Jianping Yong

Multifunctional Radical-Doped Polyoxometalate-Based Host–Guest Material: Photochromism and Photocatalytic Activity

An effective strategy to synthesize multifunctional materials is the incorporation of functional organic moieties and metal oxide clusters via self-assembly. A rare multifunctional radical-doped zinc-based host-guest crystalline material was synthesized with a fast-responsive reversible ultraviolet visible light photochromism, photocontrolled tunable luminescence, and highly selective photocatalytic oxidation of benzylic alcohols as a result of blending of distinctively different functional components, naphthalenediimide tectons, and polyoxometalates (POMs). It is highly unique to link π-electron-deficient organic tectons and POMs by unusual POMs anion-π interactions, which are not only conducive to keeping the independence of each component but also effectively promoting the charge transfer or exchange among the components to realize the fast-responsive photochromism, photocontrolled tunable luminescence, and photocatalytic activity.

Anticancer Advances of Matrine and Its Derivatives

As the second leading cause of death in the world, the total number caused by cancer in 2008 is 1.4 million. The great cancer incidence worldwide increases the search for new, safer and efficient anticancer agents (especially to find the new structures and more active anticancer drugs from the natural products) aiming the prevention or the cure of such illness. For a century, matrine (an alkaloid isolated from sophorae flavescens Ait.) has been widely studied in the field of cancer. This review briefly describes the progress of matrine, its derivatives and their anticancer activity.

Synthesis of glycyrrhetic acid derivatives

Abstract11-Deoxyglycyrrhetinic acid (DGA) (2) was produced by Clemmensen reduction of the C-11 carbonyl of 18β-glycyrrhetic acid (GA) (1). Four derivatives of GA and DGA (3a–3d) were synthesized. Their structures were elucidated using spectral data (IR, mass, 1H, 13C NMR).

Chemical Constituents Isolated from the Fruits of Lonicera maackii

Lonicera maackii (Rupr.) Maxim (Amur honeysuckle in English, gold and silver wood in Chinese) is a kind of deciduous shrub belonging to the family Caprifoliaceae and is native to temperate Asia in northern and western China, Mongolia, Japan, Korea, and Southeastern Russian. In China, Lonicera maackii is an important ornamental plant and street tree, widely planted because of its fragrant flowers, long flowering period, and attractive red fruits, which are usually eaten by birds but are toxic to humans. Chen Yue-kai [1] has studied the total flavonoid content in the flowers, branches, leaves, and fruits of Lonicera maackii. We have studied the volatile constituents of the fruits of Lancer maackii planted in Ningxia Province, China, and 32 compounds were confirmed by GC-MS [2]. Based on this research, we continue to study the chemical constituents, and seven compounds (1–7) were isolated from the fruits of Lonicera maackii for the first time. NMR spectra were recorded on a Bruker AV-400 spectrometer. Column chromatography (CC) was carried out on silica gel (100–200 or 200–300 mesh, Qingdao Marine Chemical Inc., Qingdao, China). Melting points were determined on an X-4 apparatus equipped with a microscope and are uncorrected. Plant Material. The fruits of Lonicera maackii were collected from the campus of Ningxia Medical University, Ningxia Province, China, in October 2010 and air dried naturally. Extraction and Isolation. One kilogram of the air-dried and powdered fruits of Lonicera maackii was dipped in 2 L ethanol for one month and then filtered. The solution was concentrated and the residue was rechromatographed over a column of silica gel with eluents of petroleum ether, petroleum ether–ethyl acetate (5:1 to 1:1), ethyl acetate, and chloroform–methanol (10:1 to 1:1) to produce compounds (1–7).

Chemical Components Isolated from the Roots of Morinda officinalis

Morinda officinalis F. C. How is “one of the top four south authentic traditional Chinese medicines,” widely distributed in South District of China, such as Fujian, Guangdong, Guangxi, Hainan, etc. Its roots are widely used for the treatment of sexual impotence, spermatorrhea, irregular menstruation, and female infertility [1]. Gu Bing [2] reported that alcohol extracts of Morinda officinalis possess antioxidant activity; Liu Xiao reported that polysaccharides of Morinda officinalis decrease blood glucose and possess antioxidant activity [3]; Liu Jianjin reported that polysaccharides of M. officinalis can relieve oxidative stress and heal injury to nerve cells in the hippocampus. It can also be used to treat congitive-hehavior disorders in an experimental model of depression in rats [4]; Li Yan et al. reported that water extracts of M. officinalis possess antibacterial activity [5]; Chen Lan et al. reported that alcohol extracts of M. officinalis have antirheumatoid arthritis and antiinflammatory activities [6]. However, these biological investigations are focused on a mixture of different extracts. In order to confirm the specific biological components, provide scientific evidence for the effective use of this special plant medicine, and find new structural compounds from this plant, our research group took the lead to study this local “special plant medicine.” In this work, we isolated 11 compounds: fumaric acid (1) [7], 3 -sitosterol (2) [8], sucrose (3) [9], glucose (4) [10], 7-hydroxy-6methoxycoumarin (5) [11], palmitic acid (6) [12], and anthraquinones (7–11) [13–18] from the roots of M. officinalis. NMR spectra were recorded on a Bruker AV-400 spectrometer. Column chromatography (CC) was carried out on silica gel (100–200 or 200–300 mesh, Qingdao Marine Chemical Inc., Qingdao, China). Melting points were determined on an X-4 apparatus equipped with a microscope and are uncorrected. Plant Material. The roots of Morinda officinalis was collected in July of 2011 from the Longyan of Fujian Province, China. Extraction and Isolation. Dry powdered roots (2.5 kg) of Morinda officinalis was dipped in 20 L alcohol at room temperature for five months and then filtered. The filtration was concentrated under reduced pressure, and the residue was directly chromatographed over a column of silica gel with an eluent of petroleum ether, petroleum ether–ethyl acetate (5:1 to 1:1), petroleum ether–acetone, ethyl acetate, and chloroform–methanol (10:1 to 0:1) to obtain several fractions. These fractions were isolated by column chromatography (CC) together with preparative thin layer chromatography (P-TLC) to obtain 11 known compounds (1–11). The isolated compounds were analyzed by NMR spectra and XRD. The data agree well with literature data.

Synthesis of (Z/E)-11-tetradecen-1-ol, a component of Ostrinia nubilalis sex pheromone

Abstract11-Tetradecen-1-ol acetate is a mixture of geometric isomers with the Z/E-conformations in a 94:6 ratio that is used as an attractant to trap corn pests. It has a powerful attractive action similar to that of an isomeric mixture of 11-tetradecenyl acetate with the Z/E-conformation in a 95:5 ratio that was extracted from the peritoneal cavity of male Ostrinia nubilalis Hubner in Xinjing (PRC).

Synthesis, Structural Characterization of a Novel Ferrocene Derivative and Preliminarily Anticancer Activity

A novel structure of ferrocene derivative 1 was synthesized with cyanuric chloride and ferrocenemethanol as starting materials. The synthesized compound was fully characterized using 1H NMR, 13C NMR, MS and XRD. Subsequently, the in vitro anticancer effect against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated by the MTT method. The result showed that this compound exhibits good cytotoxic effect on A549, HCT116 and MCF-7 cell lines.

Chemical Constituents of Lonicera maackii

Lonicera maackii (Rupr.) Maxim. (Amur honeysuckle in English, gold and silver wood in Chinese) is a kind of deciduous shrub belonging to the family of Caprifoliaceae and is native to temperate Asia in northern and western China, Mongolia, Japan, Korean, and Southeast of Russian. In China, Lonicera maackii is widely planted at the street side and in public gardens to beautify the environment and for sightseeing because of its fragrant flowers, long flowering period, and attractive red fruits; the fruits are usually eaten by birds but is toxic to humans. Chen Yue-kai [1] has studied the total flavonoid content in the flowers, branches, leaves, and fruits of Lonicera maackii. We have studied the volatile constituents by GC-MS [2] and isolated seven compounds [3] from the fruits of L. maackii planted in Ningxia Province, China. Based on these studies, we continue to study this plant to find new structural compounds. In this work, chlorogenic acid (CA, 1) was isolated from the flower, and six known triterpene compounds (2–7) were isolated for the first time from the fruits of Lonicera maackii. NMR spectra were recorded on a Bruker Biospin Avance III spectrometer. Column chromatography (CC) was carried out on silica gel (100–200 or 200–300 mesh, Qingdao Marine Chemical Inc., Qingdao, China). Melting points were determined on an X-4 apparatus equipped with a microscope and are uncorrected. Plant Material. The flower was collected from the campus of Ningxia Medical University (Ningxia Province, China) in April of 2010 and air dried naturally. The fruits of Lonicera maackii were collected from the campus of Ningxia Medical University in October of 2010 and air dried naturally. Extraction and Isolation. The dry powdered flower of Lonicera maackii (50 g) was extracted by ultrasonic wave with 95% ethanol for three times. The combined extract was concentrated under reduced pressure. The residue was rechromatographed over a column of silica gel with chloroform–methanol (10:1 to 1:1) eluent to obtain chlorogenic acid (1). The air-dried and powdered fruits (1 kg) of Lonicera maackii were dipped in 2 L chloroform for one month and then filtered; the filtrate was concentrated, and the residue was rechromatographed directly over a column of silica gel with eluents of petroleum ether, petroleum ether–ethyl acetate (5:1 to 1:1), pertroleum ether–acetone, ethyl acetate, and chloroform–methanol (10:1 to 1:1) to obtain several fractions. The fractions were isolated by preparative thin-layer chromatography (PTLC) to obtain six known triterpene compounds (2–7).

Progress of novel compounds with anticancer activity

Received: March 05, 2018; Accepted: March 30, 2018; Published: April 03, 2018 Cancer is one of the major causes of human death worldwide. The death caused by cancer mainly is lung cancer, breast cancer, liver cancer, carcinoma of colon and rectum. It is estimated that about 1,688,780 new cancer cases will be diagnosed in the United States in 2017 and 600,920 cancer cases are expected to die, which is about 1,650 people per day. For all sites combined, the cancer incidence rate is 20% higher in men than in women, while the cancer death rate is 40% higher [1]. It has been reported that 4,292,000 new cancer cases and 2,814,000 cancer deaths occurred in 2015 in China, with lung cancer being the most common incident cancer and the leading cause of cancer death. Stomach, esophageal, and liver cancers were also commonly diagnosed and were identified as leading causes of cancer death [2].

Synthesis of A Novel Ferrocene Derivative and Cytotoxicity to A549, HCT116and MCF-7 Cell Lines

Based on our previous results, a ferrocene derivative 1 was synthesized in this study and characterized by 1H NMR, 13C NMR, MS and XRD methods. And then, the cytotoxicity to A549, HCT116 and MCF-7 cell lines was evaluated using the MTT method. The results showed that this compound exhibited good cytotoxicity to A549, HCT116 and MCF-7 cell lines.