Jennifer Gunn

Influenza and public health: learning from past pandemics.

Foreword. Introduction 1. Globalized Complexity and the Microbial Traffic of New and Emerging Infectious Disease Threats Part 1. Reframing 1918: States, Pandemics, and Public Health 2. Barcelonas Influenza: A Comparison of the 1889-1890 and 1918 Autumn Outbreaks 3. Prevent or Heal, Laisser Faire or Coerce: The Public Health Politics of Influenza in France, 1918-1919 Uses and Misuses of the History of the 1918 Pandemic: Two Integrative Essays Part 2. Epidemiology, Virology, and 20th Century Epidemics 4. Are Influenzas in Southern China Byproducts of its Globalizing Historical Present? 5. Recent Influenza Epidemics and Implications for Contemporary Influenza Research 6. Influenza and the Remaking of Epidemiology, 1918-1960 7.Hong Kong Flu (1968) Revisited 40 Years Later Scientific Influenza Research and the Management of Uncertainty: Contemporary Perspectives Part 3. Governmental and Non-Governmental Institutions and the Politics of Epidemic Management 8. Mobility Restrictions, Isolation, and Quarantine: Historical Perspective on Contemporary Debates 9 .Influenza, Intellectual Property, and Knowledge Sharing: A Recent History 10. Biosecurity in Time of Avian Influenza: Vietnam Epidemics and Ethics: Comparative Insights and Critical Questions for Public Health Planning. Commentaries. Conclusion

Longitudinal Analysis of Serological Responses of Adults to Helicobacter pylori Antigens

Because Helicobacter pylori persist for decades in the human stomach, the aim of this study was to examine the long-term course of H. pylori-specific serum immunoglobulin G (IgG) responses with respect to subclass and antigenic target. We studied paired serum samples obtained in 1973 and in 1994 in Vammala, Finland, from 64 healthy H. pylori-positive adults and from other healthy control subjects. H. pylori serum immunoglobulin A, IgG, and IgG subclass responses were determined by antigen-specific enzyme-linked immunosorbent assays. H. pylori-specific IgG1 and IgG4 subtype responses from 47 subjects were similar in 1973 and 1994, but not when compared with unrelated persons. H. pylori-specific IgG1:IgG4 ratios among the participants varied >1000-fold; however, 57 (89.1%) of 64 subjects had an IgG1:IgG4 ratio >1.0, consistent with a predominant IgG1 (Th1) response. Furthermore, ratios in individual hosts were stable over the 21-year period (r = 0.56; P < .001). The immune response to heat shock protein HspA was unchanged in 49 (77%) of the 64 subjects tested; of the 15 whose serostatus changed, all seroconverted and were significantly younger than those whose status did not change. These findings indicate that H. pylori-specific antibody responses are host-specific with IgG1:IgG4 ratios stable over 21 years, IgG1 responses predominating, and HspA seroconversion with aging.

Mobility restrictions, isolation and quarantine: Historical perspectives on contemporary debates

Foreword. Introduction 1. Globalized Complexity and the Microbial Traffic of New and Emerging Infectious Disease Threats Part 1. Reframing 1918: States, Pandemics, and Public Health 2. Barcelonas Influenza: A Comparison of the 1889-1890 and 1918 Autumn Outbreaks 3. Prevent or Heal, Laisser Faire or Coerce: The Public Health Politics of Influenza in France, 1918-1919 Uses and Misuses of the History of the 1918 Pandemic: Two Integrative Essays Part 2. Epidemiology, Virology, and 20th Century Epidemics 4. Are Influenzas in Southern China Byproducts of its Globalizing Historical Present? 5. Recent Influenza Epidemics and Implications for Contemporary Influenza Research 6. Influenza and the Remaking of Epidemiology, 1918-1960 7.Hong Kong Flu (1968) Revisited 40 Years Later Scientific Influenza Research and the Management of Uncertainty: Contemporary Perspectives Part 3. Governmental and Non-Governmental Institutions and the Politics of Epidemic Management 8. Mobility Restrictions, Isolation, and Quarantine: Historical Perspective on Contemporary Debates 9 .Influenza, Intellectual Property, and Knowledge Sharing: A Recent History 10. Biosecurity in Time of Avian Influenza: Vietnam Epidemics and Ethics: Comparative Insights and Critical Questions for Public Health Planning. Commentaries. Conclusion