Jiyoon Bu
KAIST
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Publication
Featured researches published by Jiyoon Bu.
Biosensors and Bioelectronics | 2017
Jiyoon Bu; Yoon-Tae Kang; Yong-Seok Lee; Jeong-Suk Kim; Young-Ho Cho; Byung-In Moon
Circulating tumor cells (CTCs) play an important role in estimating the presence and the metastatic relapse of tumor. Despite of their importance, isolation of viable CTCs is still struggling, since chemical or mechanical damages are unavoidable when separating less than 1000 of CTCs out of billions of other blood components. Furthermore, the current CTC isolation devices show low productivity, since they are produced after a series of complicated fabrication processes. Here, we present a low-cost and mass-producible fabric filters for the viable CTC isolation and the further molecular assay for profiling cancer-associated markers. The fabric filter, produced by polyester monofilament yarns, can be massively produced at extremely low-cost, by showing productivity of ~22filters/s at ~59filters/USD. By utilizing size-based sorting method, the fabric filter is capable to isolate both epithelial and mesenchymal CTCs, while slots with curved walls are beneficial for preventing the cell rupture by reducing 21.6% of mechanical stress compared to the conventional straight-walled slots. We applied our filter to 11 human blood samples and found that the number of CTCs was closely related to the expression level of Ki-67, which is highly overexpressed in proliferative tumors. The fabric filter might be an appropriate caner-screening tool in developing countries, where people suffer from insufficient healthcare services.
Oncotarget | 2017
Dong Hoon Suh; Miseon Kim; Jin Young Choi; Jiyoon Bu; Yoon-Tae Kang; Byung Su Kwon; Banghyun Lee; Kidong Kim; Jae Hong No; Yong-Beom Kim; Young-Ho Cho
The aim of this study was to evaluate circulating tumor cell (CTC) detection in the differential diagnosis of adnexal masses. A total of 87 preoperative women with an indeterminate adnexal mass were prospectively enrolled. Preoperative diagnostic modalities including CTC detection, risk of ovarian malignancy algorithm, risk of malignancy index, and computed tomography or magnetic resonance imaging were compared. Forty-three (49.4%) benign tumors, 13 (14.9%) borderline malignant masses, and 31 (35.7%) cancers were pathologically confirmed. Forty-nine (56.3%) cases were positive for CTCs: 19/43 (44.2%) benign, 10/10 (100%) early-stage, and 14/21 (66.7%) advanced-stage cancer. CTC detection had sensitivities of 77.4%, 100%, and 100% for benign vs. all stage cancer (n = 74), benign vs. stage I–II cancer (n = 53), and benign vs. stage I cancer (n = 49), respectively. CTC detection had a specificity of 55.8% across all comparisons. The sensitivities of the other modalities assayed were decreased in stage I–II cancer and stage I cancer vs. benign masses. Receiver operating characteristic curves showed that CTCs, of which the area under the curve was modest in all stage cancer (0.655), had the widest area under the curve among the evaluated modalities in stage I–II cancer and stage I cancer (0.768 for both). In conclusion, our study findings suggest that preoperative CTCs could have a substantial role in differentiating early stage cancer from benign tumors for adnexal masses.
Lab on a Chip | 2016
Jiyoon Bu; Yoon-Tae Kang; Young-Jun Kim; Young-Ho Cho; Hee Jin Chang; Hojoong Kim; Byung-In Moon; Ho Gak Kim
Nanoscale | 2017
Yoon-Tae Kang; Young-Jun Kim; Jiyoon Bu; Young-Ho Cho; Sae-Won Han; Byung-In Moon
Biomaterials | 2017
Jiyoon Bu; Young-Jun Kim; Yoon-Tae Kang; Tae Hee Lee; Jeong-Suk Kim; Young-Ho Cho; Sae-Won Han
Journal of Micromechanics and Microengineering | 2017
Yoonji Kim; Jiyoon Bu; Young-Ho Cho; Il Tae Son; Sung-Bum Kang
Sensors and Actuators B-chemical | 2018
Yoon-Tae Kang; Young-Jun Kim; Jiyoon Bu; Shilin Chen; Young-Ho Cho; Hyun Min Lee; Chun Jeih Ryu; Yoojoo Lim; Sae-Won Han
Journal of Micromechanics and Microengineering | 2017
Tae Hee Lee; Jiyoon Bu; Jung Eun Moon; Young Jun Kim; Yoon-Tae Kang; Young-Ho Cho; In Sik Kim
Archive | 2015
Young-Ho Cho; Jong-Uk Bu; Jiyoon Bu
international conference on micro electro mechanical systems | 2017
Jiyoon Bu; Young-Jun Kim; Yoon-Tae Kang; Tae Hee Lee; Jeong-Suk Kim; HyeonJun Kim; Young-Ho Cho