Jin-wu Yan

A colorimetric and fluorometric NBD-based chemosensor for highly selective recognition of palladium(II) cations

A chemosensor NBD-PMA with colorimetric and fluorometric responses for Pd2+ cations has been described. NBD-PMA selectively coordinated Pd2+ cations with a colour change from bright yellow to pink, which enabled detection of Pd2+ cations in environmental water samples with the naked eye. NBD-PMA also exhibited high selectivity and sensitivity for Pd2+ cations in fluorometry even in the presence of other metal cations, which makes it practically applicable for detecting Pd2+ cations in environmental samples and in living cells.

CV-APC, a colorimetric and red-emitting fluorescent dual probe for the highly sensitive detection of palladium

A highly sensitive colorimetric and red-emitting fluorescent dual probe was synthesized and applied to imaging palladium species based on the Tsuji–Trost reaction. Notably, it displayed specific and turn-on fluorescent response toward Pd0 with a vivid color change from yellow to purple in aqueous media. The detection limit was calculated to be as low as 0.78 nM. Furthermore, the probe was successfully applied for fluorescence imaging of palladium in living cells. All these properties made this probe a promising useful tool not only in environmental detection but also more widely in bioanalytical fields.

Development of a colorimetric and NIR fluorescent dual probe for carbon monoxide

Carbon monoxide (CO) has captivated great attention in part due to the discovery of the therapeutic and cell-signalling role that CO plays in biological systems. The ever-increasing interest in CO has resulted in the development of rapid and facile approaches for the sensitive and selective detection of CO, which still remains challenging. Herein, the first example of a colorimetric and near-infrared fluorescent dual probe for carbon monoxide (CO) has been developed by assembling an allyl chloroformate moiety with a naphthofluorescein fluorophore, which enables the label-free and visual detection of CO. The living cell imaging results indicate that the probe shows great potential in sensing intracellular CO.

Correction: A colorimetric and far-red fluorescent probe for the highly sensitive detection of silver(I)

Correction for ‘A colorimetric and far-red fluorescent probe for the highly sensitive detection of silver(I)’ by Yong-jun Wang et al., RSC Adv., 2017, 7, 55567–55570.

Piperazine-tuned NBD-based colorimetric and fluorescent turn-off probes for hydrogen sulfide

The piperazine ring is a very important factor in governing molecular structure to generate the special properties of a compound. New NBD-based fluorescent probes 1–3 were designed and synthesized for hydrogen sulfide (H2S) detection. Probe 1 showed high sensitivity and selectivity for H2S with a color change from yellow to pink for naked eye observation. However, the analogues (2 and 3) were response-negative toward H2S. In order to clarify the importance of the piperazine ring in the NBD-based H2S probe and the mechanism, the crystal structure of 1 was obtained and the piperazine ring was deemed to mediate H2S nucleophilic addition. In addition, probe 1 had limits of detection of 18.96 μM (UV) and 23.42 μM (FL), and the thiolysis rate for 1 was found to be 0.49 M−1 s−1. Living cell imaging results indicated that probe 1 could be utilized to trace intracellular H2S. This work has a great guiding role in the design of NBD-based fluorescent probes through a nucleophilic addition mechanism.

Ultrasensitive ELISA for the detection of hCG based on assembled gold nanoparticles induced by functional polyamidoamine dendrimers

Amplifying the signal of ELISA is important in the early disease diagnosis. Herein we report an ultrasensitive ELISA applying for the detection of hCG based on the assemble of AuNPs induced by functional PAMAM. The AuNP-PAMAM probe shows a competitive advantage sensitivity of 0.03 IU L-1 compared to traditional ELISA and mAb1-AuNP-HRP probe. The line range is ranged from 0.1 to 6.4 IU L-1. Moreover, the precision and reproducibility and specificity of AuNP-PAMAM probe are also eligible for the detection of hCG. The assembled AuNPs was firstly used in the signal enhancement in immunoassay.

A colorimetric and far-red fluorescent probe for the highly sensitive detection of silver(I)

Herein, a potential colorimetric and far-red fluorescent probe DCPS-1 for Ag+ was rationally developed based on a dicyanomethylene-4H-chromene chromophore. Its prominent and distinct changes in both color and fluorescence enable the on-site and naked-eye detection of Ag+ easily and quickly, accompanied with excellent sensitivity. No absorption and fluorescence response could be observed towards other metal ions. The fluorescence intensity of this probe showed a linear response to Ag+ in the concentration range of 0–10 μM with a detection limit of 21.1 nM. In addition, this probe had low toxicity to cells and gave distinct fluorescence changes in cell imaging. All these results demonstrate its promising application prospects for Ag+ sensing in both environmental and biology fields.