronychia and ingrown nail remains unclear.

Primary adenoid cystic carcinoma of skin with lung metastasis

Primary cutaneous adenoid cystic carcinoma was first reported in 1975. We report a case of this malignancy with pulmonary metastases in a 70-year-old man and offer a brief review of the literature.

Polymerase chain reaction (PCR) for human herpesvirus 8 and heteroduplex PCR for clonality assessment in angiolymphoid hyperplasia with eosinophilia and Kimura’s disease

Background: Recently, human herpesvirus 8 (HHV‐8) has been isolated from almost all cases of Kaposi’s sarcoma. It has not been found in most cutaneous hemangioproliferative disorders other than Kaposi’s sarcoma. Benign vascular lesions including Kimura’s disease were not found to contain the HHV‐8 DNA sequence. However, there has been contradictory data concerning the presence of HHV‐8 in angiolymphoid hyperplasia with eosinophilia (ALHE). Clonality studies in ALHE and Kimura’s disease were rare.

Clinical and pathological characteristics of extradigital and digital glomus tumours: a retrospective comparative study.

Background  Most glomus tumours are located in the digits, especially in subungual areas. Less is known, however, about the clinical characteristics of extradigital glomus tumours.

Clinical and Histologic Features of 64 Cases of Steatocystoma Multiplex

Steatocystoma multiplex (SM) shares many clinical features and may show overlapping histopathological features with eruptive vellus hair cyst (EVHC). Clinical data and pathologic features of 64 patients with SM were evaluated in detail. Most of the cases were sporadic, with an average onset age of 26 years and distribution on the arms, chest, axillae, and neck. All cases exhibited eosinophilic cuticle and lack of granular layer, and 17–42% displayed vellus hair, hair follicles, keratin, and smooth muscle components within the cavity, in the wall, or adjacent to it. The results of this study add further evidence to the hypothesis that SM is a hamartomatous condition and that SM and EVHC are variants of one disorder which originates in the pilosebaceous duct.

Successful removal of freckles in Asian skin with a Q-switched alexandrite laser.

Background. Although freckles are light‐brown macules most frequently observed in individuals with red or blond hair and blue or gray eyes, freckles are common to Asian people, including Koreans. Treatment may be requested on cosmetic grounds. Objective. The objective of this study was to determine the effectiveness of the Q‐switched alexandrite laser (wavelength 755 nm; pulse width 100 nsec) in treating the 197 cases of Asian skin with freckles and to observe any side effects such as pigmentary changes or scarring. Methods. One hundred ninety‐seven patients with freckles were treated with the Q‐switched alexandrite laser at 8‐week intervals and clinically analyzed. Results. More than 76% removal of freckles required an average of 1.5 treatment sessions with 7.0 J/cm2. No scarring, long‐standing pigmentary changes, or textural changes were seen in laser‐irradiated skin. Conclusion. The Q‐switched alexandrite laser is a safe and highly effective modality for removing freckles without scarring or permanent pigmentary changes in Asian skin.

Linear cutaneous lupus erythematosus in the lines of Blaschko.

Abstract:  Eleven patients with linear cutaneous lupus erythematosus following the lines of Blaschko have been previously reported in the literature. We describe a child with this entity following Blaschko lines on the trunk. The patient responded to oral hydroxychloroquine therapy combined with topical flurandrenolide tape resulting in resolution with atrophic scarring. The clinical and histological features of linear cutaneous lupus erythematosus are discussed and a review of the literature is presented.The lines of Blaschko describe distribution patterns which may represent embryologic developmental pathways. This distribution may occasionally be followed by some congenital and acquired skin disorders. We describe a child with linear cutaneous lupus erythematosus (LCLE) following Blaschko lines on the face.

Tinea pedis in Korean children

Background Tinea pedis is an infrequent disease in children before the age of puberty. There are few epidemiologic and clinical data regarding cases of tinea pedis observed in children.

Onychomycosis and Trichosporon beigelii in Korea

Background Onychomycosis is a common superficial fungal infection. Causative organisms in onychomycosis have been extensively studied, but the role of nondermatophytes is controversial. Trichosporon beigelii is a soil and water inhabiting yeast and is occasionally found in the flora normally associated with human skin, mouth, and nails. Several reports in the literature have suggested that T. beigelii is one of the pathogens in onychomycosis.

Two cases of angiomyxolipoma (vascular myxolipoma) of subcutaneous tissue

Abstract:  Angiomyxolipoma (vascular myxolipoma) is a recently described rare variant of lipoma, four cases of which have been reported to date. Microscopically, the lesion consists of adipose tissue without lipoblasts, extensive myxoid areas, and numerous blood vessels. The main differential diagnosis of this lesion is myxoid liposarcoma, and other adipocytic lesions such as myxolipoma, myxoid spindle cell lipoma should be included. We report two cases of angiomyxolipoma located in the subcutaneous tissue of the forearm and the wrist.