Mi-Woo Lee

Cutaneous adverse effects in patients treated with the multitargeted kinase inhibitors sorafenib and sunitinib

Summary Background  The multitargeted kinase inhibitors sorafenib and sunitinib have improved treatment of solid tumours including renal cell carcinoma and hepatocellular carcinoma by offering better clinical responses. However, sorafenib and sunitinib are commonly associated with cutaneous toxicity.

CD30‐positive T‐cell‐rich pseudolymphoma induced by gold acupuncture

Summary Cases of pseudolymphoma induced by intradermal gold injection or gold piercing have previously been described. Most of these cases showed the histopathological finding of B‐lymphocyte predominant lymphocytoma cutis. We describe a patient with gold acupuncture‐induced T‐cell‐rich pseudolymphoma. Some T cells showed positive staining with CD30. The lesions responded to an intralesional injection of triamcinolone acetonide.

Characteristics of cutaneous lymphomas in Korea.

The clinicopathologic characteristics of malignant lymphomas vary according to geography. The aim of this study was to determine the relative frequency of cutaneous lymphomas and to examine the clinical relevance of the WHO classification in Korean cases of cutaneous lymphoma. The Korean Dermatopathology Research Group conducted a clinicopathologic review of a nationwide collection of 80 cutaneous lymphomas, diagnosed at 23 institutes over a recent 3‐year period. The clinical records, haematoxylin & eosin‐stained slides and immunohistochemical stains from 80 patients with malignant lymphomas of the skin were reviewed. In our study, the most frequent cutaneous lymphoma was mycosis fungoides. Compared with Western countries, Korea had higher rates of NK/T cell lymphoma and subcutaneous panniculitis‐like T‐cell lymphoma and a much lower rate of B‐cell lymphoma. The occurrence rates for various subtypes of malignant lymphoma in Korea are distinct from those in Western countries. The EORTC classification is not fully appropriate in dealing with Korean cases of cutaneous lymphoma, because NK/T cell lymphoma is not included in the EORTC classification for cutaneous lymphoma.

Linear cutaneous lupus erythematosus in the lines of Blaschko.

Abstract:  Eleven patients with linear cutaneous lupus erythematosus following the lines of Blaschko have been previously reported in the literature. We describe a child with this entity following Blaschko lines on the trunk. The patient responded to oral hydroxychloroquine therapy combined with topical flurandrenolide tape resulting in resolution with atrophic scarring. The clinical and histological features of linear cutaneous lupus erythematosus are discussed and a review of the literature is presented.The lines of Blaschko describe distribution patterns which may represent embryologic developmental pathways. This distribution may occasionally be followed by some congenital and acquired skin disorders. We describe a child with linear cutaneous lupus erythematosus (LCLE) following Blaschko lines on the face.

Two cases of angiomyxolipoma (vascular myxolipoma) of subcutaneous tissue

Abstract:  Angiomyxolipoma (vascular myxolipoma) is a recently described rare variant of lipoma, four cases of which have been reported to date. Microscopically, the lesion consists of adipose tissue without lipoblasts, extensive myxoid areas, and numerous blood vessels. The main differential diagnosis of this lesion is myxoid liposarcoma, and other adipocytic lesions such as myxolipoma, myxoid spindle cell lipoma should be included. We report two cases of angiomyxolipoma located in the subcutaneous tissue of the forearm and the wrist.

Pseudomelanoma following laser therapy.

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A case of tinea manuum caused by Trichophyton mentagrophytes var. erinacei: the first isolation in Korea.

Hedgehogs have recently become popular exotic pets in Korea. Several diseases may be acquired from these animals including dermatophytosis, Salmonella infections, contact urticaria and possibly Mycobacterium infections. We describe here a 15‐year‐old girl who developed tinea manuum after keeping a hedgehog for 4 months. Diagnosis was confirmed by histopathologic and mycological examination. The causative agent was identified as Trichophyton mentagrophytes var. erinacei, a zoophilic dermatophyte.

Linear basaloid follicular hamartoma on the Blaschko's line of the face

We report a 5‐year‐old girl with localized basaloid follicular hamartoma. The lesion consisted of a linear, hypopigmented, atrophic patch on the right lateral side of nose. Of great interest is that the linear distribution of lesion may follow the Blaschkos line of the face.

Combination treatment of low-fluence 1,064-nm Q-switched Nd: YAG laser with novel intense pulse light in Korean melasma patients: a prospective, randomized, controlled trial.

BACKGROUND Recently, intense pulsed light (IPL) and low-fluence Q-switched neodymium-doped yttrium aluminum (LF-QS-Nd:YAG) laser have been successfully used to treat melasma. OBJECTIVE To evaluate the effectiveness and safety of combined novel fractionated IPL (IPL-F) with LF-QS-Nd:YAG laser in patients with melasma. METHODS Twelve patients underwent 6 treatment sessions of concomitant IPL-F and LF-QS-Nd:YAG laser (combination group), and 12 patients underwent 6 treatment session of IPL-F alone (IPL only group). Partial melasma area and severity index (MASI) scores were evaluated by 2 dermatologists using digital photography. RESULTS In the combination group, the partial MASI score has significantly decreased by 47% at 1 month after the treatment (p < .05) and 50% at 2 months after the last treatment (p < .01). At 1 month and 2 months after the treatment, the decrease in the partial MASI score of the combination group was significantly larger than that of the IPL only group (p < .05). In both groups, treatment with IPL-F and LF-QS-Nd:YAG laser was well tolerated. CONCLUSION Our results suggest that the combination of the IPL-F with LF-QS-Nd:YAG laser may be an effective and safe modality for melasma patients.

Hyperkeratosis of the nipple and areola as a sign of malignant acanthosis nigricans

A 34-year-old woman presented with a 2-year history of generalized hyperpigmented, verrucous cutaneous thickening and a 9-month history of hyperkeratotic lesions over her nipples and areolae. Two years previously, she had experienced recurrent epigastric soreness and cutaneous truncal thickening, especially in the axillae. Diagnostic investigation at that time revealed a poorly differentiated gastric adenocarcinoma with multiple lymph-node metastases. Distal gastrectomy and nine courses of monthly chemotherapy were performed, and the patient experienced significant improvement of her skin lesions. She was then lost to follow-up, until she returned to the oncology department for generalized weakness, abdominal pain and orthopnoea. She was subsequently referred to us because of worsening of her cutaneous conditions, which she reported had recurred approximately 9 months previously, including involvement of her nipples and areolae. Physical examination revealed hyperkeratotic thickening with brownish hyperpigmentation on the nipples and areolae (Fig. 1a), an almost generalized hyperpigmented velvety thickening of the skin, most pronounced in the axillae, neck, groin and perineum, papillomatous lesions on her eyelids and perioral area, and tylosis with pachydermatoglyphy (Fig. 1b). Skin biopsies from axilla and areola showed hyperkeratosis and epidermal papillomatosis; acanthosis was more prominent in the areolar lesion (Fig. 2a, b). The patient was diagnosed with malignant