Jens-Kerim Ergüden
Bayer
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Publication
Featured researches published by Jens-Kerim Ergüden.
ChemMedChem | 2018
Hartmut Beck; Mario Jeske; Kai Thede; Friederike Stoll; Ingo Flamme; Metin Akbaba; Jens-Kerim Ergüden; Gunter Karig; Jörg Keldenich; Felix Oehme; Hans-Christian Militzer; Ingo Hartung; Uwe Thuss
Small‐molecule inhibitors of hypoxia‐inducible factor prolyl hydroxylases (HIF‐PHs) are currently under clinical development as novel treatment options for chronic kidney disease (CKD) associated anemia. Inhibition of HIF‐PH mimics hypoxia and leads to increased erythropoietin (EPO) expression and subsequently increased erythropoiesis. Herein we describe the discovery, synthesis, structure–activity relationship (SAR), and proposed binding mode of novel 2,4‐diheteroaryl‐1,2‐dihydro‐3H‐pyrazol‐3‐ones as orally bioavailable HIF‐PH inhibitors for the treatment of anemia. High‐throughput screening of our corporate compound library identified BAY‐908 as a promising hit. The lead optimization program then resulted in the identification of molidustat (BAYu200585‐3934), a novel small‐molecule oral HIF‐PH inhibitor. Molidustat is currently being investigated in clinical phaseu2005III trials as molidustat sodium for the treatment of anemia in patients with CKD.
Archive | 2006
Ingo Flamme; Jens-Kerim Ergüden; Felix Oehme; Kai Thede; Gunter Karig; Alexander Kuhl; Hanno Wild; Joachim Schuhmacher; Peter Kolkhof; Lars Bärfacker; Joachim Hütter
Archive | 2007
Kai Thede; Ingo Flamme; Felix Oehme; Jens-Kerim Ergüden; Friederike Stoll; Joachim Schuhmacher; Hanno Wild; Peter Kolkhof; Hartmut Beck; Jörg Keldenich; Metin Akbaba; Mario Jeske
Archive | 2005
Jens-Kerim Ergüden; Gunter Karig; Ulrich Rosentreter; Barbara Albrecht; Kerstin Henninger; Joachim Hütter; Nicole Diedrichs; Peter Nell; Sabine Arndt; Walter Dr. Hübsch; Andreas Knorr; Karl-Heinz Schlemmer; Dirk Brohm
Archive | 2007
Kai Thede; Ingo Flamme; Felix Oehme; Jens-Kerim Ergüden; Friederike Stoll; Hanno Wild; Peter Kolkhof; Hartmut Beck; Mario Jeske
Archive | 2006
Ingo Flamme; Jens-Kerim Ergüden; Felix Oehme; Kai Thede; Gunter Karig; Alexander Kuhl; Hanno Wild; Joachim Schuhmacher; Peter Kolkhof; Lars Bärfacker; Joachim Hütter
Archive | 2000
Toshiya Moriwaki; Chantal Fürstner; Bernd Riedl; Jens-Kerim Ergüden; Frank Böss; Bernard Schmidt; Franz-Josef van der Staay; Werner Schröder; Karl-Heinz Schlemmer; Nagahiro Yoshida
Archive | 2012
Ingo Flamme; Jens-Kerim Ergüden; Felix Oehme; Kai Thede; Gunter Karig; Alexander Kuhl; Hanno Wild; Joachim Schuhmacher; Peter Kolkhof; Lars Bärfacker; Joachim Hütter
ChemMedChem | 2018
Hartmut Beck; Mario Jeske; Kai Thede; Friederike Stoll; Ingo Flamme; Metin Akbaba; Jens-Kerim Ergüden; Gunter Karig; Jörg Keldenich; Felix Oehme; Hans-Christian Militzer; Ingo Hartung; Uwe Thuss
Archive | 2007
Kai Thede; Ingo Flamme; Felix Oehme; Jens-Kerim Ergüden; Friederike Stoll; Joachim Schuhmacher; Hanno Wild; Peter Kolkhof; Hartmut Beck; Jörg Keldenich; Metin Akbaba; Mario Jeske