Jerome S. Harris

Hypertension and renal dynamics in aortic coarctation

Abstract Examination of the changes in blood pressure in both human and experimental aortic coarctation indicates that these alterations cannot be explained solely as a result of the mechanical effects of the lesion. Studies of the renal dynamics before and after operation in human coarctation fail to show a correlation with the blood pressure changes. It is concluded that other mechanisms, besides the increased resistance imposed by the constriction and collaterals, are necessary to explain the hypertension of aortic coarctation. These mechanisms apparently do not involve renal ischemia.