Jeremy A. Brown

Fabrication and Performance of a 40-MHz Linear Array Based on a 1-3 Composite with Geometric Elevation Focusing

The fabrication and performance of a 256-element high-frequency (40-MHz) linear array is described. The array was fabricated using a high-frequency 1-3 PZT-polymer composite material developed in our laboratory. The spacing of the pillars in the composite was chosen to match the 40-mum center-to-center element spacing of the array electrodes. The element electrodes were created using photolithography, and connections to the electrodes were made using ultrasonic wire bonding. The array was focused in the elevation direction by geometrically shaping the composite material using a cylindrical die with a 6-mm radius of curvature. The resulting transducer produced pulses with a -6 dB two-way bandwidth of 50% and a peak-to-peak pressure of 503 kPa when excited with a plusmn30 V monocycle pulse. The measured one-way ( -6 dB) directivity for a single array element was 24 degrees and the -3 dB one-way elevation beamwidth was measured to be 130 mum. The radiation pattern for a focused 64-element subaperture was measured by mechanically translating the aperture above a needle hydrophone. A -3 dB one-way beamwidth of 97 mum was found at a depth of 6 mm. The one-way radiation pattern decreased smoothly to less than -30 dB at a lateral distance of 640 mum.

Analysis of Vibrant Soundbridge placement against the round window membrane in a human cadaveric temporal bone model.

Objective: To evaluate optimal placement of the Floating Mass Transducer of the Vibrant Soundbridge (Med-El, Innsbruck, Austria) against the round window membrane, particularly the impact of interposed coupling fascia and of covering materials. Methods: Six fresh human cadaveric temporal bones were used. After mastoidectomy, posterior tympanotomy and removal of the round window niche, the Floating Mass Transducer (FMT) of the Vibrant Soundbridge (VSB) was placed against the round window membrane (RWM) in the following ways: in direct contact, or with interposed fascia. Both conditions were combined with a second parameter: no cover over the FMT or covered with fascia, fat or cartilage. The inner ear was stimulated through the VSB with a frequency sweep from 0.1 to 8 kHz at 1 V RMS. Stapedial footplate vibrations were recorded with a PSV-400 Scanning Laser Doppler Vibrometer (Polytec, Waldbronn, Germany). Results: A learning curve exists for optimal placement of the VSB. Sufficient removal of bone around the round window is essential. Without covering materials, there is increased transmission of vibrations if fascia is interposed between the RWM and the FMT. If there is no interposed fascia, vibration transmission is increased with a fascia or fat (but not cartilage) cover. There is no added advantage of cover and interposed fascia, either is as good as the other. Conclusion: Optimal placement of the VSB against the round window relies heavily on surgical precision in placement. There is improved transmission of vibrations with either interposed fascia, or with a covering material.

Radial Modulation Imaging of Microbubble Contrast Agents at High Frequency

In this paper, radial modulation imaging of microbubbles is investigated at high frequency. A modulation pulse frequency of 3.7 MHz with an amplitude ranging from 0 to 250 kPa, and a 1.3-MPa 20-MHz broadband imaging pulse were used. Radial modulation effects were observed on a population of flowing microbubbles and quantified using a Doppler-type processing technique. Artifact signals related to the generation of harmonics by bubbles strongly resonating at the modulation frequency were observed. The bubble response to simultaneous modulation and imaging excitations was simulated for different combinations of bubble sizes and modulation amplitudes. Simulation results confirm the hypothesis that the generation of harmonics of the modulation frequency can be detected by the imaging transducer. Simulations indicate that the modulation frequency should be chosen lower than the resonant frequency of the biggest bubbles present in the population. The simulation also suggests that a 10% variation of bubble diameter induced by the modulation excitation is sufficient for radial modulation imaging. In conclusion, the effects of radial modulation are detectable at a high frequency. Therefore, radial modulation imaging has potential for high-resolution imaging of microbubbles in the microvasculature.

A split-aperture transmit beamforming technique with phase coherence grating lobe suppression

A small element-to-element pitch (~.5λ) is conventionally required for phased array ultrasound transducers to avoid large grating lobes. This constraint can introduce many fabrication difficulties, particularly in the development of high-frequency phased arrays at operating frequencies greater than 30 MHz. In this paper, a new transmit beamforming technique along with sign coherence factor (SCF) receive beamforming is proposed to suppress grating lobes in large-pitch phased-array transducers. It is based on splitting the transmit aperture (N elements) into N/K transmit elements and receive beamforming on all N elements to reduce the temporal length of the transmit grating lobe signal. Therefore, the use of synthetic aperture beamforming, which can introduce relative phase distortions between the echoes received over many transmit events, can be avoided. After each transmit-receive event, the received signals are weighted by the calculated SCF to suppress the grating lobes. After pulsing all sub-apertures, the RF signals are added to generate one line of the image. Simulated 2-way radiation patterns for different K values show that grating lobes can be suppressed significantly at different steering angles. Grating lobes can be suppressed by approximately 20 dB with K = 2 at steering angles greater than 25° and an element pitch greater than 0.75λ. A technique for determining the optimal transmit sub-apertures has been developed.

High-Frequency Ex vivo Ultrasound Imaging of the Auditory System

A 50MHz array-based imaging system was used to obtain high-resolution images of the ear and auditory system. This previously described custom built imaging system (Brown et al. 2004a, 2004b; Brown and Lockwood 2005) is capable of 50 microm axial resolution, and lateral resolution varying from 80 microm to 130 microm over a 5.12 mm scan depth. The imaging system is based on a 2mm diameter, seven-element equal-area annular array, and a digital beamformer that uses high-speed field programmable gate arrays (FPGAs). The images produced by this system have shown far superior depth of field compared with commercially available single-element systems. Ex vivo, three-dimensional (3-D) images were obtained of human cadaveric tissues including the ossicles (stapes, incus, malleus) and the tympanic membrane. In addition, two-dimensional (2-D) images were obtained of an intact cochlea by imaging through the round window membrane. The basilar membrane inside the cochlea could clearly be visualized. These images demonstrate that high-frequency ultrasound imaging of the middle and inner ear can provide valuable diagnostic information using minimally invasive techniques that could potentially be implemented in vivo.

Direct measurement of the wavelength of sound waves in the human skull

The results of a study of the three-dimensional vibration of two dry human skulls in response to harmonic excitation are presented. The vibratory response exhibits three distinct types of motion across the range of audible frequencies. At low frequencies below 1000 Hz, whole-head quasi-rigid motion is seen. At the middle frequencies between 1000 and 6000 Hz, the motion exhibits a series of increasingly complex modal patterns. Above 6000 Hz, the response is wavelike and clear wavefronts can be distinguished in the vibration data. In this regime the relationship between wavelength and frequency is calculated and compared to a number of theories of skull vibration that have been proposed.

Fabrication and performance of high-frequency composite transducers with triangular-pillar geometry

A single-element, 40-MHz, 3-mm diameter transducer was fabricated with a geometric focus at 9 mm. The transducer was based on a piezo-composite substrate with triangular-shaped composite pillars. The 2-way bandwidth of 50% and impedance magnitude were in agreement with that predicted using finite-element modeling. A one-way radiation pattern was collected using a needle hydrophone. The one-way -3 dB beamwidth at the geometric focus was measured to be 120 mum and the -3 dB depth of field was 2.5 mm. This is in good agreement with the theoretical predictions of 112.5 mum and 2.4 mm. The triangular-pillar composite transducer was then compared with a transducer with square composite pillars with similar volume fraction of active ceramic. A 9.5 dB reduction in the amplitude of the secondary resonance was found for the triangular-pillar composite as well as a 30% gain in the 2-way pulse bandwidth. A 256-element 30-MHz linear array was fabricated as a preliminary investigation into the use of the triangular pillar as the substrate in a high-frequency linear array transducer. In vivo images were generated with both the single-element and linear-array transducers.

Long-range, wide-field swept-source optical coherence tomography with GPU accelerated digital lock-in Doppler vibrography for real-time, in vivo middle ear diagnostics.

We present the design, implementation and validation of a swept-source optical coherence tomography (OCT) system for real-time imaging of the human middle ear in live patients. Our system consists of a highly phase-stable Vernier-tuned distributed Bragg-reflector laser along with a real-time processing engine implemented on a graphics processing unit. We use the system to demonstrate, for the first time in live subjects, real-time Doppler measurements of middle ear vibration in response to sound, video rate 2D B-mode imaging of the middle ear and 3D volumetric B-mode imaging. All measurements were performed non-invasively through the intact tympanic membrane demonstrating that the technology is readily translatable to the clinic.

Mass-spring matching layers for high-frequency ultrasound transducers: a new technique using vacuum deposition

We have developed a technique of applying multiple matching layers to high-frequency (>30 MHz) imaging transducers, by using carefully controlled vacuum deposition alone. This technique uses a thin mass-spring matching layer approach that was previously described in a low-frequency (1 to 10 MHz) transducer design with epoxied layers. This mass- spring approach is more suitable to vacuum deposition in highfrequency transducers over the conventional quarter-wavelength resonant cavity approach, because thinner layers and more versatile material selection can be used, the difficulty in precisely lapping quarter-wavelength matching layers is avoided, the layers are less attenuating, and the layers can be applied to a curved surface. Two different 3-mm-diameter 45-MHz planar lithium niobate transducers and one geometrically curved 3-mm lithium niobate transducer were designed and fabricated using this matching layer approach with copper as the mass layer and parylene as the spring layer. The first planar lithium niobate transducer used a single mass-spring matching network, and the second planar lithium niobate transducer used a single mass-spring network to approximate the first layer in a dual quarter-wavelength matching layer system in addition to a conventional quarter-wavelength layer as the second matching layer. The curved lithium niobate transducer was press focused and used a similar mass-spring plus quarter-wavelength matching layer network. These transducers were then compared with identical transducers with no matching layers and the performance improvement was quantified. The bandwidth of the lithium niobate transducer with the single mass-spring layer was measured to be 46% and the insertion loss was measured to be -21.9 dB. The bandwidth and insertion loss of the lithium niobate transducer with the mass-spring network plus quarter-wavelength matching were measured to be 59% and -18.2 dB, respectively. These values were compared with the unmatched transducer, which had a bandwidth of 28% and insertion loss of -34.1 dB. The bandwidth and insertion loss of the curved lithium niobate transducer with the mass-spring plus quarter-wavelength matching layer combination were measured to be 68% and -26 dB, respectively; this compared with the measured unmatched bandwidth and insertion loss of 35% and -37 dB. All experimentally measured values were in excellent agreement with theoretical Krimholtz-Leedom-Matthaei (KLM) model predictions.

Effect of triangular pillar geometry on high- frequency piezocomposite transducers

Piezocomposite materials are used extensively in biomedical transducer array fabrication. However, developing high-frequency piezocomposite materials for imaging systems is still a challenge due to the extremely small pillar dimensions required to avoid the interference from lateral resonances. The use of triangular pillar piezocomposite material has been shown to suppress lateral resonances that appear in square pillar composite designs. To further understand how the geometry of the pillars affects the lateral resonances, piezocomposite materials with triangular pillars of different angles have been simulated and fabricated. Simulations were performed on composite transducers of 70-?m pitch, 18-?m kerf width, and 100-?m thickness with isosceles triangular pillars in which the isosceles angle varied from 30? to 60? using a finite-element analysis. By varying the pillar geometry, the composite transducers show large differences in lateral resonances. The simulation results demonstrate that the composite with 45? angle pillars has the lowest secondary pulse amplitude. The secondary pulse becomes larger when the pillar angle deviates from 45?. To study whether the pillar height (which determines the resonance frequency) and aspect ratio would change the optimum angle, composites with 40-?m pitch, 15-?m kerf width, and 45-?m thickness were also simulated. Finally, the composite with triangle pillars was compared with composites with square and round pillars. The simulation results show that the 45? triangular pillar geometry is, for high-frequency applications, the best configuration among all investigated in this work. Composite samples have also been fabricated to confirm results from finite-element modeling. Acoustical and electrical measurements were carried out to compare with theoretical predictions. Three composite transducers with pillar angles of 30?, 45?, and 60? were fabricated using a dice-and-fill technique. The measured electrical impedances and one-way pulse responses agreed well with the theoretical predictions and confirm the optimal nature of the 45? design.