Jeffrey L. Hesler

THz-Spectroscopy of Biological Molecules.

The terahertz frequency absorption spectraof DNA molecules reflect low-frequencyinternal helical vibrations involvingrigidly bound subgroups that are connectedby the weakest bonds, including thehydrogen bonds of the DNA base pairs,and/or non-bonded interactions. Althoughnumerous difficulties make the directidentification of terahertz phonon modes inbiological materials very challenging, ourresearch has shown that such measurementsare both possible and fruitful. Spectra ofdifferent DNA samples reveal a large numberof modes and a reasonable level ofsequence-specific uniqueness. In an attemptto show that the long wavelength absorptionfeatures are intrinsic properties ofbiological materials determined by phononmodes, a normal mode analysis has been usedto predict the absorption spectra ofpolynucleotide RNA Poly[G]-Poly[C]. Directcomparison demonstrated a correlationbetween calculated and experimentallyobserved spectra of the RNA polymers, thusconfirming that the fundamental physicalnature of the observed resonance structureis caused by the internal vibration modesin the macromolecules.In this work we demonstrate results fromFourier-Transform Infrared (FTIR)spectroscopy of DNA macromolecules andrelated biological materials in theterahertz frequency range. Carefulattention was paid to the possibility ofinterference or etalon effects in thesamples, and phenomena were clearlydifferentiated from the actual phononmodes. In addition, we studied thedependence of transmission spectra ofaligned DNA and polynucleotide film sampleson molecule orientation relative to theelectromagnetic field, showing the expectedchange in mode strength as a function ofsample orientation. Further, the absorptioncharacteristics were extracted from thetransmission data using the interferencespectroscopy technique, and a stronganisotropy of terahertz characteristics wasdemonstrated.

Terahertz detector utilizing two-dimensional electronic fluid

We report on the first implementation of a terahertz detector utilizing two-dimensional (2-D) electronic fluid in a high electron mobility transistor (HEMT) operating at 2.5 THz. The terahertz radiation induced a dc drain-to-source voltage proportional to the radiation intensity. The measured dependencies of the detector responsivity on the gate bias are in good agreement with the gate bias dependence of the normalized responsivity predicted by the detector theory. This result shows the potential for developing a new family of electronics devices-plasma wave electronics devices-operating at terahertz frequencies.

A Broadband Quasi-Optical Terahertz Detector Utilizing a Zero Bias Schottky Diode

A quasi-optical broadband terahertz detector using a zero bias Schottky diode mounted on a self-complimentary sinuous antenna has been developed. Design and characterization of this detector are described. Measurements show that a responsivity of 300-1000 V/W covering the frequency range of 150-440 GHz has been achieved. The detector performance has been compared to waveguide detectors covering four frequency bands up to 600 GHz. A recent measurement at 600-900 GHz yielded the same output voltage as a waveguide detector. The noise equivalent power level of this detector is estimated to be 5-20 pW/√(Hz) based on the measurements of similar detectors.

Resonant metal-mesh bandpass filters for the far infrared

The spectral performance of freestanding resonant metal-mesh bandpass filters operating with center frequencies ranging from 585 GHz to 2.1 THz is presented. These filters are made up of a 12-µm-thick copper film with an array of cross-shaped apertures that fill a circular area with a 50-mm diameter. The filters exhibit power transmission in the range 97-100% at their respective center frequencies and stop-band rejection in excess of 18 dB. The theoretically predicted nondiffracting properties of the meshes are experimentally verified through high-resolution beam mapping. Scalability of the filter spectra with mesh dimensions is demonstrated over a wide spectral range. Several modeling methods are considered, and results from the models are shown.

Fixed-tuned submillimeter wavelength waveguide mixers using planar Schottky-barrier diodes

The design, construction, and evaluation of fixed-tuned submillimeter wavelength waveguide mixers using planar Schottky diodes are presented in this paper. Electromagnetic fields within the planar diode package were analyzed using the finite-element method (FEM). Mixers using the University of Virginia SCIT5 planar diode were designed at both 585 and 690 GHz. A double sideband (DSB) system noise temperature of 2380 K was measured at 585 GHz using 1.16 mW of local oscillator (LO) power, and a system noise temperature of 2970 K DSB was measured at 690 GHz using 1.04 mW of LO power. In addition, the 585 GHz mixer was cooled to both 77 K and 4.2 K, with measured system noise temperatures of 1240 and 880-K DSB using LO powers of 0.47 and 0.14 mW, respectively. The modeling techniques were found to predict the measured conversion loss to within 1 dB. The performance of planar diode mixers is now within a factor of 1.5 of the best whisker-contacted Schottky diode mixers in this frequency range.

Terahertz Fourier transform characterization of biological materials in a liquid phase

Significant progress has been achieved during the last several years relating to experimental and theoretical aspects of terahertz (or submillimetre wave) Fourier transform spectroscopy of biological macromolecules. However, previous research in this spectral range has been focused on bio-materials in solid state since it was common opinion that high water absorption will obscure the spectral signatures of the bio-molecules in solutions. At the same time, the biological functions of DNA and proteins take place in water solutions. In this work, the spectra of DNA samples have been measured in liquid phase (gel) over the spectral range 10–25 cm−1 and compared with spectra obtained from solid films. The results demonstrate that there is very little interference between the spectral features of the material under test and the water background except for the band around 18.6 cm−1. Multiple resonances due to low frequency vibrational modes within biological macromolecules in solutions are unambiguously demonstrated. Higher level of sensitivity and higher sharpness of vibrational modes are observed in the liquid environment in comparison with the solid phase, with the width of spectral lines 0.3–0.5 cm−1. Gel sample spectra are found to be polarization-dependent. The ability of THz spectroscopy to characterize samples in liquid phase could be very important since it permits examination of DNA interactions in real (wet) samples. One demonstrated example of practical importance is the ability to discriminate between spectral patterns for native and denaturated DNA.

Terahertz sources and detectors and their application to biological sensing

Terahertz spectroscopy has long been used as an important measurement tool in fields such as radio astronomy, physical chemistry, atmospheric studies and plasma research. More recently terahertz technology has been used to develop an exciting new technique to investigate the properties of a wide range of biological materials. Although much research remains before a full understanding of the interaction between biomaterials and terahertz radiation is developed, these initial studies have created a compelling case for further scientific study. Also, the potential development of practical tools to detect and identify biological materials such as biological–warfare agents and food contaminants, or of medical diagnostic tools, is driving the need for improved terahertz technology. In particular, improved terahertz sources and detectors that can be used in practical spectroscopy systems are needed. This paper overviews some of the recent measurements of the terahertz spectra of biomaterials and the ongoing efforts to create an all–solid–state technology suitable not only for improved scientific experiments but also for military and commercial applications.

Integrated GaAs Schottky mixers by spin-on-dielectric wafer bonding

A novel wafer bonding process has been used to integrate high quality GaAs devices on quartz substrates. The method of adhesion by spin-on-dielectric temperature enhanced reflow (MASTER) uses a spin-on-dielectric as a bonding agent to achieve a robust bond that in no way degrades either high frequency performance or reliability. A 585 GHz integrated mixer fabricated using this process has achieved record double-sideband mixer noise temperatures of 1,150 K at room temperature and 880 K at 77 K. Furthermore, the integrated mixers require no mechanical tuning, are easy to assemble, and repeatable. Precise control of the circuit geometry, coupled with the reduction of parasitic elements, allows greater accuracy of computer simulations and will therefore lead to better high frequency performance and bandwidth. This new technology is easily extended to other circuit designs and will allow the development of a new generation of submillimeter-wave integrated circuits.

Submillimeter-wave Fourier transform spectroscopy of biological macromolecules

In this article we report experimental results on Fourier-transform infrared spectroscopy of deoxyribonucleic acid (DNA) macromolecules and related biological materials in the submillimeter range (i.e., ∼10–500 cm−1). Film samples made from commercial DNA fibers, polyadenylic acid potassium salt, and cellular agents such as the spore form of Bacillus subtillis have been prepared and measured. A broad series of measurements carried out in the low frequency region (10–50 cm−1) with a higher resolution of 0.2 cm−1 revealed fine features—multiple dielectric resonances in the submillimeter-wave spectra obtained from DNA samples. These long-wave absorption features are shown to be intrinsic properties of biological materials determined by phonon modes. The emphasis is on reproducibility of experimental spectra and on receiving reliable results. The effects of differences in sample preparation, including sample geometry, orientation, and aging are studied and separated from the phonon effects that determine the ...

A 5 mW and 5% efficiency 210 GHz InP-based heterostructure barrier varactor quintupler

This letter reviews the design, construction, and measurement of a 210 GHz heterostructure barrier varactor frequency quintupler. The quintupler utilizes planar heterostructure barrier varactors (HBVs) based on the InGaAs/InAlAs/AlAs material system and has produced a measured output power of 5.2 mW with 5.2% conversion efficiency at 210 GHz. This performance is comparable to the state-of-the-art results reported in the literature for HBV frequency triplers operating at millimeter and submillimeter wavelengths.