Jian-Jun Fu

Ainsliatrimers A and B, the First Two Guaianolide Trimers from Ainsliaea fulvioides

Ainsliatrimers A (1) and B (2), the first two guaianolide-type sesquiterpene lactone trimers, together with one new structurally related sesquiterpene dimer ainsliadimer B (3), were isolated from the aerial part of Ainsliaea fulvioides. Their structures were elucidated by spectroscopic techniques, including X-ray crystal diffraction. Both 1 and 2 showed potent cytotoxicites against LOVO and CEM cell lines.

Blumeaenes A-J, Sesquiterpenoid Esters from Blumea balsamifera with NO Inhibitory Activity

Chemical examination of the ethanol extract of the aerial parts of Blumea balsamifera led to the isolation of ten new sesquiterpenoid esters, blumeaenes A-J (1- 10), with 13 known flavonoids. Their structures were determined mainly by use of 1D and 2D NMR spectroscopic techniques. All sesquiterpenoid esters were tested for their inhibitory activity against LPS-induced NO production in RAW264.7 macrophages. Compounds 1, 4 and 5 showed slight inhibitory effect on the production of NO with IC(50) values of 40.06, 46.35 and 57.80 microg/mL, respectively.

Chemical Constituents of Plants from the Genus Geum

by Xiang-Rong Chenga), Hui-Zi Jin*a), Jiang-Jiang Qina), Jian-Jun Fua), and Wei-Dong Zhang*a)b) a) Department of Chemistry and Bioactivity of Traditional Chinese Medicine, School of Pharmacy, Shanghai Jiao Tong University, 800 DongChuan Road, Shanghai 200240, P. R. China (phone: þ86-21-34205989; fax: 86-21-34205989; e-mail: kimhz@sjtu.edu.cn; wdzhangy@hotmail.com) b) Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, 325 GuoHe Road, Shanghai 200433, P. R. China

Chemical constituents from Daphne pedunculata

AIM: To study the chemical constituents from the aerial parts of Daphne pedunculata. METHODS: Column chromatography on silica gel and Sephadex LH-20 were used for the isolation and purification of compounds, and physical properties and spectroscopic techniques were used for structural identification. RESULTS: Eight compounds were isolated from the titled plant, and elucidated as daphnetin (1), daphnoretin (2), daphneticin (3) isodaphneticin (4), (-)-pinoresinol (5), daphneolone (6), β-sitosterol (7), and daucosterol (8). CONCLUSION: All compounds were isolated from this plant for the first time.

γ-Hydroxynitrile glucosides from the seeds of Prinsepia utilis.

γ-Hydroxynitrile glucosides (prinsepicyanosides A-E) were isolated alongside 11 known compounds from seeds of Prinsepia utilis Royle. Their structures were determined by detailed analysis of NMR and MS spectroscopic data. The relative configuration of prinsepicyanoside C was established by Cu-Kα X-ray crystallography. Prinsepicyanoside A, osmaronin, and 4-(hydroxylmethyl)-5H-furan-2-one exhibited borderline antibacterial activity against Salmonella gallinarum, Vibrio parahaemolyticus, and Vibrio cholera with MIC values of 30.1, 20.7, and 22.8μg/mL, respectively.

Chemical constituents of the aerial parts of Aconitum kongboense

0009-3130/11/4705-0854 2011 Springer Science+Business Media, Inc. 1) School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China, fax: 86 021 34205989, e-mail: kimhz@sjtu.edu.cn; wdzhangy@hotmail.com; 2) School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, P. R. China; 3) School of Pharmacy, Second Military Medical University, Shanghai, 200433, P. R. China. Published in Khimiya Prirodnykh Soedinenii, No. 5, p. 746, September–October, 2011. Original article submitted May 18, 2010. Chemistry of Natural Compounds, Vol. 47, No. 5, November, 2011 [Russian original No. 5, September–October, 2011]

Chemical constituents from Verbena officinalis

0009-3130/11/4702-0319 2011 Springer Science+Business Media, Inc. 1) School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China, fax: 021 34205989, e-mail: kimhz@sjtu.edu.cn; wdzhangy@hotmail.com; 2) School of Pharmacy, Second Military University, Shanghai 200433, P. R. China. Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 285–286, March–April, 2011. Original article submitted December 28, 2009. Chemistry of Natural Compounds, Vol. 47, No. 2, May, 2011 [Russian original No. 2, March–April, 2011]