Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Jingwei He is active.

Publication


Featured researches published by Jingwei He.


Dental Materials | 2012

Incorporation of an antibacterial and radiopaque monomer in to dental resin system

Jingwei He; Eva Söderling; Lippo V.J. Lassila; Pekka K. Vallittu

OBJECTIVES The purpose of this study was to prepare antibacterial and radiopaque dental resin through adding one polymerizable quaternary ammonium compound with iodine as counter anion into Bis-GMA/TEGDMA (50/50, wt/wt) dental resin system, and evaluate the degree of monomer conversion, mechanical properties, radiopacity, and antibacterial effectiveness of the polymer. METHODS 2-Dimethyl-2-dodecyl-1-methacryloxyethyl ammonium iodine (DDMAI) (3 wt.% and 5 wt.%) was added into a Bis-GMA/TEGDMA (50/50, wt/wt) resin system with CQ (0.7 wt.%) and DMAEMA (0.7 wt.%) as photoinitiation system. Degree of monomer conversion (DC) was determined by FT-IR analysis. The flexural strength (FS) and flexural modulus (FM) of the polymer were measured using a three-point bending set up. Radiographs were taken to determine the radiopacity of the polymer, and aluminum step-wedge (0.5-4mm) was used as calibration standard. A single-species biofilm model with Streptococcus mutans as the tests organism was used to evaluate the antibacterial property of the polymer. Bis-GMA/TEGDMA without DDMAI was used as control material in all of the tests. RESULTS ANOVA analysis revealed that there was no significant difference in DC between polymer with and without DDMAI (p>0.05). Polymer with 3 wt.% DDMAI had higher FS than the control material (p<0.05), while polymer with 5 wt.% DDMAI had comparable FS with the control material (p>0.05). Though average FM of control material was lower than that of 3 wt.% DDMAI containing polymer and higher than 5 wt.% DDMAI containing polymer, but the differences were statistically insignificant. By increasing the quantity of DDMAI, the radiopacity of the polymer increased. Of the three formulations, the polymer with 5 wt.% DDMAI inhibited biofilm the formation of the clinically relevant young biofilm. SIGNIFICANCE Incorporation of DDMAI into resin system could endow it with radiopacity and antibacterial effectiveness, and these two properties seem to be improved with increasing the quantities of DDMAI.


Dental Materials | 2015

Preparation of antibacterial and radio-opaque dental resin with new polymerizable quaternary ammonium monomer

Jingwei He; Eva Söderling; Lippo V.J. Lassila; Pekka K. Vallittu

OBJECTIVE A new polymerizable quaternary ammonium monomer (IPhene) with iodine anion was synthesized and incorporated into Bis-GMA/TEGDMA (50/50, wt/wt) to prepare antibacterial and radio-opaque dental resin. METHODS IPhene was synthesized through a 2-steps reaction route, and its structure was confirmed by FT-IR and (1)H-NMR spectra. IPhene was incorporated into Bis-GMA/TEGDMA (50/50, wt/wt) with a series of mass fraction (from 10 wt.% to 40 wt.%). Degree of monomer conversion (DC) was determined by FT-IR analysis. Polymerization shrinkage was determined according to the variation of density before and after polymerization. The flexural strength, modulus of elasticity, and fracture energy were measured using a three-point bending set up. Radiograph was taken to evaluate the radio-opacity of the polymer. A single-species biofilm model with Streptococcus mutans (S. mutans) as the tests organism was used to evaluate the antibacterial activity of the polymer. Bis-GMA/TEGDMA resin system without IPhene was used as a control group. RESULTS FT-IR and (1)H-NMR spectra of IPhene revealed that IPhene was the same as the designed structure. ANOVA analysis showed that when mass fraction of IPhene was more than 10 wt.%, the obtained resin formulation had lower DC, polymerization shrinkage, FS, and FM than control resin (p<0.05). Polymers with 20 wt.% and 30 wt.% IPhene had higher fracture energies than control polymer (p<0.05). IPhene containing samples had higher radio-opacity than control group (p<0.05), and radio-opacity of IPhene containing sample increased with the increasing of IPhene mass fraction (p<0.05). Only polymers with 30 wt.% and 40 wt.% of IPhene showed antibacterial activity (p<0.05). SIGNIFICANCE IPhene could endow dental resin with both antibacterial and radio-opaque activity when IPhene reached 30 wt.% or more. Though sample with 30 wt.% of IPhene had lower FS and FM than control group, its lower volumetric shrinkage, higher fracture energy, higher radio-opacity, and antibacterial activity still made it having potential to be used in dentistry.


Dental Materials | 2014

Synthesis of none Bisphenol A structure dimethacrylate monomer and characterization for dental composite applications.

Xiaoxu Liang; Fang Liu; Jingwei He

OBJECTIVE In this study, new dimethacrylate monomer SiMA without Bisphenol A (BPA) structure was synthesized and used as base resin of dental composite materials with the aim of reducing human exposure to BPA derivatives. METHODS SiMA was synthesized through ring-opening addition reaction between 1,3-bis[2(3,4-epoxycyclohex-1-yl)ethyl]tetra-methyldisiloxane and methacrylic acid, and its structure was confirmed by FT-IR and (1)H NMR spectra. SiMA was mixed with TEGDMA (50/50, wt/wt) and photoinitiation system (0.7 wt% of CQ and 0.7 wt% of DMAEMA) to form resin system. Experimental composite EC was then prepared by SiMA based resin loading with BaAlSiO2 microfillers (72wt%). Double bond conversion (DC) was determined by FT-IR analysis. Volume shrinkage (VS) was measured through variation of density before and after irradiation. Water sorption (WS) and solubility (SL) were obtained until the mass variation of polymer in distilled water kept stable. Flexural strength (FS) and modulus (FM) of the polymer were measured using a three-point bending set up. Extract of composite was used to evaluate its cytotoxic effect on humane dental pulp cells, and relative growth rate (RGR) was obtained by CCK-8 assay. Bis-GMA/TEGDMA (50/50, wt/wt) resin system and universal dental restorative materials 3M ESPE Filtek™ Z250 were used as references for neat resin system and composite material, respectively. RESULTS FT-IR and (1)H NMR spectra showed that structure of SiMA was the same as designed. For the neat resin systems: DC of SiMA based resin was higher than that of Bis-GMA based resin (p<0.05); SiMA based resin had lower VS than Bis-GMA based resin; WS of SiMA based resin was lower than that of Bis-GMA based resin (p<0.05), while SL of SiMA based resin was nearly the same as that of Bis-GMA based resin (p>0.05); FS and FM of SiMA based resin were lower than those of Bis-GMA based resin (p<0.05). For the composite materials: DC of EC was higher than that of Z250 (p<0.05); EC and Z250 had same VS; WS of EC was lower than that of Z250 (p<0.05), and SL of EC was higher than that of Z250 (p<0.05); FS and FM of EC were lower than those of Z250 (p<0.05); RGRs of EC were lower than those of Z250 after the cells were incubated with relative extract for 24h and 48h (p<0.05), while after being incubated for 72 h, RGR of EC and Z250 had no obvious difference (p>0.05). SIGNIFICANCE SiMA had potential to replace Bis-GMA as base resin of dental composite materials. However, formulation of SiMA based resin and composite should be optimized in terms of mechanical strength to satisfy the requirements of resin based dental materials for clinical application.


International Journal of Molecular Sciences | 2013

Preparation and Evaluation of Dental Resin with Antibacterial and Radio-Opaque Functions

Jingwei He; Eva Söderling; Pekka K. Vallittu; Lippo V.J. Lassila

In order to prepare antibacterial and radio-opaque dental resin, a methacrylate monomer named 2-Dimethyl-2-dodecyl-1-methacryloxyethyl ammonium iodine (DDMAI) with both antibacterial and radio-opaque activities was added into a 2,2-bis[4-(2-hydroxy-3-methacryloyloxypropyl)-phenyl]propane (Bis-GMA)/methyl methacrylate (MMA) dental resin system. Degree of conversion (DC), flexural strength (FS) and modulus (FM), water sorption (WS) and solubility (WSL), antibacterial activity, and radio-opacity (ROX) of the obtained dental resin system were investigated. Bis-GMA/MMA resin system without DDMAI was used as a control. The results showed that DDMAI could endow BIS-GMA/MMA resin system with good antibacterial (p < 0.05) and radio-opaque function without influencing the DC (p > 0.05). However, incorporating DDMAI into Bis-GMA/MMA resin could reduce mechanical properties (p < 0.05) and increase WS and WSL (p < 0.05), thus further work is needed in order to optimize the resin formulation.


Dental Materials | 2014

Synthesis of antibacterial and radio-opaque dimethacrylate monomers and their potential application in dental resin

Jingwei He; Eva Söderling; Lippo V.J. Lassila; Pekka Vallittu

OBJECTIVE In this study, three dimethacrylate quaternary ammonium compounds N,N-bis[2-(3-(methacryloyloxy)propanamido)ethyl]-N-methyldodecyl ammonium iodide (QADMAI-12), N,N-bis[2-(3-(methacryloyloxy)propanamido)ethyl]-N-methylhexadecyl-ammonium iodide (QADMAI-16), and N,N-bis[2-(3-(methacryloyloxy)propanamido)ethyl]-N-methyloctadectyl ammonium iodide (QADMAI-18) were synthesized and proposed to be used as antibacterial and radio-opaque agents in dental resin. METHODS All QADMAIs were synthesized through a 2-steps reaction route, and their structures were confirmed by FT-IR and 1H NMR spectra. Antibacterial activities against Streptococcus mutans (S. mutans) of QADMAIs were measured by agar diffusion test. Each QADMAI was mixed with TEGDMA (50/50, w/w) and photoinitiation system (0.7 wt% of CQ and 0.7 wt% of DMAEMA) to form resin system. Degree of monomer conversion (DC) was determined by FT-IR analysis. The flexural strength (FS) and modulus (FM) of the polymer were measured using a three-point bending set up. Radiograph was taken to determine the radio-opacity of the polymer, and aluminum step-wedge (0.5-4 mm) was used as calibration standard. Surface charge density was measured using fluorescein binding. A single-species biofilm model with S. mutans as the tests organism was used to evaluate the antibacterial property of the polymer. Bis-GMA/TEGDMA resin system was used as control material in all of the tests. RESULTS FT-IR and 1H NMR spectra showed that the structures of QADMAIs were the same as designed. ANOVA analysis revealed that antibacterial activity of QADMAI decreased with the increasing of alkyl chain length (p<0.05). QADMAI containing polymers had higher DC (p<0.05) but lower FS and FM (p<0.05) than control polymer. Alkyl chain length had no influence on DC (p>0.05), but FS and FM of QADMAI-12 containing polymer were better than those of QADMAI-16 and QADMAI-18 containing polymers (p<0.05). QADMAI containing polymers had much better radio-opacity than control polymer (p<0.05), and the radio-opacity of polymer decreased with the increasing of alkyl chain length (p<0.05). All of QADMAIs containing polymers had higher surface charge density than control polymer (p<0.05), and surface charge densities of QADMAI-12 and QADMAI-16 containing polymers were nearly the same (p>0.05) which were higher than that of QADMAI-18 containing polymer (p<0.05). All of QADMAI containing polymers had good inhibitory effect on biofilm formation. SIGNIFICANCE QADMAIs had no miscibility problem with TEGDMA, and QADMAIs could endow dental resin with both antibacterial activity and radio-opacity. Formulation of QADMAI containing resin should be optimized in terms of mechanical stregth to satisfy the requirements of dental resin for clinical application.


Journal of Biomaterials Science-polymer Edition | 2013

Investigation of double bond conversion, mechanical properties, and antibacterial activity of dental resins with different alkyl chain length quaternary ammonium methacrylate monomers (QAM)

Jingwei He; Eva Söderling; Pekka K. Vallittu; Lippo V.J. Lassila

In order to endow dental resin with antibacterial activity, a series of antibacterial quaternary ammonium methacrylate monomers (QAM) with different substituted alkyl chain length (from 10 to 18) were incorporated into commonly used 2,2-bis[4-(2′-hydroxy-3′-methacryloyloxy-propoxy)-phenyl]propane (Bis-GMA)/triethyleneglycol dimethacrylate (TEGDMA) (50 wt/50 wt) dental resin as immobilized antibacterial agents. Double bond conversion (DC), flexural strength (FS) and modulus (FM), and young and mature biofilms inhibition effectiveness of prepared dental resins were studied and Bis-GMA/TEGDMA without QAM was used as reference. Results showed that there was no significant difference on DC, FS, and FM between copolymer with and without 5 wt% QAM. Substituted alkyl chain length of QAM had no influence on DC, FS, and FM of copolymer, but had influence on antibacterial activity of copolymer. Antibacterial activity of copolymer increased with increasing of substituted alkyl chain length of QAM, and the sequence followed as 5%C10 < 5%C11≈5%C12 < 5%C16≈5%C18. Copolymers containing C18 and C16 had the best inhibition effectiveness on both young biofilm and mature biofilm, copolymers containing C12 and C11 only had inhibition effectiveness on young biofilm and copolymer containing C10 had none inhibition effectiveness on neither young biofilm nor mature biofilm.


Journal of Biomaterials Applications | 2010

Synthesis and Characterization of a New Trimethacrylate Monomer with Low Polymerization Shrinkage and its Application in Dental Restoration Materials

Jingwei He; Yuanfang Luo; Fang Liu; Demin Jia

In this study, a new trimethacrylate monomer α,α,α′-tri[4-(2′-hydroxy-3′-methacryloyloxy-propoxy)phenyl]-1-ethyl-4-isopropylbenzene (α,α,α′-THMPEIB) with a molecular weight of 850 and a large molecular volume was designed and synthesized. The structure of monomer α,α,α′-THMPEIB was confirmed by FT-IR, 1H NMR, and elemental analysis. Degree of double-bond conversion, volume shrinkage, water sorption and solubility, diffusion coefficient value, and flexure strength of α,α,α′-THMPEIB/tri(ethylene glycol) dimethacrylate- (TEGDMA) based resin were measured. 2,2-Bis[4-(2′-hydroxy-3′-methacryloyloxy-propoxy)-phenyl]-propane (bis-GMA)/TEGDMA monomer mixture was used as reference. The result showed that the α,α,α′-THMPEIB/TEGDMA-based resin had the lower double-bond conversion, polymerization shrinkage, and water solubility than bis-GMA/TEGDMA-based resin. Water sorption and diffusion coefficient value of α,α,α′-THMPEIB/TEGDMA-based resin were nearly the same as those of bis-GMA/TEGDMA-based resin. Flexural strength of α,α,α′-THMPEIB/TEGDMA-based resin was higher than that of bis-GMA/ TEGDMA-based resin.


Journal of The Mechanical Behavior of Biomedical Materials | 2016

Physical and chemical properties of an antimicrobial Bis-GMA free dental resin with quaternary ammonium dimethacrylate monomer

Qiting Huang; Jingwei He; Zhengmei Lin; Fang Liu; Lippo V.J. Lassila; Pekka K. Vallittu

The objective of this study was to evaluate the antibacterial activity, physicochemical properties of the quaternary ammonium dimethacrylate monomer N,N-bis[2-(3-(methacryloyloxy)propanamido)-ethyl]-N-methylhexadecyl ammonium bromide (IMQ-16) containing diurethane dimethacrylate (UDMA)/tricyclodecane dimethanol diacrylate (SR833s) resin system and compare with bisphenylglycidyl dimethacrylate (Bis-GMA)/triethylene glycol dimethacrylate (TEGDMA) resin system. It was hypothesized that the physical and chemical properties of the experimental polymers would be comparable with Bis-GMA/TEGDMA polymer and IMQ-16 monomer could endow the UDMA/SR833s resin with antibacterial activity. Double bond conversion (DC) was measured using Fourier transform infrared spectroscopy (FTIR). Mechanical properties including flexural strength (FS) and flexural modulus (FM) were measured by three-point bending test with bars of 2mm×2mm×25mm. Water sorption (WS) and solubility (WSL) were also investigated. Antibacterial activity of obtained polymers against Streptococcus mutans Ingbitt (S. mutans) was tested through direct contact test (DCT). The presence of antibacterial activity due to soluble components was also investigated by agar diffusion test (ADT). All of the polymers containing IMQ-16 exhibited improvements in WS and WSL, while maintaining equivalent DC and FS relative to the Bis-GMA/TEGDMA control system. Incorporation of 17% and 20% of IMQ-16 into UDMA/SR833s resin reduced the viable counts of S. mutans after incubation on the surface of the materials and produced no inhibition zones around the cured discs in ADT. UDMA/SR833s resin system is promising to formulate an antibacterial polymer with equivalent or even higher physicochemical properties relative to Bis-GMA/TEGDMA formulation. IMQ-16 is capable to endow UDMA/SR833s resin system with significant antibacterial activity when the mass ratio is 17% or 20%.


Journal of Biomaterials Science-polymer Edition | 2013

Synthesis and characterization of new dimethacrylate monomer and its application in dental resin.

Jingwei He; Fang Liu; Pekka K. Vallittu; Lippo V.J. Lassila

In this study, a dimethacrylate monomer, 1,4-Bis[2-(4-(2′-hydroxy-3′-methacryloyloxy-propoxy)phenyl)-2propyl]benzene (BMPPB) was synthesized to replace 2,2-bis[4-(2′-hydroxyl-3′-methacryloyloxy-propoxy)phenyl]propane (Bis-GMA) as one component of dental restorative materials. The structure of BMPPB and its intermediate product 1,4-bis[2-(4-(oxiranylmethoxy)phenyl)-2propyl]benzene (BOPPB) were confirmed by Fourier transform infrared (FTIR) spectroscopy, proton nuclear magnetic resonance spectroscopy (1H-NMR), and elemental analysis. In order to evaluate the possibility of replacing Bis-GMA with BMPPB in dental resin, double bond conversion (DC), polymerization shrinkage, contact angle, water sorption (WS) and solubility (SL), and flexural strength (FS) and modulus of BMPPB/tri(ethylene glycol)dimethacrylate (TEGDMA) (50/50 wt) resin system and Bis-GMA/BMPPB/TEGDMA (25/25/50 wt) resin system were studied. Commercially used Bis-GMA/TEGDMA (50/50 wt) dental resin system was used as reference. The results showed that BMPPB-contained copolymer had higher DC, higher WS and SL than the copolymer that only contained Bis-GMA (p < 0.05). All of the copolymers had nearly the same contact angle (p > 0.05). BMPPB/TEGDMA resin system had lower polymerization shrinkage, higher FS and modulus (p < 0.05) than Bis-GMA/TEGDMA resin system. There was no significant difference on polymerization shrinkage, FS and modulus (p > 0.05) between Bis-GMA/BMPPB/TEGDMA resin system and Bis-GMA/TEGDMA resin system. Before and after water immersion, both FS and modulus of every copolymer did not change significantly (p > 0.05). Therefore, BMPPB had potential to be used to replace Bis-GMA as base resin in dental restorative materials, but many studies should be undertaken further.


Journal of The Mechanical Behavior of Biomedical Materials | 2016

Preparation and characterization of Bis-GMA free dental resin system with synthesized dimethacrylate monomer TDDMMA derived from tricyclo[5.2.1.0(2,6)]-decanedimethanol

Mei Yin; Fang Liu; Jingwei He

As a substitute for 2,2-bis[4-(2-hydroxy-3- methacryloxypropoxy)phenyl] propane (Bis-GMA) in dental materials, a new dimethacrylate monomer TDDMMA without bisphenol-A structure was synthesized through the reaction between tricyclo[5.2.1.0(2,6)]- decanedimethanol and 2-isocyanatoethyl methacrylate. The TDDMMA was mixed with triethylene glycol dimethacrylate (TEGDMA) to prepare Bis-GMA free dental resin. Physicochemical properties, such as double bond conversion (DC), polymerization shrinkage (VS), water sorption (WS) and solubility (SL), flexural strength (FS) and modulus (FM) and fracture energy of TDDMMA/TEGDMA resin system were investigated. Bis-GMA/TEGDMA resin system was used as a control. The results showed that, compared with Bis-GMA/TEGDMA resin system, TDDMMA/TEGDMA resin system had comparable VS and several advantages like higher DC, lower SL and better mechanical properties after water immersion.

Collaboration


Dive into the Jingwei He's collaboration.

Top Co-Authors

Avatar

Fang Liu

South China University of Technology

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Yuanfang Luo

South China University of Technology

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Demin Jia

South China University of Technology

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Wenbin Zhu

South China University of Technology

View shared research outputs
Top Co-Authors

Avatar

Xiaoxu Liang

South China University of Technology

View shared research outputs
Researchain Logo
Decentralizing Knowledge