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Jianming Yu

University of Wisconsin–Milwaukee

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Featured researches published by Jianming Yu.

Tetrahedron Letters | 2003

General approach for the total synthesis of the sarpagine related indole alkaloids (+)-Na-methyl-16-epipericyclivine, (-)-alkaloid Q3 and (-)-panarine via the asymmetric Pictet-Spengler reaction

Jianming Yu; Xiangyu Z. Wearing; James M. Cook

The stereospecific total synthesis of (+)-Na-methyl-16-epipericyclivine (1) was completed [from d-(+)-tryptophan methyl ester] in an overall yield of 42% (eight reaction vessels). The optical rotation {[α]D +22.8 (c 0.50, CHCl3)} obtained on this material confirmed that the reported optical rotation {[α]D 0 (c 0.50, CHCl3)} [] was biogenetically unreasonable. The first total synthesis of (−)-alkaloid Q3 (5) and (−)-panarine (6), via the intermediate vellosimine (18), is also described.

Journal of Organic Chemistry | 2003

General approach for the synthesis of sarpagine indole alkaloids. Enantiospecific total synthesis of (+)-vellosimine, (+)-normacusine B, (-)-alkaloid Q3, (-)-panarine, (+)-na-methylvellosimine, and (+)-Na-Methyl-16-epipericyclivine

Jianming Yu; Tao Wang; Xiaoxiang Liu; Jeffrey R. Deschamps; Judith L. Flippen-Anderson; Xuebin Liao; James M. Cook

Journal of Organic Chemistry | 2005

A general strategy for the synthesis of vincamajine-related indole alkaloids: stereocontrolled total synthesis of (+)-dehydrovoachalotine, (-)-vincamajinine, and (-)-11-methoxy-17-epivincamajine as well as the related quebrachidine diol, vincamajine diol, and vincarinol.

Jianming Yu; Xiangyu Z. Wearing; James M. Cook

Neuropharmacology | 2010

Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.

Bradford D. Fischer; Stephanie C. Licata; Rahul V. Edwankar; Zhi-Jian Wang; Shengming Huang; Xiaohui He; Jianming Yu; Hao Zhou; Edward Merle Johnson; James M. Cook; Roman Furtmüller; Joachim Ramerstorfer; Werner Sieghart; Bryan L. Roth; Samarpan Majumder; James K. Rowlett

Journal of Organic Chemistry | 2006

An Improved Total Synthesis of (+)-Macroline and Alstonerine as Well as the Formal Total Synthesis of (−)-Talcarpine and (−)-Anhydromacrosalhine−methine

Xuebin Liao; Hao Zhou; Jianming Yu; James M. Cook

Organic Letters | 2002

Stereospecific, Enantiospecific Total Synthesis of the Sarpagine Indole Alkaloids (E)16-Epiaffinisine, (E)16-Epinormacusine B, and Dehydro-16-epiaffinisine

Jianming Yu; Xuebin Liao; James M. Cook

Journal of Organic Chemistry | 2003

Enantiospecific total synthesis of (-)-(E)16-epiaffinisine, (+)-(E)16-epinormacusine B, and (+)-dehydro-16-epiaffinisine as well as the stereocontrolled total synthesis of alkaloid G.

Jianming Yu; Tao Wang; Xiangyu Z. Wearing; Jun Ma; James M. Cook

Tetrahedron Letters | 2003

The first enantiospecific synthesis of (-)-koumidine via the intramolecular palladium-catalyzed enolate driven cross coupling reaction. The stereospecific introduction of the 19-(Z) ethylidene side chain

Hui Cao; Jianming Yu; Xiangyu Z. Wearing; Chunchun Zhang; Xiaoxiang Liu; Jeffery R. Deschamps; James M. Cook

Medicinal Chemistry Research | 2004

Development of Selective Ligands for Benzodiazepine Receptor Subtypes by Manipulating the Substituents at Positions 3- and 7- of Optically Active BzR Ligands

Xiaoyan Li; Jianming Yu; John R. Atack; James M. Cook

Journal of the American Chemical Society | 2004

Stereocontrolled Total Synthesis of ( -- )-Vincamajinine and ( -- )-11 -Methoxy-17-epivincamajine

Jianming Yu; Xiangyu Z. Wearing; James M. Cook

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James M. Cook

University of Wisconsin–Milwaukee

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Xiangyu Z. Wearing

University of Wisconsin–Milwaukee

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Xiaohui He

University of Wisconsin–Milwaukee

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Qi Huang

University of Wisconsin–Milwaukee

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Xuebin Liao

Tsinghua University

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Dongmei Han

University of Wisconsin–Milwaukee

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Hao Zhou

University of Wisconsin–Milwaukee

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Snjezana Lelas

Harvard University

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Tao Wang

University of Wisconsin–Milwaukee

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Xiaoxiang Liu

University of Wisconsin–Milwaukee

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