Jens Ackerstaff
Bayer HealthCare Pharmaceuticals
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Publication
Featured researches published by Jens Ackerstaff.
Journal of Medicinal Chemistry | 2017
Markus Follmann; Jens Ackerstaff; Gorden Redlich; Frank Wunder; Dieter Lang; Armin Kern; Peter Fey; Nils Griebenow; Eva-Maria Becker-Pelster; Axel Kretschmer; Volker Geiss; Volkhart Min-Jian Li; Alexander Straub; Joachim Mittendorf; Rolf Jautelat; Hartmut Schirok; Karl-Heinz Schlemmer; Klemens Lustig; Michael Gerisch; Andreas Knorr; Hanna Tinel; Thomas Mondritzki; Hubert Trübel; Peter Sandner; Johannes-Peter Stasch
The first-in-class soluble guanylate cyclase (sGC) stimulator riociguat was recently introduced as a novel treatment option for pulmonary hypertension. Despite its outstanding pharmacological profile, application of riociguat in other cardiovascular indications is limited by its short half-life, necessitating a three times daily dosing regimen. In our efforts to further optimize the compound class, we have uncovered interesting structure-activity relationships and were able to decrease oxidative metabolism significantly. These studies resulting in the discovery of once daily sGC stimulator vericiguat (compound 24, BAY 1021189), currently in phase 3 trials for chronic heart failure, are now reported.
Archive | 2011
Markus Follmann; Johannes-Peter Stasch; Gorden Redlich; Jens Ackerstaff; Nils Griebenow; Andreas Knorr; Eva-Maria Becker; Frank Wunder; Volkhart Min-Jian Li; Elke Hartmann; Joachim Mittendorf; Karl-Heinz Schlemmer; Rolf Jautelat; Donald Bierer
Archive | 2011
Markus Follmann; Jens Ackerstaff
Archive | 2016
Ulrike Röhn; Manuel Ellermann; Julia Strassburger; Astrid Wendt; Susanne Röhrig; Robert Webster; Martina Victoria Schmidt; Adrian Tersteegen; Kristin Beyer; Martina Schäfer; Anja Buchmüller; Christoph Gerdes; Michael Sperzel; Steffen Sandmann; Stefan Heitmeier; Alexander Hillisch; Jens Ackerstaff; Carsten Terjung
Archive | 2013
Chantal Fürstner; Jens Ackerstaff; Alexander Straub; Heinrich Meier; Hanna Tinel; Katja Zimmermann; Adrian Tersteegen; Dimitry Zubov; Raimund Kast; Jens Schamberger; Martina Schäfer; Kirsten Börngen
Archive | 2016
Ulrike Röhn; Manuel Ellermann; Julia Strassburger; Astrid Wendt; Susanne Röhrig; Robert Webster; Martina Victoria Schmidt; Adrian Tersteegen; Kristin Beyer; Martina Schäfer; Anja Buchmüller; Christoph Gerdes; Michael Sperzel; Steffen Sandmann; Stefan Heitmeier; Alexander Hillisch; Jens Ackerstaff; Carsten Terjung
Archive | 2012
Markus Follmann; Johannes-Peter Stasch; Gorden Redlich; Alexander Straub; Jens Ackerstaff; Nils Griebenow; Andreas Knorr; Frank Wunder; Volkhart Min-Jian Li
Archive | 2015
Lars Bärfacker; Stefan Prechtl; Gerhard Siemeister; Antje Margret Wengner; Jens Ackerstaff; Katrin Nowak-Reppel; Benjamin Bader; Philip Lienau; Detlef Stöckigt
Archive | 2011
Jens Ackerstaff; Markus Follmann; Nils Griebenow; Rolf Jautelat; Andreas Knorr; Volkhart Min-Jian Li; Gorden Redlich; Hartmut Schirok; Johannes-Peter Stasch; Frank Wunder
Archive | 2011
Jens Ackerstaff; Markus Follmann; Nils Griebenow; Rolf Jautelat; Andreas Knorr; Volkhart Min-Jian Li; Gorden Redlich; Hartmut Schirok; Johannes-Peter Stasch; Frank Wunder
