Thomas W. Crowe

THz-Spectroscopy of Biological Molecules.

The terahertz frequency absorption spectraof DNA molecules reflect low-frequencyinternal helical vibrations involvingrigidly bound subgroups that are connectedby the weakest bonds, including thehydrogen bonds of the DNA base pairs,and/or non-bonded interactions. Althoughnumerous difficulties make the directidentification of terahertz phonon modes inbiological materials very challenging, ourresearch has shown that such measurementsare both possible and fruitful. Spectra ofdifferent DNA samples reveal a large numberof modes and a reasonable level ofsequence-specific uniqueness. In an attemptto show that the long wavelength absorptionfeatures are intrinsic properties ofbiological materials determined by phononmodes, a normal mode analysis has been usedto predict the absorption spectra ofpolynucleotide RNA Poly[G]-Poly[C]. Directcomparison demonstrated a correlationbetween calculated and experimentallyobserved spectra of the RNA polymers, thusconfirming that the fundamental physicalnature of the observed resonance structureis caused by the internal vibration modesin the macromolecules.In this work we demonstrate results fromFourier-Transform Infrared (FTIR)spectroscopy of DNA macromolecules andrelated biological materials in theterahertz frequency range. Carefulattention was paid to the possibility ofinterference or etalon effects in thesamples, and phenomena were clearlydifferentiated from the actual phononmodes. In addition, we studied thedependence of transmission spectra ofaligned DNA and polynucleotide film sampleson molecule orientation relative to theelectromagnetic field, showing the expectedchange in mode strength as a function ofsample orientation. Further, the absorptioncharacteristics were extracted from thetransmission data using the interferencespectroscopy technique, and a stronganisotropy of terahertz characteristics wasdemonstrated.

GaAs Schottky diodes for THz mixing applications

The operation of GaAs Schottky barrier diodes, the critical mixer element used in heterodyne receivers for a variety of scientific applications in the terahertz frequency range, is reviewed. The constraints that the receiver system places on the diodes are considered, and the fundamental guidelines for device optimization are presented. The status of ongoing research, both experimental and theoretical, is examined. Emphasis is placed on investigations of the various effects that can limit diode performance at these high frequencies. Investigations of planar diode technology are summarized, and the potential replacement of whisker-contacted devices with planar structures is considered. >

A Novel Whiskerless Schottky Diode for Millimeter and Submillimeter Wave Application

A novel whiskerless Schottky diode has been developed in which shunt capacitance is minimized by means of an etched surface channel. This structure is easily fabricated and the DC I-V characteristics areas good as those of the best available whisker-contacted devices. Preliminary RF characterization in an unoptimized mount at 110 GHz has yielded room temperature SSB mixer noise temperature of 950 K and SSB conversion loss of 6.4 dB. The diode is robust and can be operated at cryogenic temperatures. Potential applications include waveguide and planar mixers, planar arrays, multipliers, varactor tuners, and microwave integrated circuits.

Resonant metal-mesh bandpass filters for the far infrared

The spectral performance of freestanding resonant metal-mesh bandpass filters operating with center frequencies ranging from 585 GHz to 2.1 THz is presented. These filters are made up of a 12-µm-thick copper film with an array of cross-shaped apertures that fill a circular area with a 50-mm diameter. The filters exhibit power transmission in the range 97-100% at their respective center frequencies and stop-band rejection in excess of 18 dB. The theoretically predicted nondiffracting properties of the meshes are experimentally verified through high-resolution beam mapping. Scalability of the filter spectra with mesh dimensions is demonstrated over a wide spectral range. Several modeling methods are considered, and results from the models are shown.

A high-power fixed-tuned millimeter-wave balanced frequency doubler

We report on the design and evaluation of a 40-80-GHz (40/80-GHz) high-power wide-band fixed-tuned balanced doubler. The active device is a single GaAs chip comprising a linear array of six planar Schottky varactors. The varactors and a quartz microstrip circuit are embedded in a split waveguide block. We have achieved a measured 3-dB fixed-tuned bandwidth of 17% and measured flange-to-flange peak efficiency of 48% at an input-power level of 200 mW. The doubler operates at near-peak efficiency (45%) at an input power of 250 mW. We have cooled the block to 14 K and achieved an efficiency of 61% at an input-power level of 175 mW and an efficiency of 48% at an input-power level of 365 mW. Emphasis has been placed on making the design easy to fabricate and scalable to higher frequencies.

Terahertz Fourier transform characterization of biological materials in a liquid phase

Significant progress has been achieved during the last several years relating to experimental and theoretical aspects of terahertz (or submillimetre wave) Fourier transform spectroscopy of biological macromolecules. However, previous research in this spectral range has been focused on bio-materials in solid state since it was common opinion that high water absorption will obscure the spectral signatures of the bio-molecules in solutions. At the same time, the biological functions of DNA and proteins take place in water solutions. In this work, the spectra of DNA samples have been measured in liquid phase (gel) over the spectral range 10–25 cm−1 and compared with spectra obtained from solid films. The results demonstrate that there is very little interference between the spectral features of the material under test and the water background except for the band around 18.6 cm−1. Multiple resonances due to low frequency vibrational modes within biological macromolecules in solutions are unambiguously demonstrated. Higher level of sensitivity and higher sharpness of vibrational modes are observed in the liquid environment in comparison with the solid phase, with the width of spectral lines 0.3–0.5 cm−1. Gel sample spectra are found to be polarization-dependent. The ability of THz spectroscopy to characterize samples in liquid phase could be very important since it permits examination of DNA interactions in real (wet) samples. One demonstrated example of practical importance is the ability to discriminate between spectral patterns for native and denaturated DNA.

Terahertz sources and detectors and their application to biological sensing

Terahertz spectroscopy has long been used as an important measurement tool in fields such as radio astronomy, physical chemistry, atmospheric studies and plasma research. More recently terahertz technology has been used to develop an exciting new technique to investigate the properties of a wide range of biological materials. Although much research remains before a full understanding of the interaction between biomaterials and terahertz radiation is developed, these initial studies have created a compelling case for further scientific study. Also, the potential development of practical tools to detect and identify biological materials such as biological–warfare agents and food contaminants, or of medical diagnostic tools, is driving the need for improved terahertz technology. In particular, improved terahertz sources and detectors that can be used in practical spectroscopy systems are needed. This paper overviews some of the recent measurements of the terahertz spectra of biomaterials and the ongoing efforts to create an all–solid–state technology suitable not only for improved scientific experiments but also for military and commercial applications.

GaAs Schottky Barrier mixer diodes for the frequency range 1-10 THz

Recent technological advances have made possible the development of heterodyne receivers with high sensitivity and high spectral resolution for frequencies up to 3,000 GHz (3 THz). These receivers rely on GaAs Schottky barrier mixer diodes to translate the high-frequency signal to a lower frequency where amplification and signal processing are possible. In the frequency range from 1–10 THz several new effects will limit diode performance. These effects are discussed and guidelines for diode design are presented.

A novel Schottky/2-DEG diode for millimeter- and submillimeter-wave multiplier applications

A high-frequency diode is proposed for use as a frequency multiplier element in the millimeter- and submillimeter-wavelength regions. The Schottky/2-DEG diode utilizes a Schottky contact along the edge of a two-dimensional electron gas (2-DEG) structure. This geometry allows one to combine a very low series resistance due to the excellent transport properties of the 2-DEG with a high breakdown voltage caused by the 2-D electric field spreading in the depletion region (compared to a 1-D field variation in the conventional Schottky diode). The higher Fermi velocity of the 2-DEG leads to a less severe transit-time limitation of the frequency response.<<ETX>>

A micron-thickness, planar Schottky diode chip for terahertz applications with theoretical minimum parasitic capacitance

The design and fabrication of a novel planar Schottky diode with greatly reduced shunt capacitance for millimeter- and submillimeter-wave applications is described. The dominant pad-to-pad shunt capacitance is minimized by replacing the substrate GaAs with a low-dielectric substitute. This replacement substrate can be easily removed by the user after the device is soldered into the mixer circuit. This will yield the minimum possible pad-to-pad shunt capacitance.<<ETX>>