Jerry W. Alexander

The anatomic basis of femoral component design.

The shape of the femoral canal is variable, much more variable, in fact, than most contemporary designs of femoral components would suggest or can accommodate. In the face of this variability, line-to-line or surface-to-surface contact is not expected between cementless implants and much of the endosteal surface. It also is apparent that changes in implant design are still needed if the normal biomechanics of the hip joint are to be restored in each patient and if component fixation is to be optimized. Most cementless components aim to achieve proximal load transfer to the femoral canal. However, increasing clinical evidence suggests that distal filling of the femur also is necessary to minimize the incidence of postoperative symptoms, particularly in revision procedures. If this is indeed the case, more accommodating designs of femoral components are needed that will enable proximal and distal fitting at the femoral canal so that stable fixation may be achieved regardless of variations in bone geometry.

The 2007 Frank Stinchfield Award. The biomechanics of the hip labrum and the stability of the hip.

We explored the mechanical factors leading to the formation of labral tears and the effect of these lesions on hip kinematics at the extremes of joint motion. Using a 3D motion analysis system, the stability of six cadaveric hips was measured during loading maneuvers known to impose anterior loads on the joint margin. These measurements were repeated following venting of the capsule, and after creation of a 15-mm tear in the intact labrum. Compared to the intact hip, 43% and 60% less force was required to distract the femur by 3 mm after venting and creation of a tear. An ER torque of 177 in-lbf in 30° of flexion caused the vented and torn specimens to rotate 1.5° ± 2.7° and 7.1° ± 4.7° more than the intact specimen, and the femoral head to displace 1.21 ± 0.53 mm and 0.67 ± 0.35 mm, respectively. A breach of the integrity of labral function is shown to lead to decreased femoral stability relative to the acetabulum during extreme ranges of motion.

The effect of aging on the shape of the proximal femur.

The design of cementless femoral prostheses is based on the assumption that age and gender do not affect the shape of the proximal femur. To test this hypothesis, standard anteroposterior and lateral radiographs were prepared of 4 sets of 20 femora, obtained from young (range, 40-60 years) and elderly (range, 60-90 years) donors of both genders. The intracortical and extracortical borders of each femur were digitized electronically, and key parameters were measured to define the shape and dimensions of the medullary canal and the position of the femoral head. Systematic differences were observed between the size and shape of male and female femora. Extracortical dimensions were larger in the male femora by 14% to 19%, and endosteal dimensions by 11% to 24%. However, there were no significant differences between the canal shape of young male and young female femora in the coronal, sagittal, or transverse planes. The male femora displayed no significant differences in canal shape or endosteal width as a function of age. Profound differences were observed in the endosteal shape and diaphyseal dimensions of the young and old female femora. The older female femora had wider canals at the level of the isthmus, with a significant reduction in the canal flare index (the ratio between the canal width proximal to the lesser trochanter and at the isthmus). This study demonstrates that cementless femoral prostheses of 1 standard shape cannot provide a close fit to the endosteal contours of young and elderly women.

Posterior cruciate function following total knee arthroplasty: A biomechanical study

The strain developed in the posterior cruciate ligament (PCL) of eight fresh cadaveric knees was measured before and after total knee arthroplasty using a loading technique that simulated stair ascent and descent. Each knee was instrumented with a Hall Effect strain gauge (Micro-Strain, Burlington, VT) in the PCL, a load cell in the quadriceps tendon, an electrogoniometer, and an array of linear displacement transducers to measure femoral rollback. Testing was undertaken with each knee in its normal state with the anterior cruciate cut and with a cruciate-retaining prosthesis, a cruciate-excising prosthesis, and a cruciate-substituting prosthesis. Normal PCL strain levels were produced in only 37% of the trials following implantation of the cruciate-retaining knee arthroplasties. With a cruciate-retaining prosthesis, femoral rollback decreased by an average of 36% and was associated with a 15% loss in extensor efficiency. In the procedures performed with excision of the PCL, rollback decreased by 70% and extensor efficiency by 19%. Cruciate substitution resulted in a 12% loss in rollback and an 11% decrease in extensor efficiency. The strain developed within the PCL during knee flexion was found to be extremely sensitive to the thickness of the polymeric tibial insert. In the majority of cases, it was not possible to restore normal ligament loading with flexion while simultaneously maintaining acceptable varus/valgus stability of the knee joint. Using a range of contemporary knee arthroplasties, the authors were unable to consistently reproduce normal function of the PCL.

The effects of antibiotic-impregnated autogeneic cancellous bone graft on bone healing

Autogeneic canceUous bone graft has been recommended as a vehicle for local antibiotic delivery. Its effect on graft incorporation, however, is unknown. The healing of defects grafted with tobramycin-impregnated cancellous bone were compared with those grafted with cancellous bone alone. Plane roentgenographs, microradiographs, bone density analyses, histologic examination, and biomechanical testing were performed on specimens throughout the course of healing. The presence of large concentrations of local tobramycin does not appear to affect the normal healing characteristics of cancellous bone graft

Effect of Lateral Meniscal Root Tear on the Stability of the Anterior Cruciate Ligament–Deficient Knee

Background: Meniscal root tears are an increasingly recognized subset of meniscal injury. The menisci are critical secondary stabilizers of the anterior cruciate ligament (ACL). The kinematic effect of lateral meniscus posterior root tear in the setting of ACL injury is not known. Purpose/Hypothesis: The purpose of this study was to determine the effect of tear of the lateral meniscal root on stability of the ACL-deficient knee. The hypothesis was that disruption of the lateral meniscal root will further destabilize the ACL-deficient knee during a simulated pivot shift. Study Design: Controlled laboratory study. Methods: Pivot-shift testing of 8 fresh-frozen cadaveric knees was performed after attachment of photoreflective flags and preparation of CT scans. Each knee was mounted in a custom activity simulator and dynamically loaded from 15° to 90° of flexion with all the permutations of the following: iliotibial band force (50, 75, 100, 125, 150, and 175 N), internal rotation moments (1, 2, and 3 N·m), and valgus moments (5 and 7 N·m). In addition, anterior stability tests were performed by applying a 90-N anterior force to the tibia at flexion angles of 15°, 30°, 45°, 60°, and 90°. During each test, the anterior tibial translation and rotation of the tibia were measured with a high-resolution multiple infrared camera motion analysis system for the following 3 conditions: ACL-intact (ACL-I), ACL-deficient (ACL-D), and ACL-deficient/lateral meniscal posterior root avulsion (ACL-D/LMR-A). Results: A pivot-shift phenomenon was observed in the ACL-D and ACL-D/LMR-A conditions. The mean tibial translation of the lateral tibial condyle during the pivot-shift maneuver was 2.62 ± 0.53 mm for the ACL-I knees, 6.01 ± 0.51 mm for the ACL-D knees (P value vs intact: .0005), and 8.13 ± 0.75 mm for the ACL-D/LMR-A knees (P value vs intact: <.0001). During the pivot-shift maneuver, translation was significantly increased in the ACL-D/LMR-A condition compared with the ACL-D condition (P = .0146). Compared with the intact group, anterior tibial translation during the Lachman maneuver also increased at 30° and 90° of flexion in the ACL-D group (P < .0001) and the ACL-D/LM group (P < .0001). No statistically significant difference was found between the ACL-D and ACL-D/LMR-A groups during the Lachman maneuver at 30° and 90° (P = .16 and .72, respectively). Conclusion: A tear of the lateral meniscal posterior root further reduces the stability of the ACL-deficient knee during rotational loading. Clinical Relevance: This study shows that lateral meniscal root injury further destabilizes the ACL-deficient knee and thus advances the concept that the lateral meniscus is a secondary stabilizer of the knee under pivot-shift loading. In the absence of stronger evidence, the study data suggest a rationale for surgical repair of lateral meniscal root tears encountered in the setting of ACL tears.

Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction: Kinematics and Knee Flexion Angle–Graft Tension Relation

PURPOSE The purpose of this study was to compare the bundle tension curves and resultant knee kinematics between 2 tensioning protocols in anatomic double-bundle anterior cruciate ligament (ACL) reconstruction. METHODS Anatomic double-bundle ACL reconstruction was performed in 7 male cadaveric knees. Each graft was tensioned to 22 N under 2 conditions: (1) both bundles tensioned at 20 degrees of knee flexion (20/20 protocol) or (2) posterolateral (PL) bundle tensioned at 15 degrees and anteromedial (AM) bundle at 45 degrees (45/15 protocol). Knee kinematics were recorded in response to anterior and combined rotatory loads in the intact, ACL-deficient, and reconstructed states. Bundle tension was recorded dynamically with knee motion and during each loading test. RESULTS Tensioning both bundles at 20 degrees of knee flexion resulted in a reciprocal bundle tension pattern that was not statistically different; the PL bundle tension was greater than the AM bundle tension in full extension, and the AM bundle tension was greater than the PL bundle tension from 25 degrees to 120 degrees. In the second tensioning protocol, the AM bundle tension was significantly greater than the PL bundle tension at all flexion angles. Both tensioning protocols restored normal knee kinematics. CONCLUSIONS Bundle-tensioning protocol is a variable that has a significant effect on the bundle-loading patterns in double-bundle ACL reconstruction. The 20/20 protocol resulted in AM and PL bundle-loading patterns that were equivalent during dynamic testing, whereas the 45/15 protocol led to excessive tension in the AM bundle in full extension. We recommend equal tensioning of both bundles with the knee at 20 degrees of flexion to restore relatively normal tension curves in each bundle and to avoid excessive stress on the AM bundle. CLINICAL RELEVANCE In double-bundle ACL reconstruction, there is no consensus regarding bundle-tensioning protocols. This study provides data on the individual bundle tension curves that result from 2 commonly used tensioning protocols. These data will assist clinicians as the technique and application of double-bundle ACL reconstruction move forward.

Optimal Location of a Single Distal Interlocking Screw in Intramedullary Nailing of Distal Third Femoral Shaft Fractures

OBJECTIVE This biomechanical study was done to determine the effect of the level of a single distal screw in a static intramedullary (IM) femoral nail on the stability of fixation of a fracture in the distal third of the femur. DESIGN Fifteen composite fiberglass femora were osteotomized transversely in the distal third of the femur. A Grosse-Kempf nail was implanted into the femurs, which were divided into three groups of five specimens. Single screw distal nail locking was varied distal to the osteotomy site for each group at 2.5, 5.0, and 7.5 centimeters, respectively. INTERVENTION All instrumented femurs were mounted on a servohydraulic testing machine and fitted with transducers to measure axial, rotational, and bending displacements. Specimens were cyclically loaded (one hertz) in simultaneous torsion (moment: +/- 10 newton-meters) and axial compression (amplitude: 2,000 newtons) for 500 cycles with a 250-pound abductor force. MAIN OUTCOME MEASUREMENT Data from linear and rotational transducers were sampled at 100 hertz for five cycles before cycling, every 100 cycles of loading, and immediately after cycling. Custom computer software was developed to convert transducer signals into static and dynamic measurements of axial motion (in millimeters), rotation (in degrees), and angulation (in degrees). RESULTS Osteotomy site dynamic rotation increased significantly in specimens locked at 7.5 centimeters when compared with the 2.5-centimeter group. There was minimal difference between the stability of the 5.0-centimeter and 7.5-centimeter groups. There was no significant change in position at the fracture site before or after cyclic loading with respect to axial shortening, rotation, or bending. Both dynamic axial and angular displacements were also unaffected by screw position. CONCLUSION The location of a single distal interlocking screw in static IM nail fixation of distal third femur fractures can significantly affect rotational stability but not axial or angular fixation.

Backside Wear of Modular Ultra-High Molecular Weight Polyethylene Tibial Inserts

BACKGROUND The capture mechanisms of modular tibial total knee components may allow relative micromotion between the insert and the base-plate, leading to wear at the nonarticulating (backside) surface. Although retrieved components often display laxity in the capture mechanism in the unloaded condition, the magnitude of the relative motion that actually occurs under physiologic conditions has not been determined. This study was performed to assess the impact of different modes of knee-loading on the relative micromotion between the insert and the base-plate and the relationship between the duration that the implant had been in situ and the severity of backside wear. METHODS Twenty-one posterior-stabilized total knee replacements of one common design (Insall-Burstein II) were retrieved at one to 100 months after implantation. The extent and severity of backside wear was graded with use of stereomicroscopy. All components were soaked in a bath (of physiologic saline solution at 37 degrees C for four days prior to reassembly. The relative micromotion between the insert and the base-plate of each specimen was measured in vitro in two different conditions: with no axial load and with a combination of loads and torques simulating the stance phase of gait. RESULTS The capture mechanism laxity between the insert and the tibial base-plate in the unloaded condition was approximately eight times larger than the micromotion measured during simulated gait. The capture mechanism laxity allowed a mean (and standard deviation) of 618 +/- 226 micro m of total relative micromotion compared with 103 +/- 54 micro m of relative micromotion during the gait cycle. Under both loading conditions, the predominant direction of interface motion was medial-lateral. No correlation was found between the magnitude of capture mechanism laxity and the relative micromotion measured during simulated gait (p = 0.11). Larger polyethylene protrusions on the backside surface did not correlate with less micromotion (p = 0.48) or with capture mechanism laxity (p = 0.06). CONCLUSIONS For the implant design that was studied, capture mechanism laxity between the modular insert and the base-plate in the unloaded condition was an order of magnitude larger than and not indicative of the micromotion that occurred during simulated physiologic loading. In addition, polyethylene protrusions into the screw-holes of tibial base-plates did not seat or lock the insert in place and reduce relative motion. CLINICAL RELEVANCE While some clearance between the insert and the base-plate is required to allow assembly of modular tibial components at the time of surgery, the amount of relative interface motion during a functional activity such as normal gait, which can produce potentially damaging wear debris, is unknown. However, the compressive forces applied to the articular surface during a functional activity may substantially reduce micromotion between the insert and the base-plate relative to the unloaded condition.

The holding strength of cannulated screws compared with solid core screws in cortical and cancellous bone.

Summary: The comparative holding strength of cannulated screws (CS) versus solid core screws (SCS) has not been reported, although differences exist in the respective diameters of their outer thread and pilot drill holes. Our objectives were to characterize these differences and determine the holding power of CS compared with SCS in cortical and cancellous bone. The dimensions of the Synthes (Paoli, PA) 3.5-mm SCS, 3.5-mm CS, 6.5-mm SCS, and 7.0-mm CS were measured, and the cross-sectional area for thread purchase was calculated. Using adult canine femurs, small-fragment 3.5-mm SCS were inserted in cortical (midshaft) and cancellous (condyle) bone of one limb, and CS were placed in similar locations in the contralateral limb. The same technique was used for large-fragment CS and SCS. Pull-out testing was performed using an MTS machine (MTS Systems, Minneapolis, MN) with axial loads applied at 5 mm/s, and data were analyzed to determine the effects of screw type, location, and size. Differences in CS versus SCS design result in higher cross-sectional areas available for SCS thread purchase. Yet no significant differences exists between screw types (SCS vs. CS) in either cortical or cancellous bone. In cancellous bone, large-fragment screws required more force to pull out than did small screws (p=0.000). The mean force required to pull out smallfragment screws was higher in cortical bone than in cancellous bone (p=0.000). These data suggest that the clinical decision to use CS versus SCS should not be based on pull-out strength.